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| Researchers combined a non-viral CRISPR-Cas9 nuclease-assisted knock-in and Cas9-derived base editing technology for double-strand breaks free knock-outs within a single intervention.
[Genome Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators established a Fab-based adapter CAR (AdCAR) T cell platform with flexibility of targeting and control of AdCAR T cell activation.
[Leukemia] |
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| The authors developed a myeloid cell-based strategy to reduce the disease burden in experimental autoimmune encephalomyelitis, a mouse model of progressive multiple sclerosis.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| A novel biomimetic periodontal ligament transplantation composed of human periodontal ligament stem cells pretreated with gold nanocomplexes and embedded in a type-I collagen hydrogel scaffold was developed to protect alveolar bone from resorption.
[Advanced Healthcare Materials] |
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| | Data were collected from patients who received at least one cycle of brentuximab vedotin maintenance after autologous stem cell transplant with primary refractory disease, extra-nodal disease, or relapse < 12 months from the end of frontline therapy.
[Haematologica] |
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| Co-expression of Fas-CD40 with either 4-1BB- or CD28-containing CARs increased in vitro efficacy by augmenting CAR T cell proliferation and cancer target cytotoxicity, and enhanced tumor killing and overall mouse survival in vivo.
[Molecular Therapy – Nucleic Acids] |
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| Scientists launched a Phase I trial to explore differences between autologous and allogeneic anti-CD7 CAR-T therapies in T cell acute lymphoblastic leukemia and lymphoma.
[Blood Cancer Journal] |
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| Researchers suggested that TNF-α/IL-1β pretreatment enhances the efficacy of adipose tissue-derived stem cells in mice with cholestatic liver injury, partially through the COX-2/PGE2 pathway.
[Stem Cell Research & Therapy] |
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| Investigators designed a system to control the proliferation and activation state of CARs based on downstream NFAT transcription factors.
[Molecular Therapy Oncolytics] |
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| The authors summarize recent advances in engineering Treg cells, including the concept of biosensors for inflammation, and assess Treg cell engineering possibilities for novel functional units, including Treg cell modifications influencing stability, migration, and tissue adaptation.
[Trends In Immunology] |
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Ossium Health, Inc. announced that the CIRM has awarded the company a $3.46M Clinical Stage Research Program grant to support the continued clinical development of OSSM-007, Ossium’s interferon-gamma primed mesenchymal stem cell product, for the treatment of steroid-refractory GVHD.
[Ossium Health, Inc. (Business Wire)] |
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| June 2 – 6, 2023
Chicago, Illinois, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee |
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| | Institute for Bioengineering of Catalonia – Barcelona, Spain |
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| | Wake Forest University – Winston Salem, North Carolina, United States |
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| | Delft University of Technology – Delft, Netherlands |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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