Cell Therapy News Volume 24.02 | Jan 23 2023

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    2023-01-23 | CTN 24.02


    Cell Therapy News by STEMCELL Technologies
    Vol. 24.02 – 23 January, 2023
    TOP STORY

    Allogeneic BCMA-Targeting CAR T Cells in Relapsed/Refractory Multiple Myeloma: Phase I UNIVERSAL Trial Interim Results

    Investigators evaluated escalating doses of ALLO-715 after lymphodepletion with an anti-CD52 antibody-containing regimen in 43 patients with relapsed/refractory multiple myeloma.
    [Nature Medicine]

    AbstractPress Release
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    PUBLICATIONSRanked by the impact factor of the journal

    Precision Targeting of Autoantigen-Specific B Cells in Muscle-Specific Tyrosine Kinase Myasthenia Gravis with Chimeric Autoantibody Receptor T Cells

    Researchers engineered T cells to express a muscle-specific tyrosine kinase (MuSK) chimeric autoantibody receptor with CD137-CD3ζ signaling domains for precision targeting of B cells expressing anti-MuSK autoantibodies.
    [Nature Biotechnology]

    Full ArticlePress Release

    Improvements in Gut Microbiota Dysbiosis in Aged Mice Transplanted with Adipose-Derived Stem Cells

    Scientists used C57BL/6J mice of different ages to carry out the and extracted adipose-derived stem cells from young mice as donors. They further analyzed the species composition of intestinal microorganisms.
    [Stem Cells And Development]

    Abstract

    Transplanted Human iPSC-Derived Vascular Endothelial Cells Promote Functional Recovery by Recruitment of Regulatory T Cells to Ischemic White Matter in the Brain

    The authors investigated contribution of the immune system, especially Tregs, to the mechanism whereby human induced pluripotent stem cell transplantation ameliorated white matter infarct.
    [Journal of Neuroinflammation]

    Full Article

    Safety and Efficacy of Autologous Stem Cell Transplantation in Dialysis-Dependent Myeloma Patients—the DIADEM Study from the Chronic Malignancies Working Party of the EBMT

    Investigators reported on the outcomes of 110 patients, median age 57 years, who had become dialysis-dependent pre-autologous stem cell transplantation (ASCT) and who underwent a first ASCT.
    [Bone Marrow Transplantation]

    Abstract

    Enzyme-Cleaved Bone Marrow Transplantation Improves the Engraftment of Bone Marrow Mesenchymal Stem Cells

    Successful engraftment of bone marrow mesenchymal stem cell (MSC) to the new bone formation occured in collagenase-integrated-bone marrow transplantation (BMT) mice, while routine BMT mice did not recruit bone marrow MSC.
    [JBMR Plus]

    Abstract

    Large-Gap Peripheral Nerve Repair Using Xenogeneic Transplants in Rhesus Macaques

    Researchers reported the repair of fully transected radial nerves in 10 Rhesus Macaques using viable, whole sciatic nerve from genetically engineered, designated pathogen free porcine donors.
    [Xenotransplantation]

    Full Article

    Astrocytes Transplanted during Early Postnatal Development Integrate, Mature, and Survive Long-Term in Mouse Cortex

    To better understand how astrocytes acquire their unique features, scientists transplanted immature mouse cortical astrocytes into the developing cortex of mice and assessed their integration, maturation, and survival.
    [Journal Of Neuroscience]

    Abstract

    Transplantation of Hybrid Adipose-Derived Stem Cell Sheet with Autologous Peritoneum: An In Vivo Feasibility Study

    Researchers explored the feasibility of using the peritoneum as a support for the precise transplantation of adipose-derived stem cell sheets during surgery.
    [Heliyon]

    Full ArticleGraphical Abstract
    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    REVIEWS

    Challenges in the Clinical Advancement of Cell Therapies for Parkinson’s Disease

    Scientists discuss challenges pertaining to cell sources, functional and safety testing, manufacturing, and address clinical-trial design to advance the development of cell therapies for Parkinson’s disease.
    [Nature Biomedical Engineering]

    Abstract

    Application of Nanomaterials in Stem Cell-Based Therapeutics for Cardiac Repair and Regeneration

    Investigators discuss the current status and limitations of stem cells and cell-derived exosomes/micro RNAs based cardiac therapy, and evaluate the advantages and disadvantages of the relevant nanomaterials.
    [Small]

    Abstract

    Chimeric Antigen Receptor (CAR)-Based Therapies beyond Cancer

    The authors review CAR-based adoptive cell transfer therapeutic areas other than oncology such as infection, allergy, autoimmunity, transplantation, and fibrotic repair.
    [European Journal Of Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Tevogen
    Bio Announces Positive Proof-of-Concept Clinical Trial Results of Its Off-the-Shelf, Allogeneic Cytotoxic CD8+ T Cell Therapy for Treatment of Acute High-Risk COVID Patients, First Clinical Product of Company’s Precision Cell Therapy Platform

    Tevogen Bio announced positive topline results from its Proof-of-Concept clinical trial designed to evaluate the safety and feasibility of TVGN 489, the company’s first clinical product of its precision T Cell therapy platform, for the treatment of acute high-risk COVID-19 patients.
    [Tevogen Bio (Business Wire, Inc.)]

    Press Release
    FEATURED EVENT

    Skin-Immune Crosstalk

    February 13 – 16, 2023
    Breckenridge, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Regenerative Therapies

    Dresden University of Technology – Dresden, Germany

    Postdoctoral Scholar Positions – Stem Cell-Based Therapy

    UCLA Jules Stein Eye Institute – Los Angeles, California, United States

    Postdoctoral Scholar Position – Cancer Drug Resistance

    University of California Los Angeles – Los Angeles, California, United States

    Research Scientist – Pancreas Tissue Engineering

    Aspect Biosystems – Vancouver, British Columbia, Canada

    Postdoctoral Fellowship – Systems Biology

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    > See All Jobs

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