 | | Vol. 24.23 – 10 July, 2023 |
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| Investigators systematically analyzed CD19 CAR-T cells of 10 children with relapsed and refractory childhood pre-B cell acute lymphoblastic leukemia enrolled in the CARPALL trial.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists developed an engineered artificial vesicles (EAVs), ANG-TRP-PK1@EAVs, which were constructed using a liposome extruder from HEK293T cells expressing ANG-TRP-PK1 peptides.
[Advanced Materials] |
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| Researchers used a combination of atomic force microscopy, dynamic light scattering, transmission electron microscopy, cryogenic transmission electron microscopy, and the determination of the intra-LNP pH gradient to analyze the nanoparticles in BNT162b2.
[ACS Nano] |
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| The authors reported a deep-penetration functionalized cuttlefish ink nanoparticle (CINP) for photothermal and immunological therapy of wound infections. CINP was decorated with zwitterionic polymer (ZP) to form CINP@ZP nanoparticles.
[Biomaterials] |
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| Researchers developed a 2-in-1 strategy to insert EF1α-driven CD7-specific CAR at the disrupted CD7 locus and compared it to two other known strategies: one was random integration of CAR by a retrovirus and the other was site-specific integration at T cell receptor alpha constant locus.
[Leukemia] |
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| Investigators compared different PD-1-CD28 immunostimulatory fusion protein variants in a human leukemia model to assess the impact of distinctive design choices on CAR T cell performance in vitro and a xenograft mouse model.
[British Journal of Cancer] |
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| Researchers conducted a single-center, retrospective comparative study that consisted of 12 patients who were treated with donor lymphocyte infusion and 12 patients treated with donor-derived CD19 CAR-T cells with three overlaps.
[Human Cell] |
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| Investigators tested the protective efficacy of these redox nanoparticles in cell culture and a mouse model of ischemic stroke. Induced human dental pulp stem cells were subjected to oxygen–glucose deprivation and reoxygenation to recapitulate ischemia and reperfusion in the penumbra surrounding a cerebral infarct.
[Human Cell] |
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| Scientists developed and evaluated the efficacy of novel CAR-T cells targeting PTK7 through TREM1/DAP12 signaling against ovarian cancer. The expression of PTK7 in ovarian cancer tissues and cells was evaluated using immunohistochemical staining and flow cytometric analysis.
[Medical Oncology] |
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| Investigators cover the evolution of CAR-T therapy against various tumors, including hematological and solid tumors, highlights challenges faced by CAR-T cell therapy, and suggests strategies to overcome these obstacles.
[Journal of Translational Medicine] |
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| The authors provide an overview of the advances made in the understanding of the various types of stem cells and progress made in the use of these stem cells for the treatment of ischemic brain injuries.
[Translational Stroke Research] |
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| The US FDA approved Lantidra, the first allogeneic pancreatic islet cellular therapy made from deceased donor pancreatic cells for the treatment of type 1 diabetes.
[FDA] |
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| Professor John Snowden, Consultant Hematologist at Sheffield Teaching Hospitals NHS Foundation Trust and Director of the Blood and Marrow Transplant and Cellular Therapy Program in Sheffield has won a national Researcher of the Year award.
[Sheffield Teaching Hospitals NHS Foundation Trust] |
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| The UK Rare Disease Research Platform has been established with a £14 million investment over five years by the Medical Research Council and the National Institute for Health and Care Research.
[UK Research and Innovation] |
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| August 3, 2023
New York, New York, United States |
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| | Institute of Biology Valrose – Nice, France |
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| | NCI Center for Cancer Research – Bethesda, Maryland, United States |
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| | Weill Cornell Medicine – New York, New York, United States |
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| | University Hospital RWTH Aachen – Aachen, Germany |
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| | University of Gothenburg – Gothenburg, Sweden |
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Cancer Stem Cell News
Cell Therapy News
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