 | | Vol. 24.00 – 9 January, 2023 |
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| Scientists developed a bifunctional whole cancer cell–based therapeutic with direct tumor-killing and immunostimulatory roles.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators demonstrated that constructing in vivo osteo-organoids by implanting bone morphogenetic protein–2 (BMP-2)–loaded scaffolds into the internal muscle pocket near the femur of mice supported the growth and subsequent harvest of therapeutically useful cells.
[Science Advances] |
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| The authors reported a multicenter retrospective study assessing the safety, toxicities, and outcomes of allogeneic hematopoietic cell transplantation in large B-cell lymphoma patients following CAR T failure.
[Haematologica] |
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| Using immunolabeling of donor vs. recipient hematopoeitic stem cells (HSCs), researchers demonstrated that HSCs from the host animals colonized the subcutaneously transplanted femurs after transplantation, while the HSCs from the donor disappeared.
[Stem Cell Reviews and Reports] |
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| Nude mice were used to prepare a full-thickness skin defect wound model to detect the repair effect of epidermal stem cells (EpiSCs). The biosafety of EpiSCs was double tested in vitro and in vivo.
[Stem Cell Research & Therapy] |
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| Researchers tested if delayed bone marrow recovery following CAR-T cell therapy was caused by elevation of pro-inflammatory cytokines leading to apoptosis and depletion of hematopoietic stem and progenitor cells.
[Transplantation And Cellular Therapy] |
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| Investigators explored whether c-Jun overexpression could improve the persistence and antitumor efficacy of DAP CAR-T cells.
[Immunotherapy] |
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| Scientists demonstrated that after a short systemic treatment with a specific inhibitor of the small RhoGTPase Cdc42, transplanting aged hematopoietic stem cells from treated mice was sufficient to extend the healthspan and lifespan of aged immunocompromised mice.
[Npj Regenerative Medicine] |
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Researchers tested if hair follicles transplanted into human scars could facilitate tissue regeneration and actively remodel fibrotic tissue, similar to how they remodel healthy skin.
[Npj Regenerative Medicine] |
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| Scientists describe advances in adrenal cell transplants and gene therapy that may allow physiological cortisol production for children and adults with primary adrenal insufficiency.
[Journal Of Clinical Endocrinology & Metabolism] |
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| Investigators summarize the characteristics of the limbal stem cells niche and their current and future roles in restoring corneal homeostasis in eyes with limbal stem cell dysfunction.
[European Journal of Ophthalmology] |
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| The authors summarize the progress in stem-cell-based therapies for corneal diseases along with their history, underlying mechanisms, limitations, and future areas for development.
[Current Opinion In Ophthalmology] |
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| A trial led by City of Hope contributed to the US FDA’s approval of mosunetuzumab, the first bispecific antibody to treat people with relapsed or difficult to treat follicular lymphoma .
[City of Hope] |
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2seventy bio, Inc. announced an amendment to its collaboration with Regeneron that will facilitate an expanded and accelerated development plan for novel cell therapy-based combinations for solid tumors.
[2seventy bio, Inc.] |
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| February 5 – 8, 2023
Keystone, Colorado, United States |
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| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Dankook University – Seoul, South Korea |
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| | Columbia University – New York, New York, United States |
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| | US FDA – Silver Spring, Maryland, United States |
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| | UTHSC-Houston – Houston, Texas, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
