Cell Therapy News Volume 23.40 | Nov 21 2022

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    2022-11-21 | CTN 23.40


    Cell Therapy News by STEMCELL Technologies
    Vol. 23.40 – 21 November, 2022
    TOP STORY

    Elevated CD47 Is a Hallmark of Dysfunctional Aged Muscle Stem Cells That Can Be Targeted to Augment Regeneration

    Researchers capitalized on mass cytometry to identify high CD47 expression as a hallmark of dysfunctional muscle stem cells with impaired regenerative capacity that predominate with aging.
    [Cell Stem Cell]

    AbstractGraphical Abstract
    Facts Vs. claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    Transplantable Human Thyroid Organoids Generated from Embryonic Stem Cells to Rescue Hypothyroidism

    The authors reported the generation of transplantable thyroid organoids derived from human embryonic stem cells capable of restoring plasma thyroid hormone in athyreotic mice.
    [Nature Communications]

    Full Article

    The IAP Antagonist Birinapant Enhances Chimeric Antigen Receptor T Cell Therapy for Glioblastoma by Overcoming Antigen Heterogeneity

    Investigators developed an approach that combines CAR-T cells with inhibitor of apoptosis protein (IAP) antagonists, a new class of small molecules that mediate the degradation of IAPs, to treat glioblastoma multiforme.
    [Molecular Therapy Oncolytics]

    AbstractFull ArticleGraphical Abstract

    Combined Targeting of Soluble Latent TGF-ß and a Solid Tumor-Associated Antigen with Adapter CAR T Cells

    Researchers showed that adapter CAR T cells in combination with the respective adapter can be used to sense soluble tumor-derived latent TGF-β, both in vitro and in vivo.
    [OncoImmunology]

    Full Article

    Therapeutic Effects of Anti-PD1 Immunotherapy on Hepatocellular Carcinoma under Administration of Tacrolimus

    Investigators used a murine allogeneic skin transplantation model and murine syngeneic subcutaneous and orthotopic hepatocellular carcinoma models and measured the tumor volume and the change in tumor-infiltrating lymphocytes.
    [Transplantation]

    Full Article

    Intravenous Mesenchymal Stem Cell Administration Modulates Monocytes/Macrophages and Ameliorates Asthmatic Airway Inflammation in a Murine Asthma Model

    Scientists determined the effect of human umbilical cord-derived mesenchymal stem cells on asthmatic lungs by modulating innate immune cells and effector T cells using a murine asthmatic model.
    [Molecular and Cellular Biology]

    Full ArticleGraphical Abstract

    MRI Tracking of Human Wharton’s Jelly Stem Cells Seeded onto Acellular Dermal Matrix Labeled with Superparamagnetic Iron Oxide Nanoparticles in Burn Wounds

    Researchers investigated tracking of human Wharton’s jelly stem cells seeded onto an acellular dermal matrix and labeled with superparamagnetic iron oxide nanoparticles by magnetic resonance imaging (MRI) in burn injury.
    [Burns & Trauma]

    Full Article

    Placental Pathology Associated with Lenticulostriate Vasculopathy (LSV) in Preterm Infants

    The authors examined the frequency and type of placental abnormalities in neonates with LSV. They found that there were no significant differences for any type of placental abnormities between LSV and control groups.
    [Journal of Perinatology]

    Abstract
    Who does immunology research in the Bolivian Andes? He does. Read Jason Young's story.
    REVIEWS

    Cell-Based Therapies for Neurological Disorders — the Bioreactor Hypothesis

    Investigators synthesize results from over 20 years of animal studies that illustrate how transdifferentiation, cell replacement, and restoration of damaged tissues in the central nervous system are highly unlikely mechanisms.
    [Nature Reviews Neurology]

    Abstract

    Engineered T Cell Therapy for Viral and Non-Viral Epithelial Cancers

    The authors review and consolidate understanding gained from clinical trials to treat viral and non-viral epithelial cancers with cell and gene therapy and examine how past experience may guide future strategy in treatment and biomarker discovery.
    [Cancer Cell]

    Abstract

    Editing a Gateway for Cell Therapy across the Blood–Brain Barrier

    Scientists describe experimental approaches that have been developed in which cells are either engineered to express cell surface proteins mimicking infiltrating immune cells or cell grafts are preconditioned with hypoxia or incubated with pharmacological agents or cytokines.
    [Brain]

    Abstract
    INDUSTRY AND POLICY NEWS

    Umoja Biopharma and IASO Biotherapeutics Announce Research Collaboration to Bring Off-the-Shelf Therapies to Patients with Hematological Malignancies

    Umoja Biopharma, Inc. and IASO Biotherapeutics announced that they have entered into a research agreement to evaluate Umoja’s iCIL platform with IASO’s best-in-class CARs.
    [Umoja Biopharma, Inc.]

    Press Release
    FEATURED EVENT

    Emerging Cellular Therapies at the Forefront of Cancer Immunotherapy

    January 29 – February 2, 2023
    Banff, Alberta, Canada

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cancer/Stem Cell Biology

    City of Hope – Los Angeles, California, United States

    Postdoctoral Associate – Human Intestinal Biology

    Baylor College of Medicine – Houston, Texas, United States

    PhD Student – Cell-Adhesive Peptides

    Biosynth – Lelystad, Netherlands

    Postdoc Position – Human Progenitor Cells

    University of Bristol – Bristol, England, United Kingdom

    Senior Program Associate – Science in the City

    STEMCELL Technologies, Inc. – Boston, Massachusetts, United States

    > See All Jobs

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