 | | Vol. 23.33 – 26 September, 2022 |
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Researchers performed single-cell transcriptome sequencing of 105 pretreatment and post-treatment peripheral blood mononuclear cell samples, and infusion products collected from 32 individuals with large B cell lymphoma treated with CD19 CAR-T products.
[Nature Medicine] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists developed healthy donor-derived, CD7-targeting CAR-T cells with genetic modifications to resist fratricide, graft-versus-host disease and allogeneic rejection, as well as to potentiate antitumor function.
[Cell Research] |
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| Investigators developed CAR T cells directed against one of the targets, FOLR1, and demonstrated their pre-clinical efficacy against CBFA2T3-GLIS2 acute megakaryoblastic leukemia using in vitro and xenograft models.
[Journal of Clinical Investigation] |
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| Researchers evaluated the potential of Tan IIA drug-loaded nanoparticles to improve iPSC-derived neural stem cells engraftment and efficacy, thus potentially leading to enhanced cellular, tissue, and functional recovery in a translational pig ischemic stroke model.
[Stem Cells Translational Medicine] |
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| The authors developed a single-cell 3D spatial correlation method to track transplanted MSCs based on deep tissue microscopy of fluorescent nanoparticles and immunofluorescence of key proteins.
[Stem Cell Reports] |
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| Investigators demonstrated that co-transplantation of hypoxia-preconditioned human umbilical cord MSC with ovarian tissue improved earlier vascularization of ovarian grafts in the early post-grafting period.
[Stem Cell Research & Therapy] |
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| In 394 patients diagnosed with de novo acute myeloid leukemia who had a normal karyotype, the genetic profiling via targeted deep sequencing of 45 genes revealed 59 patients carrying secondary-type mutations.
[Bone Marrow Transplantation] |
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| Scientists showed a relapsed and refractory thyroid cancer patient treated with thyroid-stimulating hormone receptor + (TSHR) CD19 CAR-T, a combination of two 2nd generation CAR-T molecules targeting both TSHR and CD19.
[Experimental Hematology & Oncology] |
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| 22 patients with lupus nephritis refractory to immunosuppressive therapy were enrolled. 20 patients were examined closely and two cases died within 100 days after autologous hematopoietic cell transplantation.
[Lupus] |
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| Investigators discuss examples from the past decade of the use of patient-derived xenograft models for precision oncology, from translational research to drug discovery.
[Nature Reviews Clinical Oncology] |
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| The authors describe the efforts to manipulate the immune system against cancer and discuss different targets and cell types that can be exploited to promote the antitumor immune response.
[Signal Transduction and Targeted Therapy] |
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| Artiva Biotherapeutics, Inc. announced that the US FDA has cleared the company’s investigational new drug (IND) application for AB-201. AB-201 is an allogeneic HER2-targeted CAR NK cell therapy for the treatment of solid tumors in the outpatient setting with the option for repeat dosing.
[Artiva Biotherapeutics, Inc.] |
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| October 16 – 21, 2022
Ventura, California, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Yale University – New Haven, Connecticut, United States |
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| | UC San Francisco – San Francisco, California, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | USC Children’s Hospital Los Angeles – Los Angeles, California, United States |
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Cancer Stem Cell News
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