Cell Therapy News Volume 24.12 | Apr 5 2023

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    2023-04-10 | CTN 24.12


    Cell Therapy News by STEMCELL Technologies
    Vol. 24.12 – 10 April, 2023
    TOP STORY

    Gene Editing to Prevent Ventricular Arrhythmias Associated with Cardiomyocyte Cell Therapy

    When transplanted in vivo, human pluripotent stem cell-derived cardiomyocyte cells engrafted and coupled electromechanically with host cardiomyocytes without causing sustained engraftment arrhythmias.
    [Cell Stem Cell]

    AbstractGraphical AbstractPress Release
    CRISPR-Cas Genome Editing Applications for Disease Modeling and Cell Therapy. Click to download.
    PUBLICATIONSRanked by the impact factor of the journal

    TSTEM-Like CAR-T Cells Exhibit Improved Persistence and Tumor Control Compared with Conventional CAR-T Cells in Preclinical Models

    Scientists demonstrated that functional stem-like T (TSTEM) cells were less abundant in infused CAR-T cell products in a phase I clinical trial testing Lewis Y-CAR-T cells, and the infused CAR-T cells displayed poor persistence in patients.
    [Science Translational Medicine]

    AbstractPress Release

    The IgG4 Hinge with CD28 Transmembrane Domain Improves VHH-Based CAR T Cells Targeting a Membrane-Distal Epitope of GPC1 in Pancreatic Cancer

    Investigators developed CAR T cells targeting glypican-1 (GPC1), an oncofetal antigen expressed in pancreatic cancer.
    [Nature Communications]

    Full Article

    Engineering Tumor-Specific Gene Nanomedicine to Recruit and Activate T Cells for Enhanced Immunotherapy

    Scientists devised tumor-specific gene nanomedicines to mobilize tumor cells to secrete CXCL9 and anti-PD-L1 scFv for enhanced immunotherapy.
    [Nature Communications]

    Full Article

    Synergistic Effects of Combined Immunotherapy Strategies in a Model of Multifocal Hepatocellular Carcinoma

    Researchers developed a multifocal hepatocellular carcinoma model to test immunotherapies by introducing c-myc using hydrodynamic gene transfer along with CRISPR-Cas9-mediated disruption of p53 in mouse hepatocytes.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    ROS-Activatable Nanocomposites for CT Imaging Tracking and Antioxidative Protection of Mesenchymal Stem Cells in Idiopathic Pulmonary Fibrosis Therapy

    ROS-activatable nanocomposites enabled continuous computer tomography (CT) imaging tracking of the transplanted MSCs for 21 days in idiopathic pulmonary fibrosis treatment, obtaining the location and distribution of the transplanted mesenchymal stem cells.
    [Journal of Controlled Release]

    AbstractGraphical Abstract

    Transplantation-Based Screen Identifies Inducers of Muscle Progenitor Cell Engraftment across Vertebrate Species

    The authors reported the development and application of a cross-species small-molecule screening platform employing zebrafish and mice direct evaluation of the effects of chemical compounds on the engraftment of transplanted muscle precursor cells.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Identifying Early Infections in the Setting of CRS with Routine and Exploratory Serum Proteomics and the HT10 Score Following CD19 CAR-T for Relapsed/Refractory B-NHL

    Researchers investigated the challenge of identifying early infections in patients who developed a fever after CAR-T therapy.
    [HemaSphere]

    Full ArticleGraphical Abstract

    Therapeutic Effects of Anti-GM2 CAR-T Cells Expressing IL-7 and CCL19 for GM2-Positive Solid Cancer in Xenograft Model

    Using interleukin (IL)-7 and chemokine ligand 19 (CCL19)-producing human CAR-T system, the authors explored the possibility of GM2 as a solid tumor target for CAR-T cell therapy in a mouse model with human small-cell lung cancer.
    [Cancer Medicine]

    Full Article

    Transplantation of Insulin-Producing Cells Derived from Human MSCs to Treat Diabetes in a Non-Human Primate Model

    Scientists investigated whether human umbilical cord-derived mesenchymal stem cells could effectively differentiate into insulin-producing cells (IPCs), and evaluated the therapeutic efficacy of IPCs in treating diabetes.
    [Artificial Organs]

    Abstract
    Explore this validated protocol for high-efficiency CRISPR-Cas9 gene editing of Human Primary T Cells.
    REVIEWS

    In Vitro, Ex Vivo, and In Vivo Models for Dental Pulp Regeneration

    Investigators explore the evolution of laboratory models used in such studies and classify them according to different criteria in relation to tissue engineering for pulp regeneration.
    [Journal Of Materials Science-Materials In Medicine]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Western Research Projects Receive over $9 Million in Federal Grants

    The Canadian Institutes of Health Research awarded $9.4 million in federal funding to 17 Western researchers for their innovations in medical and health studies.
    [Western University]

    Press Release
    FEATURED EVENT

    Type 2 Diabetes: Understanding Its Early Drivers and the Road to Therapeutics

    May 1 – 4, 2023
    Palm Springs, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – CAR T Cell Immune Therapies

    Imperial College London – London, England, United Kingdom

    Postdoctoral Positions – Cell Therapy and Cancer Biology

    Medical University of South Carolina – Charleston, South Carolina, United States

    Assistant Professor – Stem Cells and Regenerative Medicine

    Ottawa Hospital Research Institute – Ottawa, Ontario, Canada

    Research Fellow – Neuromuscular Disease

    Mayo Clinic – Rochester, Minnesota, United States

    Postdoctoral Fellowship – Cancer Research and Tumor Immunology

    Umeå University – Umeå, Sweden

    > See All Jobs

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