Cell Therapy News Volume 24.24 | Jul 17 2023

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    2023-07-17 | CTN 24.24


    Cell Therapy News by STEMCELL Technologies
    Vol. 24.24 – 17 July, 2023
    TOP STORY

    Co-Transplantation of Autologous Treg Cells in a Cell Therapy for Parkinson’s Disease

    Investigators showed that the surgical procedure itself, referred to here as ‘needle trauma’, triggered a profound host response that was characterized by acute neuroinflammation, robust infiltration of peripheral immune cells, and brain cell death.
    [Nature]

    AbstractPress Release
    PUBLICATIONSRanked by the impact factor of the journal

    Young Glial Progenitor Cells Competitively Replace Aged and Diseased Human Glia in the Adult Chimeric Mouse Brain

    Scientists engrafted wild-type human glial progenitor cells (hGPCs) produced from human embryonic stem cells into the striata of adult mice that had been neonatally chimerized with mutant Huntingtin-expressing hGPCs.
    [Nature Biotechnology]

    Full Article

    Vaccine-Boosted CAR T Crosstalk with Host Immunity to Reject Tumors with Antigen Heterogeneity

    Researchers found that in vivo vaccine boosting of CAR T cells triggers the engagement of the endogenous immune system to circumvent antigen-negative tumor escape.
    [Cell]

    Full ArticleGraphical Abstract

    Engineering Efficient CAR-T Cells via Electroactive Nanoinjection

    Scientists developed a non-viral electroactive nanoinjection platform to efficiently negotiate the plasma membrane of primary human T cells via vertically configured electroactive nanotubes, enabling efficient delivery and expression of CAR genes in the T cells.
    [Advanced Materials]

    Abstract

    mRNA Lipid Nanoparticle-Mediated Pyroptosis Sensitizes Immunologically Cold Tumors to Checkpoint Immunotherapy

    Researchers reported a single-agent mRNA nanomedicine-based strategy that utilized mRNA lipid nanoparticles encoding only the N-terminus of gasdermin to trigger pyroptosis, eliciting robust antitumor immunity.
    [Nature Communications]

    Full Article

    Transplanting FVIII/ET3-Secreting Cells in Fetal Sheep Increases FVIII Levels Long-Term without Inducing Immunity or Toxicity

    Investigators showed that prenatal transplantation of human placental cells bioengineered to produce an optimized FVIII protein, results in considerable elevation in plasma FVIII levels that persists for >three years post-treatment.
    [Nature Communications]

    Full Article

    Transplantation of Adipose Tissue-Derived Microvascular Fragments Promotes Therapy of Critical Limb Ischemia

    The authors isolated microvascular fragments, stromal vascular fractions, and mesenchymal stem cells from human lipoaspirate and studied their therapeutic efficacy and in vivo vasculogenic activity in a murine model of hindlimb ischemia.
    [Biomaterials Research]

    Full Article

    Mitochondria Transplantation Mitigates Damage in an In Vitro Model of Renal Tubular Injury and in an Ex Vivo Model of DCD Renal Transplantation

    Researchers tested whether mitochondrial transplantation, a process where exogenous isolated mitochondria are taken up by cells, mitigated damage in two models of acute kidney injury.
    [Annals of Surgery]

    Abstract

    Tumor Targeting and Therapeutic Assessments of RNA Nanoparticles Carrying α9-nAchR Aptamer and Anti-miR-21 on Triple-Negative Breast Cancers

    Scientists utilized thermodynamically stable three-way junction pRNA as the core to construct RNA nanoparticles with α9-nicotinic acetylcholine receptor (nAchR) RNA aptamer as a targeting ligand and an anti-miR21 as a therapeutic module.
    [Molecular Therapy – Nucleic Acids]

    Abstract
    Learn how to edit human liver organoids using CRISPR-Cas9 with the help of this step-by-step protocol.
    REVIEWS

    Are We Ready for Personalized CAR-T Therapy?

    The authors outline the need for an individualized approach to CAR-T therapy, present the light and shadow of currently available drugs, and try to predict the nearest perspective.
    [European Journal Of Haematology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Tenpoint Therapeutics Launches with $70 Million Series a Financing to Reverse Vision Loss through Engineered Cell-Based Therapeutics and In Vivo Reprogramming

    Tenpoint Therapeutics announced its launch with a $70 million Series A financing to develop its regenerative medicine platform to replace multiple cell types lost to inherited and age-related conditions.
    [Tenpoint Therapeutics]

    Press Release

    UB, Partner Awarded $3 Million NIH Grant to Study Immune Cell Therapy for Tumors

    The National Cancer Institute awarded Dr. Ruogang Zhao, professor of biomedical engineering at the University at Buffalo (UB), and a colleague a five-year, $3 million R01 research grant to study immune cell therapy for solid tumors.
    [University at Buffalo]

    Press Release
    FEATURED EVENT

    2023 Barrier Function of Mammalian Skin Conference GRC

    August 6 – 11, 2023
    Waterville Valley, New Hampshire, United States

    > See All Events

    JOB OPPORTUNITIES

    Group Leader – The Molecular Bases of Disease Processes

    Institute of Biology Valrose – Nice, France

    Postdoctoral Position – 3D Printing and Osteosarcoma

    Maastritch University – Maastricht, Netherlands

    Scientific Director – Clinical Research

    NCI Center for Cancer Research – Bethesda, Maryland, United States

    Postdoctoral Associates – Molecular Imaging Innovations

    Weill Cornell Medicine – New York, New York, United States

    Postdoctoral Scientist – Tumor Immunology and Radio-Immunotherapy

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    > See All Jobs

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