 | | Vol. 24.17 – 15 May, 2023 |
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| The authors developed an in vivo xenotransplantation approach that allowed for the study of functionally mature human microglia that operated within a physiologically relevant, vascularized immunocompetent human brain organoid model.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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Researchers reported a temperature-sensitive genome-editing nanodevice that could deliver a Cas9 editor with an external trigger which could be used to edit the genome of tumor cells to reduce resistance to apoptosis and modulate the tumor microenvironment via a mild heating trigger.
[Nature Nanotechnology] |
| | The authors reported that NEXT was a potent strategy for precision tissue repair. Large amounts of extracellular vesicles with higher yield/purity could be readily isolated from desired tissues with less production time/cost compared to the conventional cell culture-based method.
[Advanced Materials] |
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| To expand the targeting capabilities of these receptors, researchers developed “universal” receptor systems for which receptor specificity could be directed post-translationally via covalent attachment of a co-administered antibody bearing a benzylguanine motif.
[Nature Communications] |
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| In order to explore an effective treatment that could achieve multi-dimensional repair of the injured cornea, the authors combined modified mRNA technologies with adipose-derived mesenchymal stem cell therapy.
[Molecular Therapy] |
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| Through the use of single-cell analysis and transplantation assays, investigators provided evidence of Jagged1 as a novel niche factor for fetal liver hematopoietic stem cells.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Clinical-grade human umbilical cord-derived mesenchymal stem cells were administrated to two classic mouse models, and their effects on skeletal muscle mass and function were investigated by behavioral tests, immunostaining, and western blotting.
[Cell Death & Disease] |
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| In xenografted mice, CART-38-mediated rejection of acute myeloid leukemia, T cell acute lymphoblastic leukemia, and multiple myeloma cell lines and primary samples and prolonged survival.
[Blood Advances] |
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| Investigators transplanted human retinal organoid-derived cells into photoreceptor-deficient mice and conducted histology and single-cell RNA sequencing alongside time-matched cultured retinal organoids.
[Stem Cell Reports] |
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| Scientists showed erythropoietin treatment after transplantation reduced ischemic damage in transplanted ovarian tissue, increased angiogenesis, maintenance of ovarian follicle proliferation, and reduced fibrosis areas in the grafted tissue.
[Reproductive BioMedicine Online] |
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| Investigators focus on recent research advances in stem cell therapy for atherosclerosis (AS) and briefly summarize the relevant factors that induce the formation of AS.
[Molecular and Cellular Biochemistry] |
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| The authors discuss potential therapeutic mechanisms of stem cell transplantation for curing hypoxic-ischemic-induced brain injury, summarizing a series of approaches for marking transplanted cells and existing imaging systems for stem cell labeling.
[European Journal of Neuroscience] |
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| ImmPACT Bio USA, Inc. announced the US FDA has granted Fast Track Designation for IMPT-314, a potential first-in-class CD19/CD20 CAR T therapy for the treatment of patients with B cell mediated malignancies.
[ImmPACT Bio USA, Inc. (PRNewswire)] |
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| The Maryland Stem Cell Research Fund Commission has announced over $14.1 million in grant awards to promote innovative research that will strengthen and advance stem cell treatments and technologies in Maryland.
[TEDCO] |
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| June 3 – 7, 2023
San Diego, California, United States |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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| | Boehringer Ingelheim – Ingelheim, Germany |
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| | Max Delbrück Center for Molecular Medicine – Berlin, Germany |
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| | Weill Cornell Medical College – New York, New York, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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