 | | Vol. 23.29 – 22 August, 2022 |
| |
|
|
| In a rat primary liver cancer model, the authors showed that mesenchymal stem cells (MSCs) with high SIRT1 expression promoted macrophage recruitment and synergistically facilitated liver cancer occurrence by secreting CCL5.
[Hepatology] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators showed that harnessing invariant natural killer T (iNKT) cells with a second T cell receptor (TCR) specific for a tumor-associated peptide generated bispecific effectors for CD1d- and major histocompatibility complex–restricted antigens in vitro.
[Science Immunology] |
|
|
|
| Scientists identified Ly6C+/CD11b+ inflammatory monocytes as the primary source of IFNβ and found that active type-I-IFN signaling in tumor-infiltrating inflammatory monocytes was associated with T cell expansion in patients treated with immune checkpoint blockade.
[Nature Communications] |
|
|
|
| Researchers developed a mesenchymal stromal cell-based co-culture system to optimize transplantation outcome of CRISPR-Cas9 gene-edited human hematopoietic stem and progenitor cells (HSPCs).
[Molecular Therapy] |
|
|
|
| The authors engineered a cytokine-anchored CAR T cell system using a chimeric IL-5-CD28-CD3ζ receptor to trigger T cell-mediated killing of eosinophils that were elevated during severe asthma attacks.
[Cell Discovery] |
|
|
|
| Scientists identified a critical and synergistic role of rehabilitation and neural stem cell therapy in driving neural plasticity to support functional recovery after chronic and severe spinal cord injury.
[JCI Insight] |
|
|
|
| Investigators designed a unique therapeutic to prevent and reverse relapses due to lost or reduced CD19 expression. This novel biologic, a CAR T Engager, bound CD20 and displayed the CD19 extracellular domain.
[Oncoimmunology] |
|
|
|
| The authors developed a dual stem cell approach for effective vascular regeneration that continuously secreted stromal-derived factor-1α to simultaneously promote natal vasculogenesis and angiogenesis.
[Experimental & Molecular Medicine] |
|
|
|
| Following administration of a preparative regimen, researchers infused donor lymphocytes, followed by cyclophosphamide to induce bidirectional tolerance, then infusion of CD34-selected cells.
[Bone Marrow Transplantation] |
|
|
|
| Scientists conducted a matched-pair analysis of post-transplant cyclophosphamide-haplo and umbilical cord blood transplantation using the Japanese registry data.
[Bone Marrow Transplantation] |
|
|
|
| The authors investigated pulmonary function following hematopoietic stem cell transplantation in terms of its change and the clinical significance of its decline.
[Scientific Reports] |
|
|
|
|
| Given the continuous recruitment of myelomonocytic cells into tumor tissues, macrophages are candidates for cell therapy with the development of CAR effector cells.
[Nature Reviews Drug Discovery] |
|
|
|
| Novel approaches for metabolically “preconditioning” stem cells prior to transplant harness metabolic machinery to optimize stem cell survival upon transplant.
[Neurobiology of Disease] |
|
|
|
| Scientists study the benefits and disadvantages of stem cell therapy, especially for patients who have dementia.
[Brain and Behavior] |
|
|
|
|
| Biomedical scientists using embryonic stem cells or fetal tissue could find their studies at risk in conservative states aiming to redefine personhood after the US Supreme Court’s rollback of abortion rights.
[Bloomberg Law] |
|
|
|
| Innovative Cellular Therapeutics, Inc. announced that the first patient has been enrolled in its Phase I trial of GCC19CART for relapsed/refractory metastatic colorectal cancer.
[Innovative Cellular Therapeutics, Inc.] |
|
|
|
|
| November 10 – 12, 2022
Bordeaux, France |
|
|
|
|
|
| | Darmstadt University of Technology – Darmstadt, Germany |
|
|
|
| | The University of Chicago – Chicago, Illinois, United States |
|
|
|
| | Shenzhen Institute of Advanced Technology – Shenzhen, China |
|
|
|
| | National Research Council Canada – Toronto, Ontario, Canada |
|
|
|
| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
