Cell Therapy News Volume 23.10 | Mar 28 2022

May 12, 2022

114

2022-03-28 | CTN 23.10

Cell Therapy News by STEMCELL Technologies

Vol. 23.10 – 28 March, 2022

TOP STORY

Bioinstructive Implantable Scaffolds for Rapid In Vivo Manufacture and Release of CAR-T Cells

The authors described an implantable Multifunctional Alginate Scaffold for T Cell Engineering and Release that streamlined in vivo CAR-T cell manufacturing and reduced processing time to a single day.
[Nature Biotechnology]

Abstract Press Release

Animal Origin-Free cGMP HSPC Expansion Media

PUBLICATIONSRanked by the impact factor of the journal

GLA/DRST Real-World Outcome Analysis of CAR-T Cell Therapies for Large B Cell Lymphoma in Germany

Investigators reported the first German real-world data on standard-of-care CAR-T cell therapies with the aim to explore risk factors associated with outcome.
[Blood]

Abstract

ATP7B Gene Therapy of Autologous Reprogrammed Hepatocytes Alleviates Copper Accumulation in a Murine Model of Wilson’s Disease

Scientists evaluated the function and efficacy of autologous reprogrammed, ATP7B gene-restored hepatocytes using a murine model of Wilson’s disease.
[Hepatology]

Abstract

Development of Off-the-Shelf Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cells for COVID-19 Therapeutic Intervention

Investigators produced allogeneic hematopoietic stem cell (HSC)-engineered Invariant natural killer T (iNKT) cells through TCR engineering of human cord blood CD34⁺ HSCs and differentiation of these HSCs into iNKT cells in an ex vivo HSC-Derived iNKT Cell Culture.
[Stem Cell Research & Therapy]

Full Article

Characterizing Piggybat- a Transposase for Genetic Modification of T Cells

Researchers utilized the previously described transposase from the little brown bat, designated piggyBat, for production of CD19 specific CAR T cells.
[Molecular Therapy-Methods & Clinical Development]

Abstract Full Article Graphical Abstract

Strategy of Stem Cell Transplantation for Bone Regeneration with Functionalized Biomaterials and Vascularized Tissues in Immunocompetent Mice

Scientists covalently modified alginate with RGD and QK peptides that were injected subcutaneously into immunocompetent mice.
[ACS Biomaterials Science & Engineering]

Abstract Graphical Abstract

A Novel and Efficient CD22 CAR-T Therapy Induced a Robust Antitumor Effect in Relapsed/Refractory Leukemia Patients When Combined with CD19 CAR-T Treatment as a Sequential Therapy

Preclinical investigation of the CD22 CAR-T therapy against B cell malignancies was evaluated by co-culturing CD22 CAR-T cells with tumor cell lines or primary blasts from patients in vitro and using a xenograft mouse model in vivo.
[Experimental Hematology & Oncology]

Full Article

Lack of Tumorigenesis and Protumorigenic Activity of Human Umbilical Cord Mesenchymal Stem Cells in NOD SCID Mice

Researchers observed tumor formation in NOD SCID mice after a single subcutaneous injection of human umbilical cord-mesenchymal stem cells and the effect of these cells on tumor growth in tumor-bearing mice.
[BMC Cancer]

Full Article

Durable Remission for Four Pediatric Patients with High-Risk Relapsed Classical Hodgkin Lymphoma Treated with Brentuximab Vedotin plus Gemcitabine but without Autologous Stem Cell Transplantation: A Report from the Children’s Oncology Group

While the majority of patients with complete responses to the brentuximab vedotin with gemcitabine regimen ultimately underwent high-dose chemotherapy and autologous stem cell transplantation consolidation, four subjects achieved durable complete remissions.
[Pediatric Blood & Cancer]

Abstract

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REVIEWS

Human Placenta-Derived Amniotic Epithelial Cells as a New Therapeutic Hope for COVID-19-Associated Acute Respiratory Distress Syndrome (ARDS) and Systemic Inflammation

Investigators focus on the proposed early and late therapeutic mechanisms of human amniotic epithelial cells and their exosomes to the injured organs.
[Stem Cell Research & Therapy]

