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| Scientists reported a combinatorial strategy to treat bone metastatic castrate-resistant prostate cancer using γδ-enriched CAR-T cells and zoledronate.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators constructed an artificial three-dimensional biomimetic scaffold-based mesenchymal stem cells implant to establish a beneficial regeneration niche for endogenous stem cells in situ lung regeneration.
[Bioengineering & Translational Medicine] |
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| The authors showed that low-dose total body irradiation delivered to acute lymphoblastic leukemia-bearing mice before CAR T cell infusion considerably extended the overall survival benefit afforded by CAR T cells alone.
[Cell Death & Disease] |
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| Scientists detected high human epidermal growth factor receptor 2 (HER2) cell surface protein across a panel of patient-derived diffuse intrinsic pontine glioma (DIPG) cells, thereby identifying an existing CAR T cell therapy for use in DIPG.
[Neuro-Oncology Advances] |
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| Researchers employed neural stem cells (NSCs) derived from human induced pluripotent stem cells together with exosomes extracted from NSCs to treat cerebral ischemia induced by middle cerebral artery occlusion/reperfusion in mice.
[eLife] |
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| Scientists conducted a multicentre real-world retrospective analysis of the use of CD19 CAR-T therapy in relapsed/refractory solid organ transplantation-related post-transplant lymphoproliferative disorders (PTLD) to provide guidance on treatment safety, efficacy, and patient prognostication.
[British Journal Of Haematology] |
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| Investigators examined the expression of B7-H3 in prostate cancer tissues and cells and developed a second-generation CAR that specifically targeted B7-H3 and CD28 as costimulatory receptor to explore its tumoricidal potential against prostate cancer in vitro and in vivo.
[Cell Death Discovery] |
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| The authors analyzed a time course of transplanted human intestinal organoids (HIOs) histologically at 2, 4, 6, and 8 weeks post-transplantation, and demonstrated that HIO maturation closely resembled key stages of fetal human intestinal development.
[Development] |
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| Researchers presented spatial transcriptomics analysis of fully differentiated grafts in their host tissue. They observed that cells derived from human embryonic stem cells (hESC) in the grafts adopted mature dopaminergic signatures.
[Molecular Therapy-Methods & Clinical Development] |
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| The authors focus on the engineering of non-viral gene delivery nanoparticles for transducing CAR into T cells ex vivo/in vitro or in vivo.
[Acta Biomaterialia] |
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| Bristol Myers Squibb announced that the European Commission has granted approval for Breyanzi, a CD19-directed CAR T cell therapy, for relapsed or refractory large B cell lymphoma after one prior therapy.
[Academic Pediatrics] |
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May 28 – 31, 2023
Killarney, Ireland |
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| | Weill Cornell Medical College – New York, New York, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | The University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States |
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| | Institute for Bioengineering of Catalonia – Barcelona, Spain |
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| | Wake Forest University – Winston Salem, North Carolina, United States |
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