 | | Vol. 24.08 – 13 March, 2023 |
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| Functional validation of established CAR-T cells shows robust in vitro and in vivo efficacy in cell line- and human-derived acute myeloid leukemia models with minimal off-target toxicity toward relevant healthy human tissues.
[Nature Biotechnology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists used cryo-electron microscopy to determine the protein structure of several CAR binders complexed with the extracellular portion of human CD19, a target antigen found on B cell malignancies.
[Science Immunology] |
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| To overcome the limitations of analyzing minute embryo DNA, researchers validated gene editing outcomes in stable embryonic stem cells derived from targeted human embryos.
[Nature Communications] |
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| Scientists provided evidence of the efficacy and feasibility of a novel approach to treat CLN1 disease and possibly other neurodegenerative conditions, paving the way for its future clinical application.
[EMBO Molecular Medicine] |
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| Researchers identified a link between miRNA regulation, ribosome biogenesis, and protein synthesis during newt limb regeneration.
[Developmental Cell] |
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| Investigators performed a retrospective analysis of 98 pediatric patients with Fanconi anemia who were transplanted between July 1990 to June 2020 to evaluate the incidence of gonadal dysfunction in female and male patients with Fanconi anemia.
[Haematologica] |
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| This observational, cross-sectional study assessed the prevalence of hypothyroidism in adult allo-stem cell transplantation recipients according to time from transplantation, and to identify risk factors.
[Journal Of Endocrinological Investigation] |
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| Scientists suggested the CAR T cells could specifically eliminate Tn-MUC1-positive intrahepatic cholangiocarcinoma cells, but not Tn-MUC1-negative intrahepatic cholangiocarcinoma cells, in vitro and in vivo.
[Journal Of Immunotherapy] |
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| Researchers evaluated the safety and efficacy of bone marrow-derived mononuclear cell implantation in critical limb-threatening ischemia patients with thromboangiitis obliterans.
[Circulation Journal] |
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| The authors oversee the potential benefit of reinforcement of immunotherapy for neuroblastoma following hematopoietic cell transplantation, focusing primarily on lymphocytes and dendritic cells.
[Critical Reviews In Oncology/Hematology] |
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| Vertex Pharmaceuticals, Inc. announced that the US FDA had cleared the IND for VX-264, a stem cell-derived, fully differentiated pancreatic islet cell therapy encapsulated into a Vertex-developed, immunoprotective device with the potential to treat type 1 diabetes.
[Vertex Pharmaceuticals, Inc.] |
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| The birth of babies with genomes edited by Chinese biophysicist He Jiankui has prompted China and other nations to tighten oversight of such germline editing.
[Science] |
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| March 26 – 29, 2023
Snowbird, Utah, United States |
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| | Leiden University – Leiden, Netherlands |
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| | The German Cancer ReÂsearch Center – Heidelberg, Germany |
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| | ETH Zurich – Zurich, Switzerland |
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| | City of Hope – Duarte, California, United States |
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| | Rutgers Cancer Institute of New Jersey – New Brunswick, New Jersey, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
