 | | Vol. 24.30 – 11 September, 2023 |
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| Researchers showed that a temperature-sensitive hydrogel conjugated with antibodies for the pro-inflammatory cytokine interleukin-6 (IL-6) and subcutaneously injected before the infusion of CAR-T cells substantially reduces the levels of IL-6 during CRS while maintaining the therapy’s antitumor efficacy.
[Nature Biomedical Engineering] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that the MS4A1 gene encoding human CD20 also produces several mRNA isoforms with distinct 5′ untranslated regions. Four variants were detectable by RNA-seq in distinct stages of normal B cell differentiation and B lymphoid malignancies, with V1 and V3 being the most abundant by far.
[Blood] |
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| An anti-CD40L-specific monoclonal antibody, AT-1501 (Tegoprubart), was engineered to minimize risk of thromboembolic complications by reducing binding to Fcγ receptors expressed on platelets while preserving binding to CD40L.
[Science Translational Medicine] |
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| Investigators presented a prototype -human CAR-T construct targeting nfP2X7 showing potential antigen-specific cytotoxicity against 12 solid cancer types. In xenograft mouse models of breast and prostate cancer, CAR-T cells targeting nfP2X7 exhibit robust anti-tumor efficacy.
[Nature Communications] |
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| The authors indicated that ERK1-/- BMMSCs, but not ERK2-/- bone marrow MSCs, failed to promote T cell apoptosis due to incapacity to activate the ETS2/AURKA/NFκB/Fas/MCP-1 cascade.
[iScience] |
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| In vitro experiments showed that co-culturing umbilical cord MSCs and chondrocytes promoted the expression of aggrecan, COL2, SOX9, and BCL-2; downregulated the expression of BAX and BAD in chondrocytes; and promoted the expression of IL-10 and TGF-β1 in UCMSCs.
[Scientific Reports] |
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| A Phase IB/IIA randomized control trial was performed in a 3:1, single-blinded study. Patients included were adult women with an anovaginal/rectovaginal fistula in the setting of Crohn disease.
[Surgery] |
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| A Phase IB/IIA randomized control trial was performed in a 3:1, single-blinded study. Patients included were adult women with an anovaginal/rectovaginal fistula in the setting of Crohn disease.
[Surgery] |
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| A bovine CD8 cytotoxic T lymphocyte cell line specific for an autologous target cell infected with a protozoan parasite, Theileria parva, was used to determine the efficacy of the centrifugal bioreactor for adoptive cell therapy purposes.
[Biotechnology Progress] |
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| Stem cell therapy still faces multiple challenges, such as the durability and survival of mesenchymal stem cells upon implantation, uncertain pathways to discogenic differentiation, and the adverse impact of a harsh microenvironment on cell survival.
[Biomolecules & Biomedicine] |
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| The Ohio State University Wexner Medical Center is one of the first nationwide to administer a targeted gene therapy for patients with a specific form of amyotrophic lateral sclerosis, a neurodegenerative disease that affects the cells in the brain and spine.
[Ohio State University] |
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| Researchers are marking another milestone in the long road toward making islet cell transplantation a reality for people with type 1 diabetes, which has long been pursued as a possible cure.
[Miller School of Medicine] |
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| October 1 – 4, 2023
Whistler, British Columbia, Canada |
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| | University of California, Los Angeles – Los Angeles, California, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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| | University of California – Los Angeles, California, United States |
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| | The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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