 | | Vol. 24.21 – 19 June, 2023 |
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| The authors used base editing to generate universal, off-the-shelf CAR T cells. Healthy volunteer donor T cells were transduced with the use of a lentivirus to express a CAR with specificity for CD7, a protein that is expressed in T cell acute lymphoblastic leukemia
[New England Journal Of Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators took advantage of a large international multicenter cohort to evaluate the role of TP53MT in patients with myelofibrosis undergoing HSC transplantation.
[Blood] |
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| Researchers used a well-studied mutant c-KIT protein as a co-stimulatory domain to generate CAR T cells with strong IFNγ signaling that were able to overcome the immunosuppressive microenvironment of solid tumors.
[Nature Cancer] |
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| A multifunctional nanocatalyst was prepared by encapsulating horseradish peroxidase-loaded Au/polydopamine nanoparticles and Ag2S quantum dots with CAR T cell membranes to improve the CAR T cell therapy in solid tumors.
[ACS Nano] |
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| Investigators identified that inhibition of transforming growth factor-β (TGF-β) receptor 1 could relieve tumor fibrosis, thus facilitating the recruitment of tumor-infiltrating T lymphocytes.
[Nature Communications] |
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| Scientists utilized both RNA interference and lipid–polymer nanoparticles to engineer a potential multiple myeloma therapy, which targets cyclophilin A within blood vessels of the bone marrow.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers created and characterized diagnostic and therapeutic stem cells, expressing epidermal growth factor receptor (EGFR)-targeted nanobody fused to the extracellular domain of death DR4/5 ligand that simultaneously targeted EGFR and DR4/5, in non-small cell lung cancer tumor models.
[Stem Cells Translational Medicine] |
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| The authors showed that eliminating abnormal bone marrow-derived cells using bone marrow transplantation resulted in controlling serum glucose in diabetic mice, in which normoglycemia was sustained even after cessation of insulin therapy.
[Communications Biology] |
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| Investigators determined the interaction between exogenous and endogenous stem cells during bone healing using a standardized burr-hole bone injury model in a mesenchymal progenitor cell lineage-tracing mouse under normal homeostatic and osteoporotic conditions.
[Scientific Reports] |
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| The authors present recent advances and research efforts on the development of nanoparticle surface engineering toward cancer theranostics, and summarize the general strategies for nanoparticle surface engineering.
[Accounts of Chemical Research] |
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| Scientists describe promising engineering strategies to refine CAR constructs to reverse exhaustion, develop regulatable CARs, optimize manufacturing, enrich immune memory, and disrupt immune inhibition.
[Expert Opinion on Biological Therapy] |
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| Mustang Bio, Inc. announced that final data from the follicular lymphoma (“FL”) cohort of the single-institution Phase I/II clinical trial of MB-106 demonstrated treatment with the CD20-targeted, autologous CAR T cell therapy resulted in high overall response and complete response rates.
[Mustang Bio, Inc.] |
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| Two University of California San Francisco (UCSF) scientists have received Pew awards in the biomedical sciences for their work in immunology as part of a program that supports promising early-career investigators.
[The University of California San Francisco] |
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| Dr. Theodore Moore has received a Pediatric Cancer Research Foundation research grant to conduct Phase I–II therapeutic research trials in children with relapsed cancer where standard therapy no longer works and to study the development of new treatment modalities for incurable brain tumors.
[UCLA] |
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| July 16 – 21, 2023
Holderness, New Hampshire, United States |
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| | University Hospital RWTH Aachen – Aachen, Germany |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | Fred Hutchinson Cancer Center – Seattle, Washington, United States |
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| | VIB Center for Cancer Biology – Leuven, Belgium |
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| | King’s College London – London, England, United Kingdom |
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