 | | Vol. 24.13 – 17 April, 2023 |
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| With a CRISPR–Cas9 pooled library, researchers performed an in vivo targeted loss-of-function screen and identified ST3 β-galactoside α-2,3-sialyltransferase 1 (ST3GAL1) as a negative regulator of the cancer-specific migration of CAR T cells.
[Nature Immunology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported broad expression of STEAP1 relative to prostate-specific membrane antigen in lethal metastatic prostate cancers and the development of a STEAP1-directed chimeric antigen receptor T cell therapy.
[Nature Communications] |
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| Investigators analyzed the impact of immunometabolic host features and detailed body composition measurements on post-CAR-T clinical outcomes.
[Cancer Immunology Research] |
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| The authors designed a multifunctional urethral patch with appropriate hydrophilicity, desirable antioxidant capacity, and anti-inflammatory property for the repair of urethral defects.
[Advanced Healthcare Materials] |
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| Magneto-mechanical bioengineered cells consisting of magnetic silica nanoparticles and mesenchymal stem cells were prepared to alleviate osteoporosis.
[ACS Applied Materials & Interfaces] |
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| Using translating ribosome affinity purification with sequencing tools, scientists simultaneously decoded the transcriptomes of graft and host for human neural stem cells transplanted into the stroke-injured rat brain.
[Cell Reports] |
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| Researchers introduced a new non-invasive near-infrared fluorescence imaging strategy based on glucose-conjugated quantum dot labeling to target and track extracellular vesicles in a sciatic nerve injury rat model in real-time.
[Nanoscale] |
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| Investigators reported a switchable CAR T cell strategy based on anti-FITC CAR T cells and a switch molecule conjugated with FITC for targeting osteosarcoma tumors.
[Cancer Immunology Immunotherapy] |
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| The authors developed a second-generation CAR construct and generated CAR-T cells targeting CD38 molecules.
[Cancer Medicine] |
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| Scientists give an overview of the history of patient-derived xenograft (PDX) models and the process of PDX model establishment, highlighting its strengths and weaknesses.
[Signal Transduction and Targeted Therapy] |
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| Investigators review recent strategies for promoting in situ tissue regeneration through bone marrow-derived stem cell mobilization or homing in animal models as well as in human trials.
[Stem Cells] |
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| GI Cell announced that it will receive approximately 17.6 billion won, $13.3 million, in research costs for non-clinical research and Phase I clinical approval of Drone Treg for four years.
[GI Cell (Korea Biomedical Review)] |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | Imperial College London – London, England, United Kingdom |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Medical University of South Carolina – Charleston, South Carolina, United States |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
