Cell Therapy News Volume 24.05 | Feb 13 2023

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    2023-02-13 | CTN 24.05


    Cell Therapy News by STEMCELL Technologies
    Vol. 24.05 – 13 February, 2023
    TOP STORY

    A Biomimetic Nanoplatform for Customized Photothermal Therapy of HNSCC Evaluated on Patient-Derived Xenograft Models

    Various biomimetic nanoplatforms were fabricated by coating the cancer cell membrane of head and neck squamous cell carcinoma (HNSCC) cell lines and patient-derived cells on the surface of Au@C nanoparticles.
    [International Journal of Oral Science]

    Full Article
    Learn how to optimize genome editing conditions for CD34+ cells, evaluate genome editing efficiency, and much more!
    PUBLICATIONSRanked by the impact factor of the journal

    Spinal Cord Tissue Engineering via Covalent Interaction between Biomaterials and Cells

    Scientists demonstrated a combined strategy based on covalent conjugation between biomaterials and various cells to promote neural regeneration after spinal cord injury.
    [Science Advances]

    Full ArticlePress Release

    Increased PRL-1 in Bone Marrow-Derived Mesenchymal Stem Cells Triggers Anaerobic Metabolism via Mitochondria in a Cholestatic Rat Model

    Compared to naïve cells, bone marrow-mesenchymal stem cell phosphatase of regenerating liver-1 (PRL-1) showed an improved antioxidant capacity and mitochondrial dynamics and decreased cellular senescence.
    [Molecular Therapy – Nucleic Acids]

    AbstractGraphical Abstract Press Release

    HLA-Haploidentical Hematopoietic Stem Cells Transplantation with Regulatory and Conventional T Cell Adoptive Immunotherapy in Pediatric Patients with Very High-Risk Acute Leukemia

    Researchers presented outcomes of a novel HLA-haploidentical hematopoietic stem cell transplantation strategy with adoptive immunotherapy with thymic-derived CD4+CD25+ FoxP3+ regulatory T cells and conventional T cells performed in 20 children with high-risk leukemia.
    [2D Materials]

    Abstract

    Organoids Transplantation as a New Modality to Design Epithelial Signature to Create a Membrane-Protective Sulfomucin-Enriched Segment

    Transplanted organoids were established from sulfomucin-enriched region into the injured recipient epithelium following dextran sulfate sodium-induced colitis and analyzed the engrafted epithelium in mouse model.
    [Journal of Gastroenterology]

    Abstract

    Self-Organization, Quality Control, and Preclinical Studies of Human iPSC-Derived Retinal Sheets for Tissue-Transplantation Therapy

    The authors presented a quality control method and preclinical studies for tissue-sheet transplantation. Self-organizing hPSCs differentiated into both retinal and off-target tissues.
    [Communications Biology]

    Full Article

    Transgenic Skin Biomechanical Properties Following First Lifesaving Epidermal Regeneration Using Combined Gene and Cell Therapy

    Biomechanical properties of the transgenic epidermis showed encouraging results in comparison to both the remaining stable non-transgenic skin as well as healthy controls.
    [Journal of the German Society of Dermatology]

    Full Article

    A Clinical Feasible Stem Cell Encapsulation Ensures an Improved Wound Healing

    Researchers developed a novel biosynsphere technology to encapsulate stem cells in clinically-ready biomaterials with controlled microsphere size.
    [Biomedical Materials]

    Full Article

    Expansion of Large Granular Lymphocytes after Autologous Hematopoietic Stem Cell Transplantation

    Investigators evaluated the clinical impact of large granular lymphocytes (LGLs) lymphocytosis on autologous hematopoietic stem cell transplantation recipients. LGL lymphocytosis was observed in 18 of 197 patients
    [International Journal of Hematology]

    Abstract
    This webinar provides insights and techniques for efficient leukopak sample processing and streamlined cell isolation.
    REVIEWS

    Toward Transplantation of Liver Organoids: From Biology and Ethics to Cost-Effective Therapy

    Recent advances in organoid technology might serve as a solution to overcome the donor liver shortage in the future. Scientists highlight the potential of organoid technology for cell therapy and tissue engineering approaches.
    [Transplantation]

    Full Article
    INDUSTRY AND POLICY NEWS

    Disgraced CRISPR-Baby Scientist’s ‘Publicity Stunt’ Frustrates Researchers

    He Jiankui, the Chinese biophysicist who shocked the world by creating the first children with edited genomes, says research must accept moral and ethical constraints, but is otherwise refusing to speak about the work that landed him in jail for three years.
    [Nature]

    Press Release
    FEATURED EVENT

    ESMO Targeted Anticancer Therapies Congress 2023

    March 6 – 8, 2023
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    JOB OPPORTUNITIES

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    Howard Hughes Medical Institute – Dallas, Texas, United States

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    The University of Konstanz – Konstanz, Germany

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    Fred Hutchinson Cancer Center – Seattle, Washington, United States

    Postdoctoral Position – Molecular Medicine and Gene Therapy

    Lund University- Lund, Sweden

    Postdoctoral Fellowships – Protein Chemistry & CAR-T Cell Therapy

    Ume̴ University РUme̴, Sweden

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