Cell Therapy News Volume 24.06 | Feb 27 2023

February 27, 2023

2023-02-27 | CTN 24.06

Cell Therapy News by STEMCELL Technologies

Vol. 24.06 – 27 February, 2023

TOP STORY

T Cell Egress via Lymphatic Vessels Is Tuned by Antigen Encounter and Limits Tumor Control

Researchers investigated whether lymphatic vessel-mediated effector CD8+ T cell egress limited the accumulation of a broad repertoire of functional CD8⁺ T cells.
[Nature Immunology]

Full Article Press Release

PUBLICATIONSRanked by the impact factor of the journal

Metformin-Containing Hydrogel Scaffold to Augment CAR-T Therapy against Post-Surgical Solid Tumors

Investigators designed a hydrogel scaffold to co-deliver metformin and CAR-T cells by adding CAR-T cells into a lyophilized alginate hydrogel containing metformin.
[Biomaterials]

Abstract

Nanoparticle-Mediated Targeting of the Fusion Gene RUNX1/ETO in t(8; 21)-Positive Acute Myeloid Leukemia

Scientists described the use of siRNA-loaded lipid nanoparticles for the specific therapeutic targeting of the leukemic fusion gene RUNX1/ETO.
[Leukemia]

Full Article

Human Gene-Engineered Calreticulin Mutant Stem Cells Recapitulate MPN Hallmarks and Identify Targetable Vulnerabilities

Researchers described the first human gene-engineered model of CALR mutant myeloproliferative neoplasms (MPN) using a CRISPR/Cas9 and adeno-associated viral vector-mediated knock-in strategy to establish a reproducible and trackable phenotype in vitro and in xenografted mice.
[Leukemia]

Full Article

Engineering Inflammation-Resistant Cartilage: Bridging Gene Therapy and Tissue Engineering

TGF-β-activated kinase 1 (TAK1)-KO chondrocytes encapsulated into a hyaluronan hydrogel deposited copious cartilage extracellular matrix proteins and facilitated integration onto native cartilage, even under pro-inflammatory conditions.
[Advanced Healthcare Materials]

Abstract

Fibronectin-Enriched Interface Using a Spheroid-Converged Cell Sheet for Effective Wound Healing

Investigators developed a microstructure patch that could culture a unique human mesenchymal stem cell complex, spheroid-attached cell sheets. Human mesenchymal stem cell complex engraftment was significantly improved, leading to robust wound-healing outcomes in a mouse wound model.
[ACS Applied Materials & Interfaces]

Abstract Graphical Abstract

Dysfunctional Mitochondria Accumulate in a Skeletal Muscle Knockout Model of Smn1, the Causal Gene of Spinal Muscular Atrophy

Scientists showed that survival motor neuron (SMN) loss in mouse skeletal muscle led to the accumulation of dysfunctional mitochondria.
[Cell Death & Disease]

Full Article

Thrombotic Microangiopathy Following Chimeric Antigen Receptor T Cell Therapy

Two cases of thrombotic microangiopathy following CAR-T treatment were reported here. In each case, clinical evidence of kidney injury, thrombocytopenia, and hemolytic anemia became apparent two–three months following CAR-T infusion.
[Cell Death & Disease]

Abstract

CD146⁺ Umbilical Cord Mesenchymal Stem Cells Exhibit High Immunomodulatory Activity and Therapeutic Efficacy in Septic Mice

Researchers compared the regulatory effects of CD146^±umbilical cord mesenchymal stem cells on T cell populations of peripheral blood mononuclear cells and their effects on the macrophage.
[Journal Of Inflammation Research]

Full Article

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REVIEWS

Cell-Based Therapies Have Disease-Modifying Effects on Osteoarthritis in Animal Models. A Systematic Review by the ESSKA Orthobiologic Initiative. Part 2: Bone Marrow-Derived Cell-Based Injectable Therapies

The authors determine if bone marrow-derived cell-based injectable therapies induce disease-modifying effects in joints affected by osteoarthritis in animal models.
[Knee Surgery, Sports Traumatology, Arthroscopy]

Full Article

INDUSTRY AND POLICY NEWS

LIfT BioSciences and Minaris Regenerative Medicine Enter into a Development and Manufacturing Partnership for N-LIfT Allogeneic Neutrophil Based Cell Therapy

LIfT BioSciences entered into a development and manufacturing partnership for N-LIfT, LIfT’s first-in-class neutrophil progenitor based Leukocyte Infusion Therapy for the treatment of various cancer indications, including Pancreatic Cancer, Lung Cancer, and other solid tumors.
[LIfT Biosciences ]

Press Release

Altamira Therapeutics Files Provisional Patent Application for OligoPhore Nanoparticles Targeting Different KRAS Mutations in Cancer Treatment

Altamira Therapeutics, Ltd. announced that it had filed a provisional patent application with the United States Patent and Trade Office to provide broad coverage of different KRAS mutations in human cancer treatment with nanoparticles comprising the Company’s OligoPhore^™ platform and a single siRNA sequence.
[Altamira Therapeutics, Ltd.]

Press Release

Dr. Fred Appelbaum Receives Lifetime Achievement Award

Dr. Fred Appelbaum, executive vice president of Fred Hutchinson Cancer Research Center, was honored by his peers with a Lifetime Achievement award.
[Fred Hutchinson Cancer Center]

Press Release

FEATURED EVENT

Cell Therapy News Volume 24.06 | Feb 27 2023

T Cell Egress via Lymphatic Vessels Is Tuned by Antigen Encounter and Limits Tumor Control

Metformin-Containing Hydrogel Scaffold to Augment CAR-T Therapy against Post-Surgical Solid Tumors

Nanoparticle-Mediated Targeting of the Fusion Gene RUNX1/ETO in t(8; 21)-Positive Acute Myeloid Leukemia

Human Gene-Engineered Calreticulin Mutant Stem Cells Recapitulate MPN Hallmarks and Identify Targetable Vulnerabilities

Engineering Inflammation-Resistant Cartilage: Bridging Gene Therapy and Tissue Engineering

Fibronectin-Enriched Interface Using a Spheroid-Converged Cell Sheet for Effective Wound Healing

Dysfunctional Mitochondria Accumulate in a Skeletal Muscle Knockout Model of Smn1, the Causal Gene of Spinal Muscular Atrophy

Thrombotic Microangiopathy Following Chimeric Antigen Receptor T Cell Therapy

CD146⁺ Umbilical Cord Mesenchymal Stem Cells Exhibit High Immunomodulatory Activity and Therapeutic Efficacy in Septic Mice

Cell-Based Therapies Have Disease-Modifying Effects on Osteoarthritis in Animal Models. A Systematic Review by the ESSKA Orthobiologic Initiative. Part 2: Bone Marrow-Derived Cell-Based Injectable Therapies

LIfT BioSciences and Minaris Regenerative Medicine Enter into a Development and Manufacturing Partnership for N-LIfT Allogeneic Neutrophil Based Cell Therapy

Altamira Therapeutics Files Provisional Patent Application for OligoPhore Nanoparticles Targeting Different KRAS Mutations in Cancer Treatment

Dr. Fred Appelbaum Receives Lifetime Achievement Award

Cancer Immunotherapy: Mechanisms of Response versus Resistance

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Director – Cell Therapy Research Operations

Staff Scientist – Frankfurt Cancer Institute Organoid Biobank

Research Officer – Bioinformatics

Postdoctoral Research Fellow – Cancer Biology

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