 | | Vol. 23.08 – 14 March, 2022 |
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| Researchers investigated the role of the intestinal microbiome onvarious outcomes in a multicenter study of patients with B cell lymphoma and leukemia.
[Nature Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Porcine and human stem cell-beta islets made insulin in xenotransplant models, and mouse islets tested in a marginal mass syngeneic transplant model cured diabetes in 92% of recipients within 24–48 hours after transplant.
[Nature Medicine] |
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| Scientists developed a dead-guide RNA-based CRISPR activation screen in primary CD8+ T cells and identified gain-of-function targets for CAR-T engineering.
[Cell Metabolism] |
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| The authors reported that induced pluripotent stem cellss reprogramed from CD62L+ naive and memory T cells followed by CD19-CAR engineering and 3D-organoid system differentiation conferred products with conventional CD8αβ-positive CAR T cell characteristics.
[Cell Stem Cell] |
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| Investigators extracted and identified primary MSCs and verified the promoting effects of tumor-associated mesenchymal stem cells on colorectal cancer (CRC) proliferation and metastasis in vivo and in vitro.
[Molecular Therapy] |
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| Scientists found that curcumin primed adipose tissue-derived mesenchymal stem cell-derived small extracellular vesicles (ADMSCs-sEVs) exhibited an enhanced protective effect compared with free curcumin and ADMSCs-sEV in TBHP-induced chondrocytes.
[Journal of Nanobiotechnology] |
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| Researchers studied the functions of umbilical cord mesenchymal stem cells-released Evs and their implicated molecules in mesangial proliferative glomerulonephritis.
[Cell Communication and Signaling] |
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| Clinical hepatocyte transplantation (HT) is only performed without general anesthesia, while inhalation anesthetics are usually used in animal experiments. The authors suggest that isoflurane may be a possible reason for the discrepancy between the results of animal experiments and the clinical outcomes of HTx.
[Scientific Reports] |
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| Stem cells from rat kidney were separated, and the surface stem cell markers were determined by flow cytometry analysis.
[Environmental Science and Pollution Research] |
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| Scientists discuss the pertinent cardiovascular risks of the growing field of CAR-T cell therapy for today’s cardiologists, including incidence, characteristics, and treatment options, and conclude with an integrated management algorithm.
[European Heart Journal] |
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| The authors provided a comprehensive assessment of the short and long-term safety of hematopoietic stem and progenitor cells-gene therapy from trials using different vector platforms.
[Nature Communications] |
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| Cellevolve Bio and Seattle Children’s Therapeutics announced a collaboration aimed at developing and commercializing a suite of novel multiplex chimeric antigen receptors for the treatment of pediatric CNS malignancies.
[Cellevolve Bio (Business Wire, Inc.)] |
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| Abeona Therapeutics, Inc. announced that target enrollment has been achieved in its pivotal Phase III VIITAL™ study. The objective of VIITAL™ is to evaluate the safety and effectiveness of Abeona’s investigational EB-101 product for the treatment of recessive dystrophic epidermolysis bullosa (RDEB).
[Abeona Therapeutics Inc.] |
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| April 6 – 9, 2022
Heidelberg, Germany |
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| | Aspect Biosystems – Vancouver, British Columbia, Canada |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | BioNTech – Gaithersburg, Maryland, United States |
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| | Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland |
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| | Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore |
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