Cell Therapy News Volume 23.07 | Mar 07 2022

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    2022-03-07 | CTN 23.07


    Cell Therapy News by STEMCELL Technologies
    Vol. 23.07 – 7 March, 2022
    TOP STORY

    Human Biliary Epithelial Cells from Discarded Donor Livers Rescue Bile Duct Structure and Function in a Mouse Model of Biliary Disease

    The authors purified human biliary epithelial cells from human livers that were not used for liver transplantation.
    [Cell Stem Cell]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Rabies Virus Glycoprotein-Mediated Transportation and T Cell Infiltration to Brain Tumor by Magnetoelectric Gold Yarnballs

    A rabies virus glycoprotein (RVG)-camouflaged gold yarnball that could boost the targeting efficiency at a brain tumor via dual hierarchy- and RVG-mediated spinal cord transportation, facilitating the decrease of tumor heterogeneity for T cell infiltration, was developed.
    [ACS Nano]

    Abstract

    Adoptive Transfer of Ex Vivo Expanded Regulatory T Cells Improves Immune Cell Engraftment and Therapy-Refractory Chronic GvHD

    Investigators treated three children suffering from severe, therapy-refractory GvHD with polyclonally expanded regulatory T cells generated from the original stem cell donor.
    [Molecular Therapy]

    AbstractGraphical Abstract

    Development of a Scalable Method to Isolate Subsets of Stem Cell-Derived Pancreatic Islet Cells

    Scientists described the generation of an array of monoclonal antibodies against cell surface markers that selectively label stem cell-derived islet cells.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Safety and Efficacy of Autologous, Adipose-Derived Mesenchymal Stem Cells in Patients with Rheumatoid Arthritis: A Phase I/IIa, Open-Label, Non-randomized Pilot Trial

    The authors performed a phase I/IIa non-randomized, open-label study to evaluate safety and efficacy of a single, intravenous infusion of autologous, adipose-derived MSCs over a period of 52 weeks, in patients with active rheumatoid arthritis.
    [Stem Cell Research & Therapy]

    Full Article

    Mesenchymal Stem Cells Protect against Acetaminophen Hepatotoxicity by Secreting Regenerative Cytokine Hepatocyte Growth Factor

    MSCs were comparable to N-acetylcysteine against acetaminophen (APAP)-induced liver failure by secreting hepatocyte growth factor with less regenerative retardation concerns, thus facilitating the application of MSCs in clinical therapy for APAP liver failure.
    [Stem Cell Research & Therapy]

    Full Article

    Effects of Obesity on Reparative Function of Human Adipose Tissue-Derived Mesenchymal Stem Cells on Ischemic Murine Kidneys

    Abdominal adipose tissue-derived mesenchymal stem cell were harvested from patients without or with obesity during kidney donation or bariatric surgery, respectively.
    [International Journal of Obesity]

    Abstract

    Targeted Mesenchymal Stem Cell Therapy Equipped with a Cell-Tissue Nanomatchmaker Attenuates Osteoarthritis Progression

    Investigators developed targeted mesenchymal stem cell therapy for osteoarthritiscartilage using a cell-tissue matchmaking nanoconstruct.
    [Scientific Reports]

    Full Article

    Chimeric Antigen Receptor (CAR) T-cell Treatment for Mantle Cell Lymphoma (MCL)

    Investigators provided an overview for the available management strategies for relapsed mantle cell lymphoma (MCL) and examines the role of CAR T cell in the current and future treatment of MCL.
    [Therapeutic Advances in Hematology]

    Full Article

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    REVIEWS

    Heart Regeneration: 20 Years of Progress and Renewed Optimism

    The field of heart regeneration has entered a renaissance period with remarkable progress in the understanding of endogenous heart regeneration, stem cell differentiation for exogenous cell therapy, and cell-delivery methods.
    [Developmental Cell]

    Abstract

    Harnessing the Chemokine System to Home CAR-T Cells into Solid Tumors

    By harnessing the chemokine system and taking into consideration the chemokine expression profile in the tumor microenvironment, CAR-T cells may be homed into tumors to facilitate direct tumor cell cytolysis.
    [Cell Reports Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    Sinusas Awarded S10 Grant from NIH

    The Yale Translational Research Imaging Center will be upgrading to a novel interventional cardiology ultrasound system, including 2D and 3D transthoracic, transesophageal, and high frequency vascular imaging probes.
    [Yale School of Medicine]

    Press Release

    Celyad Oncology Announces Voluntary Pause of CYAD-101-002 Phase Ib Trial

    Celyad Oncology SA announced it has taken the decision to voluntarily pause the CYAD-101-002 Phase Ib trial due to reports of two fatalities that presented with similar pulmonary findings.
    [Celyad Oncology]

    Press Release

    FEATURED EVENT

    1st International Symposium of Clinical Immunology

    April 2 – April 3, 2022
    Fukuoka, Japan, and Virtual

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    JOB OPPORTUNITIES

    Senior Scientific Officer – Functional Genomics

    Institute of Cancer Research – London, England, United Kingdom

    Research Scientist – CAR T Cells

    BioNTech – Gaithersburg, Maryland, United States

    Research Technician – Placental Development

    Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland

    Postdoctoral Associate – Cell Viability

    Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore

    Research Scientist – T Cell Stimulation

    Babraham Institute – Babraham, England, United Kingdom

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