Full Article Graphical Abstract

Mesenchymal Stromal Cells for Enhancing Hematopoietic Engraftment and Treatment of Graft-Versus-Host Disease, Hemorrhages and Acute Respiratory Distress Syndrome

The authors summarize current evidence from in vitro studies, animal models, and their clinical experience, to support stromal cell therapy in multiple clinical indications.
[Frontiers in Immunology]

Full Article

CAR-T Cell Therapy for Lung Cancer: Potential and Perspective

Scientists outline the basic structure and generation characteristic of CAR-T cells and summarize the common tumor-associated antigens in clinical trials of CAR-T cell therapy for lung cancer.
[Thoracic Cancer]

Full Article

INDUSTRY AND POLICY NEWS

As Creator of ‘CRISPR Babies’ Nears Release from Prison, Where Does Embryo Editing Stand?

Biophysicist He Jiankui, having served a three-year sentence for creating the world’s first genetically engineered babies, may be released from a Chinese prison this week.
[ScienceInsider]

Press Release

IMAC Holdings, Inc. Announces Initiation of Third and Final Cohort of its Phase I Clinical Study of Umbilical Cord-Derived Mesenchymal Stem Cells for the Treatment of Bradykinesia Due to Parkinson’s Disease

IMAC Holdings, Inc. announced it has initiated the third and final cohort of its Phase I clinical trial for its investigational compound utilizing umbilical cord-derived allogenic mesenchymal stem cells for the treatment of bradykinesia due to Parkinson’s disease.
[IMAC Holdings, Inc.]

Press Release

FEATURED EVENT

Bioinstructive Implantable Scaffolds for Rapid In Vivo Manufacture and Release of CAR-T Cells

GLA/DRST Real-World Outcome Analysis of CAR-T Cell Therapies for Large B Cell Lymphoma in Germany

ATP7B Gene Therapy of Autologous Reprogrammed Hepatocytes Alleviates Copper Accumulation in a Murine Model of Wilson’s Disease

Development of Off-the-Shelf Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cells for COVID-19 Therapeutic Intervention

Characterizing Piggybat- a Transposase for Genetic Modification of T Cells

Strategy of Stem Cell Transplantation for Bone Regeneration with Functionalized Biomaterials and Vascularized Tissues in Immunocompetent Mice

A Novel and Efficient CD22 CAR-T Therapy Induced a Robust Antitumor Effect in Relapsed/Refractory Leukemia Patients When Combined with CD19 CAR-T Treatment as a Sequential Therapy

Lack of Tumorigenesis and Protumorigenic Activity of Human Umbilical Cord Mesenchymal Stem Cells in NOD SCID Mice

Durable Remission for Four Pediatric Patients with High-Risk Relapsed Classical Hodgkin Lymphoma Treated with Brentuximab Vedotin plus Gemcitabine but without Autologous Stem Cell Transplantation: A Report from the Children’s Oncology Group

Human Placenta-Derived Amniotic Epithelial Cells as a New Therapeutic Hope for COVID-19-Associated Acute Respiratory Distress Syndrome (ARDS) and Systemic Inflammation

Mesenchymal Stromal Cells for Enhancing Hematopoietic Engraftment and Treatment of Graft-Versus-Host Disease, Hemorrhages and Acute Respiratory Distress Syndrome

CAR-T Cell Therapy for Lung Cancer: Potential and Perspective

As Creator of ‘CRISPR Babies’ Nears Release from Prison, Where Does Embryo Editing Stand?

IMAC Holdings, Inc. Announces Initiation of Third and Final Cohort of its Phase I Clinical Study of Umbilical Cord-Derived Mesenchymal Stem Cells for the Treatment of Bradykinesia Due to Parkinson’s Disease

13^th Online Dutch Stem Cell Meeting

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Postdoctoral Fellow Position – Translational Research

Science Writer – Blood Cancer

Postdoctoral Fellow – CAR-T Cell Exhaustion in Solid Tumors

Research Engineer – Bioprinted Tissue Therapeutics

Postdoctoral Fellow – Functional Genomics of Lung Cancer

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