Cell Therapy News Volume 23.41 | Dec 5 2022

    By
    Bob
    -
    0
    25








    2022-12-05 | CTN 23.41


    Cell Therapy News by STEMCELL Technologies
    Vol. 23.41 – 5 December, 2022
    TOP STORY

    Metabolic Changes Associated with Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration

    The authors demonstrated the importance of HMGCS2-induced ketogenesis as a means to regulate metabolic response to cardiomyocyte injury, thus allowing cell dedifferentiation and proliferation as a regenerative response.
    [Circulation]

    Abstract
    World Oncology Cell Therapy Congress 2023
    PUBLICATIONSRanked by the impact factor of the journal

    Generation of Neural Organoids for Spinal-Cord Regeneration via the Direct Reprogramming of Human Astrocytes

    In mice with complete spinal-cord injury, organoids transplanted into the lesion differentiated into spinal-cord neurons, which migrated and formed synapses with host neurons.
    [Nature Biomedical Engineering]

    Abstract

    Mesenchymal Stem/Stromal Cells Primed by Inflammatory Cytokines Alleviate Psoriasis-Like Inflammation via the TSG-6-Neutrophil Axis

    Investigators found that subcutaneous application of umbilical cord-derived MSCs primed by interferon-γ and tumor necrosis factor-α exhibited remarkable therapeutic efficacy on imiquimod-induced psoriasis-like inflammation in mice.
    [Cell Death & Disease]

    Full Article

    Activation Priming and Cytokine Polyfunctionality Modulate the Enhanced Functionality of Low-Affinity CD19 CAR T Cells

    Researchers demonstrated that the enhanced functionality of low-affinity CAT CAR T-cells was a consequence of an antigen-dependent priming.
    [Blood Advances]

    Abstract

    Cord Blood Transplantation for Nonmalignant Disorders: Early Functional Immunity and High Survival

    The authors evaluated the two-year Overall Survival after umbilical cord blood transplantation in patients with non-malignant disorders enrolled on a prospective clinical trial using either 5/6 or 6/6 umbilical cord blood as cell source.
    [Blood Advances]

    Abstract

    Mesenchymal Stem Cells Suppressed Skin and Lung Inflammation and Fibrosis in Topoisomerase I-induced Systemic Sclerosis Associated with Lung Disease Mouse Model

    Researchers investigated the therapeutic effects and mechanisms of treatment of bone marrow-MSC derived from C57BL/6 on the topoisomerase I induced systemic sclerosis associated with lung interstitial lung disease like mice model.
    [Cell and Tissue Research]

    Abstract

    SSTR2 as an Anatomical Imaging Marker and a Safety Switch to Monitor and Manage CAR T Cell Toxicity

    Using intercellular adhesion molecule 1-specific CAR T cells that secrete interleukin-12 as a model, scientists examined the potential of somatostatin receptor 2 (SSTR2) as a safety switch when combined with the SSTR2-specific maytansine-octreotate conjugate PEN-221.
    [Scientific Reports]

    Full Article

    Advantages of the Retroperitoneal Retrocolic Space as the Transplant Site for Encapsulated Xenogeneic Islets

    The authors tested a new polymer combination for islet encapsulation and transplantation and explored a new site for xenogeneic islet transplantation in mice.
    [Xenotransplantation]

    Abstract

    Anti-BCMA/CD19 CAR T Cells with Early Immunomodulatory Maintenance for Multiple Myeloma Responding to Initial or Later-Line Therapy

    Researchers conducted a Phase I clinical trial of anti-BCMA CAR T cells with or without anti-CD19 CAR T cells in multiple myeloma patients responding to third- or later-line therapy or high-risk patients responding to first-line therapy, followed by early lenalidomide or pomalidomide maintenance.
    [Blood Cancer Discovery]

    Abstract
    ON1090CS-Ebook Genome Editing Applications_728x90
    REVIEWS

    Overcoming On-Target, Off-Tumor Toxicity of CAR T Cell Therapy for Solid Tumors

    Scientists summarize current clinical evidence of off-tumor toxicity (OTOT) with CAR T cells in the treatment of solid tumours and discuss the utility of preclinical mouse models in predicting clinical OTOT.
    [Nature Reviews Clinical Oncology]

    Abstract

    The Future of Engineered Immune Cell Therapies

    Investigators discuss current progress in treating human disease with immune cell therapeutics, emerging strategies for immune cell engineering, and challenges facing the field, with a particular emphasis on the treatment of cancer.
    [Science]

    Abstract

    The Emerging Era of Cell Engineering: Harnessing the Modularity of Cells to Program Complex Biological Function

    The authors discuss the emerging era of biological engineering in which living cells are used as building blocks to address therapeutic challenges.
    [Science]

    Abstract
    INDUSTRY AND POLICY NEWS

    Caribou Biosciences Announces the FDA Granted Regenerative Medicine Advanced Therapy (RMAT) and Fast Track Designations to CB-010, an Allogeneic Anti-CD19 CAR-T Cell Therapy

    Caribou Biosciences, Inc. announced that the US FDA has granted CB-010 RMAT designation for relapsed or refractory large B cell lymphoma and Fast Track designation for relapsed or refractory B cell non-Hodgkin lymphoma.
    [Caribou Biosciences, Inc.]

    Press Release

    FDA Approves First Gene Therapy to Treat Adults with Hemophilia B

    The US FDA approved Hemgenix, an adeno-associated virus vector-based gene therapy for the treatment of adults with Hemophilia B who currently use Factor IX prophylaxis therapy, or have a current or historical life-threatening hemorrhage, or have repeated, serious spontaneous bleeding episodes.
    [FDA]

    Press Release
    FEATURED EVENT

    AACR Special Conference: Acute Myeloid Leukemia and Myelodysplastic Syndrome

    January 23 – 25, 2023
    Austin, Texas, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Stem Cells and Regeneration

    University of Bristol – Bristol, England, United Kingdom

    PhD Positions – Biomedical Sciences

    Max Delbrück Center for Molecular Medicine – Berlin-Buch, Germany

    Faculty Position – Cell Therapy and Regenerative Medicine

    Taipei Medical University – Taipei, Taiwan

    Postdoctoral Fellow – Cancer Tumor Microenvironment

    Centre for Oncology and Immunology – Hong Kong, Hong Kong

    Postdoctoral Fellow – Cancer/Stem Cell Biology

    City of Hope – Los Angeles, California, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Cell Therapy News Twitter