 | | Vol. 24.03 – 30 January, 2023 |
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| To decipher human intestinal–immune crosstalk during development, scientists generated human intestinal organoids (HIOs) containing immune cells by transplanting HIOs under the kidney capsule of mice with a humanized immune system.
[Nature Biotechnology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed, using multiple approaches including parabiosis of mice with graft-versus-host disease (GVHD), that GVHD was primarily maintained locally within diseased tissues.
[Immunity] |
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| An injectable stem cell vector was prepared by combining natural alginate hydrogel and Au@Pt nanoparticles to encapsulate brown adipose stem cells.
[ACS Nano] |
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| The authors showed that CAR signaling occured in the absence of LCK. This LCK-independent signaling required the related SRC family kinase FYN and a CD28 intracellular domain within the CAR.
[Cell Reports Medicine] |
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| Scientists tested anti-CD19 CAR-T cells in a B cell–dependent experimental autoimmune encephalomyelitis model that was responsive to anti-CD20 B-cell depletion similar to the clinical benefit of anti-CD20 monoclonal antibody treatment in multiple sclerosis.
[Neurology-Neuroimmunology & Neuroinflammation] |
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| The authors investigated the feasibility of constructing a small vascular graft from decellularized amniotic membranes (DAMs). The genipin-crosslinked DAM graft showed an improved integrated structure, prolonged stability, proper mechanical property, and superior biocompatibility.
[Biofabrication] |
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| Scientists investigated the engraftment of murine fetal liver cells in newborn hemophilia A (HA) mice for obtaining a suitable “proof of concept” for the development of a new HA treatment in neonates.
[Haematologica] |
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| Data suggested that haploidentical transplant may be an alternative to consolidation chemotherapy as post-remission therapy in patients with intermediate or high-risk acute myeloid leukemia.
[Bone Marrow Transplantation] |
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| Researchers showed that pancreatic islets could become incorporated and function in a non-thermal irreversible electroporation-generated ECM niche, albeit at a low success rate.
[Radiology and Oncology] |
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| Scientists discuss recent results on the biology of engineered T-cells that have been obtained with real-time imaging microscopy.
[Seminars in Immunopathology] |
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| Immusoft announced that the California Institute for Regenerative Medicine had awarded the company an $8M grant.
[Immusoft] |
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| Bristol Myers Squibb announced topline results from TRANSCEND CLL 004, a Phase I/II, open-label, single-arm, multicenter study evaluating Breyanzi in adults with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.
[Bristol Myers Squibb] |
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| February 12 – 15, 2023
Santa Fe, New Mexico, United States |
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| | Umeå University – Umeå, Sweden |
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| | Dresden University of Technology – Dresden, Germany |
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| | UCLA Jules Stein Eye Institute – Los Angeles, California, United States |
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| | The Ottawa Hospital – Ottawa, Ontario, Canada |
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| | Michigan State University – East Lansing, Michigan, United States |
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