 | | Vol. 24.19 – 5 June, 2023 |
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| In preclinical mouse models, YTB323, a novel autologous CD19-directed CAR T-cell therapy expressing the same validated CAR as tisagenlecleucel, exhibited enhanced in vivo expansion and antitumor activity at lower doses than traditionally manufactured CAR T-cells.
[Cancer Discovery] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Lysophosphatidic acid receptor signaling by CD8 T cells promoted tolerogenic states via metabolic reprogramming and potentiating exhaustive-like differentiation to modulate anti-tumor immunity.
[Nature Communications] |
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| Hypoimmunogenic iPSCs were generated through CRISPR/Cas9 editing of the human leukocyte antigen molecules. Oligodendrocyte progenitor cells were then differentiated and engrafted into the brains of Canavan disease mice and exhibited widespread distribution in the brain.
[Advanced Science] |
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| Scientists demonstrated the efficacy and mechanisms of mono- and dual-human pluripotent stem cell-derived cardiovascular progenitor cells- and cardiomyocytes-seeding small intestinal submucosal extracellular matrix for repair of infarcted hearts based on the side-by-side comparison.
[Bioactive Materials] |
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| Even in the absence of a matched sibling donor, outcomes of allogeneic hematopoietic cell transplantation in second complete remission for acute myeloid leukemia have significantly improved over time, with most favorable outcomes achieved with matched unrelated donors.
[Cancer] |
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| Scientists manufactured activation-inducible CAR T cells with the help of CRISPR-mediated targeted integration. This new type of engineered T cells expressed the CAR gene dependent on their activation status.
[Communications Biology] |
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| Investigators established a cellular model system using a CD19-positive B lineage acute lymphoblastic leukemia (B-ALL) cell line Nalm-6 to investigate the treatment options for CD19-negative relapsed B-ALL after CD19-CAR T cell therapy.
[Apoptosis] |
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| Researchers compared m971-CAR with a novel CAR derived from IS7, an antibody that targets a central epitope on CD22. The IS7-CAR has superior avidity, and is active and specific against CD22 positive targets, including B lineage acute lymphoblastic leukemia patient-derived xenograft samples.
[Journal Of Biological Chemistry] |
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| Pretreatment with the recombinant human Klotho protein improved cell survival after human periodontal ligament stem cell transplantation and enhanced their ability to promote bone regeneration.
[Journal Of Orthopaedic Surgery And Research] |
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| Strategies involving the combination of photodynamic therapy and gene therapy were discussed, together with the role of nanocarriers in this synergistic therapeutic approach, including aspects related to the design of nanomaterials and anticancer performance in studies in vitro and in vivo.
[Photodiagnosis And Photodynamic Therapy] |
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| On 22 June, the US Food and Drug Administration would decide whether to grant a fast-track approval to the first gene therapy for Duchenne muscular dystrophy, a genetic disorder that affects around 1 in 3,500 boys.
[Nature] |
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| June 22 – 23, 2022
Oslo, Norway |
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| | King’s College London – London, England, United Kingdom |
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| | Vlaams Instituut voor Biotechnologie – Ghent, Belgium |
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| | Massachusetts Institute of Technology – Cambridge, Massachusetts, United States |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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| | Weill Cornell Medical College – New York, New York, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
