 | | Vol. 23.25 – 18 July, 2022 |
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| Transplantation of stem cell-derived β cells with ZnT8 loss of function into mice with pre-existing diabetes significantly improved glycemia restoration and glucose tolerance.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors demonstrated that Sema3F-transduced HSCs stimulate oligodendrocyte progenitor cell (OPC) migration in a neuropilin 2-dependent fashion, which was conserved in middle-aged OPCs.
[EMBO Molecular Medicine] |
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| Scientists used a transcription factor EB nuclear translocation-mediated mesenchymal stem cells co-culture approach to reconstitute autophagy and lysosomal biogenesis, and reduced spinocerebellar ataxia type 3-like behaviors in induced pluripotent stem cells-derived neuron cells models.
[Cell Death & Disease] |
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| Activated CD8+ T cells and interferon-γ were found to stimulate adipogenesis of bone marrow-mesenchymal stromal cells either in vitro or in vivo of aplastic anemia mouse model.
[Cell Death & Disease] |
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| A nude mouse model of subcutaneous xenograft tumor was constructed to detect the effect of miR-139-5p in bone marrow mesenchymal stem cells-derived extracellular vesicles on the tumorigenesis and lung metastasis of bladder cancer cells in vivo.
[Cell Death & Disease] |
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| Investigators compared graft versus host disease (GVHD) and immune reconstitution after myeloablative matched unrelated peripheral blood stem cell allogeneic stem cell transplant between 30 mg/Kg and 60 mg/Kg anti-lymphocyte globulin.
[Bone Marrow Transplantation] |
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| The authors explored the impact of post-transplantation cyclophosphamide (PTCy) on human CD8+ T-cell survival and reconstitution, including what cellular pathways drive PTCy resistance.
[Blood Advances] |
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| Researchers established an immunodeficient murine model of mucopolysaccharidosis type II, which are transplantable human cells, and demonstrated the application of those mice in evaluating the therapeutic efficacy of gene-modified hCD34+ cells.
[Gene Therapy] |
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| Investigators explored the specificity and safety profile of a new T cell receptor (TCR) mimic-based T cell therapy for hepatocellular carcinoma, a solid tumor for which no effective treatment exists.
[Scientific Reports] |
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| Scientists assessed the effects of mesenchymal stem cell treatments using a murine model of chronic ovalbumin-challenged asthma.
[Scientific Reports] |
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| The authors summarize the current understanding of bone remodeling and future research directions with the aim of providing a clinically relevant biological background with which to identify targets for therapeutic strategies in osteoporosis.
[Bone Research] |
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| To address the unmet need for treatment modalities with increased effectiveness, immune-based therapies such as immune-checkpoint blockade, human papilloma virus-directed vaccines and adoptive T cell therapies have emerged as potential treatment options for advanced penile cancer.
[Nature Reviews Urology] |
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| Scientists outline the basic structure and characteristics of CAR-T cells among different period, and summarize the common tumor-associated antigens in clinical trials of CAR-T cell therapy for thoracic malignancies.
[Frontiers in Immunology] |
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| Dr. Nathan Singh has received a Damon Runyon Clinical Investigator Award for his research on understanding why CAR-T cell therapy is effective in some patients but not others.
[Washington University School of Medicine] |
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| October 3 – 5, 2022
Vancouver, British Columbia, Canada |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Lehigh University – Bethlehem, Pennsylvania, Untied States |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | University Medical Center Utrecht – Utrecht, Netherlands |
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