 | | Vol. 23.28 – 15 August, 2022 |
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| Investigators developed a straightforward strategy in which dendritic cells (DCs) served as a cell reactor to exocytose high-efficient DC-derived small extracellular vesicles-mimicking aggregation-induced emission nanoparticles at a scaled-up yield for synergistic photodynamic immunotherapy.
[ACS Nano] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists established a CRISPRa mouse (dCas9a-SAMKI) for inducing gene expression in vivo and in vitro. Using dCas9a-SAMKI primary lymphocytes, they induced B cell restricted genes in T cells and vice versa, demonstrating the power of this system.
[Nature Communications] |
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| The authors developed a new generation of collagen-binding extracellular vesicles (EVs) which were designed to bind to collagen in the extracellular matrix (ECM) and form an EV-ECM complex to improve EVs’ in situ retention and therapeutic efficacy after transplantation.
[Theranostics] |
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| Investigators applied their recently developed digital-PCR assays to monitor CD19-CAR-T cell kinetics in cerebrospinal fluid and blood in real-world patients with neurotoxicity.
[Haematologica] |
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| Researchers established a potential therapeutic strategy for motor neuron diseases by in vivo directional differentiation of human-induced pluripotent stem cells engineered with motor neuron specific transcription factors and Tet-On system.
[Cell Proliferation] |
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| The authors isolated c-kit+VEGFR-2+ cells from rat bone marrow-derived mesenchymal stem cells (MSCs), and assessed potential of c-kit+VEGFR-2+ MSCs to differentiate towards cardiovascular cells and their efficiency of repairing the infarcted myocardium after transplantation.
[Stem Cell Reviews and Reports] |
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| Blood-derived angiogenic cells or mesenchymal stem cells were injected intramuscularly following the ligation of the iliac artery in a murine model. Their ability to enhance revascularization, impair necrosis, and modulate inflammatory processes in the affected limb was investigated.
[Stem Cell Research & Therapy] |
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| Scientists established a novel non-invasive in vivo imaging system to visualize the activity of neural grafts by which they could simultaneously demonstrate the circuit-level integration between the graft and host and the contribution of graft neuronal activity to host behavior.
[Communications Biology] |
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| The efficaciousness of prostate specific membrane antigen-CAR-T was evaluated in vitro using ELISA and RTCA. The effect of intermixed therapy was assessed in vivo utilizing a human prostate cancer liver metastasis mouse model and a human prostate cancer cell xenograft mouse model.
[Journal of Cancer Research and Clinical Oncology] |
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| To develop reliable scaffold-free periodontal tissue regenerative cell therapy by clumps of mesenchymal stem cell/extracellular matrix complexes (C-MSCs), the authors investigated the periodontal tissue regenerative capacity of C-MSCs and the behavior of the transplanted cells.
[Journal of Tissue Engineering and Regenerative Medicine] |
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| Researchers demonstrated a new method for establishing a rabbit model of growth plate injury, which provided a simple and rapid modeling process, good modeling effect, high modeling accuracy, and convenient scaffold implantation.
[Tissue Engineering Part C-Methods] |
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| Investigators discuss how the design of a vertical nanoprobe biointerface determines its ability to interrogate and control a cell.
[Nature Reviews Materials] |
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| Scientists provide an update on recent clinical applications using either human pluripotent stem cells or mesenchymal stem cells derived from bone marrow, adipose tissue, or the umbilical cord for the treatment of human diseases.
[Signal Transduction and Targeted Therapy] |
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| The authors discuss the development, as well as mechanism of CRISPR/Cas9 and its applications and challenges in gene therapy for eye diseases.
[Eye] |
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| RoslinCT, a cell and gene therapy Contract Development and Manufacturing Organisation (‘CDMO’), and Lykan Bioscience, an innovative CDMO focused on cell-based therapies, announced that they have entered into a business combination agreement to form a global leading innovative advanced therapies CDMO.
[RoslinCT] |
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| While AstraZeneca may be a major player in the oncology space, the company has been noticeably absent as the first wave of CAR-T therapies hit the market over the past five years. But movement is happening behind the scenes.
[Fierce Biotech] |
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| University of Florida (UF) brain cancer researcher Dr. Lan Hoang-Minh has been awarded a $100,000 grant from the St. Baldrick’s Foundation for a preclinical research project seeking to advance adoptive T cell therapy for pediatric brain tumors.
[University of Florida Health] |
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| September 27 – 29, 2022
Leuven, Belgium |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Illinois at Chicago – Chicago, Illinois, United States |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | Human Technopole – Milano, Italy |
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