 | | Vol. 23.06 – 28 February, 2022 |
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| Researchers showed that viral delivery of GDNF to the striatum, in conjunction with homotopic transplantation of human pluripotent stem cell-derived midbrain dopamine (mDA) neurons, recapitulated brain-wide mDA target innervation.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that functional CAR T cells could be generated within 24 hours from T cells derived from peripheral blood without the need for T cell activation or ex vivo expansion
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[Nature Biomedical Engineering] |
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| In CARTITUDE-1, 5% of patients with multiple myeloma reported movement and neurocognitive treatment-emergent adverse events with ciltacabtagene autoleucel, a B cell maturation antigen-targeted CAR T cell therapy.
[Blood Cancer Journal] |
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| Researchers studied the influence of anthropometric and body composition measurements on CAR-T-related immunotoxicity in 64 patients receiving CD19-directed CAR-T for relapsed/refractory B cell malignancies.
[Haematologica] |
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| The authors evaluated the prevalence of key vascular complications and graft-versus-host disease among 122 pediatric patients with an allogeneic hematopoietic stem cell transplantation between 2001 and 2013.
[Bone Marrow Transplantation] |
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| Scientists proposed adoptive transfer of SARS-CoV-2-specific T cells made resistant to a common immunosuppressant, Tacrolimus, for optimized performance in the immunosuppressed patient.
[Molecular Therapy-Methods & Clinical Development] |
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| To improve CAR-T therapy for glioblastoma, a new TanCAR, comprising the tandem arrangement of IL13 and EphA2 scFv, was generated and validated in vitro and in vivo.
[Molecular Therapy-Oncolytics] |
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| The authors reported a new strategy of blocking the CD7 antigen on the T cell surface with a recombinant anti-CD7 antibody to obtain a sufficient amount of CD7-targeting CAR-T cells for T cell acute lymphoblastic leukemia treatment.
[Molecular Therapy-Oncolytics] |
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| In patients achieving a complete response transcriptomic profiles of bone marrow prior to lymphodepletion showed genes mainly involved in T cell activation.
[Scientific Reports] |
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| The macroscopic view and histological sections revealed that the articular cartilage in the normal saline group was damaged, inflamed, uneven and thin, and had hyperchromatic cell infiltration.
[Scientific Reports] |
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| By harnessing the chemokine system and taking into consideration the chemokine expression profile in the tumor microenvironment, CAR-T cells may be homed into tumors to facilitate direct tumor cell cytolysis.
[Cell Reports Medicine] |
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| Scientists discuss recent studies and emerging research aimed to extend CAR-based therapies beyond oncology in areas such as cardiometabolic disorders, autoimmunity, fibrosis and senescence.
[Nature Metabolism] |
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| Fluidigm Corporation announced a collaboration agreement with the Abu Dhabi Stem Cells Center for development of targeted stem cell therapies and research applications utilizing two Fluidigm® mass cytometry and tissue imaging technologies.
[Fluidigm Corporation] |
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| The FDA granted orphan drug designation to CYNK-101, an investigational natural killer cell-based therapy for treatment of advanced HER2/neu-positive gastric or gastroesophageal junction adenocarcinoma.
[Healio] |
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| The Wisconsin Partnership Program at the University of Wisconsin School of Medicine and Public Health announced four new awards totaling $600,000 to the school’s faculty through its New Investigator Program.
[University of Wisconsin School of Medicine and Public Health] |
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| City of Hope’s Department of Stem Cell Biology and Regenerative Medicine has received a $4.9 million grant to train the next generation of scientific leaders in basic stem cell research and its translation into novel, lifesaving treatments.
[City of Hope] |
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| March 19 – 23, 2022
Prague, Czech Republic & Online |
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| | BioNTech – Gaithersburg, Maryland, United States |
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| | Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland |
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| | Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore |
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| | Babraham Institute – Babraham, England, United Kingdom |
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| TU Dresden – Dresden, Germany |
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