Cell Therapy News Volume 24.22 | Jun 26 2023

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    2023-06-26 | CTN 24.22


    Cell Therapy News by STEMCELL Technologies
    Vol. 24.22 – 26 June, 2023
    TOP STORY

    Safety and Clinical Activity of Autologous RNA Chimeric Antigen Receptor T Cell Therapy in Myasthenia Gravis (MG-001): A Prospective, Multicenter, Open-Label, Non-Randomized Phase Ib/IIa Study

    To explore the use of CAR T cells for the treatment of people with autoimmune disease, and to improve their safety, scientists engineered them with RNA —rather than the conventional DNA approach—to target B cell maturation antigen expressed on plasma cells.
    [Lancet Neurology]

    AbstractPress Release
    Who does immunology research in the Bolivian Andes? He does. Read Jason Young's story.
    PUBLICATIONSRanked by the impact factor of the journal

    Direct In Vivo Activation of T Cells with Nanosized Immunofilaments Inhibits Tumor Growth and Metastasis

    The authors engineered nanosized immunofilaments, with a soluble semiflexible polyisocyanopeptide backbone that presented peptide-loaded major histocompatibility complexes and costimulatory molecules multivalently.
    [ACS Nano]

    Full ArticleGraphical Abstract

    Chimeric Antigen Receptor T Cells Targeting FcRH5 Provide Robust Tumor-Specific Responses in Murine Xenograft Models of Multiple Myeloma

    Investigators showed that Fc receptor-homolog 5 (FcRH5) was expressed on multiple myeloma cells and could be targeted with CAR-T cells. FcRH5 CAR-T cells elicited antigen-specific activation, cytokine secretion, and cytotoxicity against multiple myeloma cells.
    [Nature Communications]

    Full Article

    Chimeric Antigen Receptor (CAR) T Cell-Based Targeting of CD317 as a Novel Immunotherapeutic Strategy against Glioblastoma

    Researchers identified the transmembrane protein CD317 as a novel target antigen for CAR T cell therapy against glioblastoma, one of the most aggressive solid tumors.
    [Neuro-Oncology]

    Abstract

    Single-Cell Transcriptomics Reveals Maturation of Transplanted Stem Cell–Derived Retinal Pigment Epithelial Cells toward Native State

    Scientists transplanted stem cell–derived retinal pigment epithelial (RPE) into the subretinal space of immunocompetent rabbits for one month and conducted single-cell RNA sequencing analyses on the explanted RPE monolayers.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    Enhancing CAR T Cell Therapy Using Fab-Based Constitutively Heterodimeric Cytokine Receptors

    Investigators created a new engineered cytokine receptor able to constitutively recreate receptor-heterodimer utilizing the heterodimerization domain derived from the IgG1 antibody.
    [Cancer Immunology Research]

    Abstract

    Rapid Generation of CD19 CAR-T Cells by Minicircle DNA Enables Anti-Tumor Activity and Prevents Fatal CAR-B Leukemia

    Using a virus-free and non-transgenic minicircle DNA vector, the authors enabled the rapid generation of CD19 CAR-T cells within two days.
    [Cancer Letters]

    Abstract

    Vitamin A-Modified ZIF-8 Lipid Nanoparticles for the Therapy of Liver Fibrosis

    In vivo experiments showed that vitamin A-modified zeolitic imidazolate framework-8 (ZIF-8) lipid nanoparticles could reduce liver injury, improve the degree of liver fibrosis (LF), and exert specific therapeutic effects on LF.
    [International Journal Of Pharmaceutics]

    AbstractGraphical Abstract

    Periosteum-Derived Skeletal Stem Cells Encapsulated in Platelet-Rich Plasma Enhance the Repair of Bone Defect

    Scientists established new stem cell-based therapies for treating bone defects by delivering the stem cells sorted from periosteum using flow cytometry within the platelet-rich plasma.
    [Tissue and Cell]

    Full Article
    View tips on how to share lab duties effectively.
    REVIEWS

    Progress and Perspective of CRISPR-Cas9 Technology in Translational Medicine

    Investigators present the latest CRISPR-Cas9 technology achievements and prospect to translational medicine advances.
    [Advanced Science]

    Full Article

    Advance in Nanomedicine for Improving Mucosal Penetration and Effective Therapy of Cervical Cancer

    Scientists introduce the physiological state of the cervicovaginal cavity and the characteristics of the intravaginal environment in cervical cancers and discuss both “first mucus-adhering then mucosal penetration” and “first mucus-penetrating then mucosal penetration” strategies.
    [Small]

    Abstract

    Delivering CAR-T Cells into Solid Tumors via Hydrogels

    The authors introduce different design strategies of CAR-T cell delivery hydrogels and discuss various types of therapeutic agents incorporated in the hydrogel platforms and diverse hydrogel formulations.
    [MedComm]

    Full Article
    INDUSTRY AND POLICY NEWS

    Sarepta Therapeutics Announces FDA Approval of ELEVIDYS, the First Gene Therapy to Treat Duchenne Muscular Dystrophy

    Sarepta Therapeutics, Inc. announced US FDA accelerated approval of ELEVIDYS, an adeno-associated virus based gene therapy for the treatment of ambulatory pediatric patients aged 4 through 5 years with Duchenne muscular dystrophy (DMD) with a confirmed mutation in the DMD gene.
    [Sarepta Therapeutics, Inc.]

    Press Release

    New EIC Project to Improve CAR T Therapies in Solid Tumors

    Partners in the international consortium CAR T-REX announced the awarding of a highly competitive European Innovation Council (EIC) Pathfinder Open grant, following the positive evaluation of their project entitled ‘CAR T Cells Rewired to Prevent EXhaustion in the Tumor Microenvironment’.
    [Center For Research In Biological Chemistry and Molecular Materials]

    Press Release
    FEATURED EVENT

    Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases

    July 17 – 20, 2023
    Burlington, Vermont, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associates – Molecular Imaging Innovations

    Weill Cornell Medicine – New York, New York, United States

    Postdoctoral Research Associate – Hematopoietic Stem and Progenitor cells

    University Hospital RWTH Aachen – Aachen, Germany

    Postdoctoral Position – Perinatal Neuroscience

    University of Gothenburg – Gothenburg, Sweden

    Group Leader – Cancer Immunology

    VIB Center for Cancer Biology – Leuven, Belgium

    Associate Professor – Pediatric Blood and Marrow Transplantation

    Fred Hutchinson Cancer Center – Seattle, Washington, United States

    > See All Jobs

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