| Vol. 24.02 – 23 January, 2023 |
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| Investigators evaluated escalating doses of ALLO-715 after lymphodepletion with an anti-CD52 antibody-containing regimen in 43 patients with relapsed/refractory multiple myeloma. [Nature Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers engineered T cells to express a muscle-specific tyrosine kinase (MuSK) chimeric autoantibody receptor with CD137-CD3ζ signaling domains for precision targeting of B cells expressing anti-MuSK autoantibodies. [Nature Biotechnology] |
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| Scientists used C57BL/6J mice of different ages to carry out the and extracted adipose-derived stem cells from young mice as donors. They further analyzed the species composition of intestinal microorganisms. [Stem Cells And Development] |
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| The authors investigated contribution of the immune system, especially Tregs, to the mechanism whereby human induced pluripotent stem cell transplantation ameliorated white matter infarct. [Journal of Neuroinflammation] |
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| Investigators reported on the outcomes of 110 patients, median age 57 years, who had become dialysis-dependent pre-autologous stem cell transplantation (ASCT) and who underwent a first ASCT. [Bone Marrow Transplantation] |
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| Successful engraftment of bone marrow mesenchymal stem cell (MSC) to the new bone formation occured in collagenase-integrated-bone marrow transplantation (BMT) mice, while routine BMT mice did not recruit bone marrow MSC. [JBMR Plus] |
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| Researchers reported the repair of fully transected radial nerves in 10 Rhesus Macaques using viable, whole sciatic nerve from genetically engineered, designated pathogen free porcine donors. [Xenotransplantation] |
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| To better understand how astrocytes acquire their unique features, scientists transplanted immature mouse cortical astrocytes into the developing cortex of mice and assessed their integration, maturation, and survival. [Journal Of Neuroscience] |
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| Researchers explored the feasibility of using the peritoneum as a support for the precise transplantation of adipose-derived stem cell sheets during surgery. [Heliyon] |
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| Scientists discuss challenges pertaining to cell sources, functional and safety testing, manufacturing, and address clinical-trial design to advance the development of cell therapies for Parkinson’s disease. [Nature Biomedical Engineering] |
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| Investigators discuss the current status and limitations of stem cells and cell-derived exosomes/micro RNAs based cardiac therapy, and evaluate the advantages and disadvantages of the relevant nanomaterials. [Small] |
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| The authors review CAR-based adoptive cell transfer therapeutic areas other than oncology such as infection, allergy, autoimmunity, transplantation, and fibrotic repair. [European Journal Of Immunology] |
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| Tevogen Bio announced positive topline results from its Proof-of-Concept clinical trial designed to evaluate the safety and feasibility of TVGN 489, the company’s first clinical product of its precision T Cell therapy platform, for the treatment of acute high-risk COVID-19 patients. [Tevogen Bio (Business Wire, Inc.)] |
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| February 13 – 16, 2023 Breckenridge, Colorado, United States |
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| Dresden University of Technology – Dresden, Germany |
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| UCLA Jules Stein Eye Institute – Los Angeles, California, United States |
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| University of California Los Angeles – Los Angeles, California, United States |
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| Aspect Biosystems – Vancouver, British Columbia, Canada |
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| The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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