 | | Vol. 24.09 – 20 March, 2023 |
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| In a B cell lymphoma patient cohort from five centers in Germany and the United States, the authors demonstrated that wide-spectrum antibiotics treatment prior to CD19-targeted CAR-T cell therapy was associated with adverse outcomes.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Clinical effect of donor-derived natural killer cell infusion after HLA-haploidentical hematopoietic cell transplantation (HCT) was evaluated in high-risk myeloid malignancy in Phase 2, randomized trial.
[Leukemia] |
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| Scientists showed that activated donor T cells expressed galectin-3 (Gal-3) after allo-HCT. In both major and minor histocompatibility-mismatched models of murine acute graft versus host disease expression of Gal-3 is associated with decreased T cell activation and suppression of the secretion of effector cytokines.
[Cell Reports] |
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| Investigators tested a clinically proven BTM, a polyurethane-based scaffold, to generate a well-vascularized intracutaneous “neo-dermis” within the skin for islet transplantation.
[Diabetes] |
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| Researchers investigated the effectiveness of deer antler stem cells conditioned medium for the repair of surgically-created alveolar bone defects using a rat model and sought to define the underlying mechanisms.
[Cell Proliferation] |
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| Given recent discoveries of nanoparticle strategies in improving macrophage survival and promoting phenotype retention, investigators reported the ability to extend the survival and phenotype of macrophage transplants in murine lungs via pre-treatment with nanoparticles of varying degradation rates.
[Drug Delivery And Translational Research] |
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| Scientists selected patients with the following characteristics: CART or allogeneic hematopoietic cell transplantation (alloHCT) performed between 2016 and 2021; ≥18 years old; ABCL diagnosis; ≥2 lines of therapy; and either anti-CD19 CART or alloHCT as therapy at relapse.
[Bone Marrow Transplantation] |
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| Investigators evaluated the efficacy of salvage treatments for relapsed or refractory diffuse large B cell lymphoma through meta-analysis.
[Cancer Research And Treatment] |
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| Scientists engineered clonal human bone marrow mesenchymal stem/stromal cell (cBMSC) sheets and determined the influence of cBMSC freeze-thawing on both in vitro production of pro-regenerative factors and in vivo ability to reduce renal fibrosis in a rat model compared to freshly harvested cBMSCs.
[Scientific Reports] |
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| Investigators evaluate the evolving role of allogeneic hematopoietic stem cell transplantation in the CAR T era, and discuss lessons learned from the first steps with CAR T in acute lymphoblastic leukemia.
[Blood Advances] |
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| The authors outline the potential and possibilities of using CRISPR/Cas9-based gene-editing technology in cystic fibrosis modeling.
[Advances In Medical Sciences] |
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| Vaccitech plc announced topline interim data from the HPV001 study, a Phase Ib/II clinical trial of VTP-200 in women with low-grade cervical HPV lesions.
[Vaccitech plc] |
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| April 14 – 19, 2023
Orlando, Florida, United States |
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| | Delft University of Technology – Delft, Netherlands |
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| | The German Cancer Research Center – Heidelberg, Germany |
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| | ETH Zurich – Zurich, Switzerland |
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| | City of Hope – Duarte, California, United States |
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| | Rutgers Cancer Institute of New Jersey – New Brunswick, New Jersey, United States |
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