 | | Vol. 23.42 – 12 December, 2022 |
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| Researchers developed a genetic platform that combined autonomous antigen-induced production of an accessory molecule with constitutive CAR expression in a single lentiviral vector called Uni-Vect.
[Cancer Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that the proliferation of CD8αβ cytotoxic CAR T cells in solid tumours could be enhanced by deriving and expanding them from a single human induced-pluripotent-stem-cell clone bearing a CAR selected for efficient differentiation.
[Nature Biomedical Engineering] |
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| In vivo, single intrasplenic injection of degrading liver sinusoidal endothelial cells (dLSECs) alleviated advanced liver fibrosis in mice, while intraperitoneal administration of liver-targeting peptide-modified dLSECs showed enhanced fibrosis-targeting effects.
[Advanced Science] |
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| The characteristics of Wharton’s jelly mesenchymal stem cells (MSCs) were systematically analyzed by single cell and spatial transcriptome sequencing. Additionally, the biofunctional-type MSCs selected in this study exhibited promising wound repair properties.
[Advanced Science] |
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| Decellularisation was carried out on bone, liver, and small intestinal tissues and the resultant decellularised materials were biochemically and mechanically characterized.
[Acta Biomaterialia] |
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| Among 40 patients who received anti-CD22 CAR T-cells there were no differences in in vivo expansion, persistence, incidence of toxicities, or disease response between groups with cryopreserved and fresh CAR T-cells.
[Molecular Therapy-Methods & Clinical Development] |
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| In 38 consecutive patients with aggressive lymphoproliferative disease investigators measured a coagulative laboratory panel at baseline and early after infusion of anti-CD19 CAR-T.
[British Journal of Haematology] |
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| The upper part of vibrissa follicles from nestin-driven green-fluorescent protein (GFP) transgenic mice, containing GFP-expressing HAP stem cells, were transplanted in the dorsal area of athymic nude mice.
[Scientific Reports] |
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| Mouse IgG anti-disialoganglioside GD2 antibody-secreting mouse mesenchymal stem cells were developed, and their anti-tumor effects were validated in an in vivo neuroblastoma mouse model.
[Pediatric Surgery International] |
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| Investigators focus on gene transport technologies for engineering MSCs and the application of strategies for selecting optimal delivery genes.
[Bioactive Materials] |
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| Scientists discuss tumor microenvironment-associated aspects with an emphasis on T cell trafficking, extracellular matrix barriers, abnormal vasculature, solid tumor heterogenicity, and immune suppressive microenvironment.
[Clinical and Translational Medicine] |
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| The authors describe the current state of preclinical spheroid research and highlight two key examples of spheroid use in clinically relevant disease modeling.
[npj Regenerative Medicine] |
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| Autolus Therapeutics plc announced that the Phase II pivotal FELIX clinical trial of obecabtagene autoleucel in relapsed/refractory adult acute lymphoblastic leukemia has met its primary endpoint as verified by an independent data monitoring committee.
[Autolus Therapeutics plc] |
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| February 5 – 8, 2023
Keystone, Colorado, United States |
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| | University of California Irvine – Irvine, California, United States |
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| | NYU Langone Medical Center – New York, New York, United States |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | Max Delbrück Center for Molecular Medicine – Berlin-Buch, Germany |
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| | Novartis – East Hanover, New Jersey, United States |
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