 | | Vol. 14.32 – 18 September, 2023 |
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| Investigators conducted a Phase II study, ALYCANTE, to assess the efficacy and safety of a single axi-cel infusion as a second-line therapy in patients with high-risk relapsed/refractory large B cell lymphoma deemed ineligible for autologous stem cell transplantation but eligible for CAR T cell therapy.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that in situ conjugation of polyethylene glycol to the surface of CAR T cells (‘PEGylation’) created a polymeric spacer that blocks cell-to-cell interactions between CAR T cells, tumor cells and monocytes.
[Nature Materials] |
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| The authors described a broadly applicable nongenetic approach that simultaneously addressed the multiple challenges of CAR T as a therapy for solid tumors.
[Nature Communications] |
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| The combination of cancer cell desialylation and induced pluripotent stem cell–derived chimeric antigen receptor–macrophage adoptive cellular therapy exerted a dramatic therapeutic effect on solid tumors and significantly prolonged the survival of tumor-bearing mice.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Human pluripotent stem cells were differentiated into hematopoietic progenitor cells (HPCs) and Natural Killer cells using a novel organoid system. HPC engraftment potential was assessed using NSG mice.
[Oncoimmunology] |
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| Researchers established a heat-stressed Hu sheep model during mid-late gestation and selected intrauterine growth retardation (IUGR) and normal lambs for analysis. Exosomes from umbilical plasma were separated and small RNA sequencing was used to identify differentially expressed miRNAs.
[Communications Biology] |
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| Scientists developed a one-step biomanufacturing platform that uses small-aperture gelatin microcarriers to produce beads carrying midbrain dopaminergic progenitor cells.
[Neural Regeneration Research] |
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| Investigators used the fused deposition modeling technique with the 3D printing technique to fabricate the thermoplastic polymer and composite scaffolds. MG-63 cells were injected and attached to the mesh-manufactured polycaprolactone scaffolds.
[Journal Of The Formosan Medical Association] |
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| Scientists entailed the generation and evaluation of a second-generation CAR against a carbohydrate antigen on malignant prostate cancer cells.
[Biochemical And Biophysical Research Communications] |
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| The rate of progression and breakthrough in the area of in vitro spermatogenesis is lower than that of spermatogonial stem cell transplantation, but newer methods are being developed.
[Cell And Tissue Research] |
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| | Medigene AG announced that it has selected its lead candidate for MDG2011, a T cell receptor engineered T cell (TCR-T) therapy targeting KRAS G12V with HLA-A*11 and being developed in combination with the Company’s PD1-41BB costimulatory switch protein technology.
[Medigene AG] |
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| October 1 – 4, 2023
Toronto, Ontario, Canada |
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| | ETH Zurich – Zürich, Switzerland |
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| | City of Hope – Duarte, California, United States |
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| | Imperial College London – London, England, United Kingdom |
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| | Creative Biolabs – New York, New York, United States |
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| | City of Hope – Duarte, California, United States |
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