 | | Vol. 24.33 – 23 October, 2023 |
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| Scientists identified two T cell receptors (TCRs) specific for the 9-mer KRAS-G12V mutant neoantigen in the context of HLA-A*11:01. The TCR-T cells were constructed and displayed cytokine secretion and cytotoxicity upon co-culturing with varied tumor cells expressing the KRAS-G12V mutation.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Human iPSC-cartilaginous particles wrapped with tissue engineered constructs containing human mesenchymal stem cells attained secure defect filling with good integration to adjacent tissue in a rat osteochondral injury model.
[NPJ Regenerative Medicine] |
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| Investigators described an ex vivo pleural effusion culture assay, using malignant pleural-effusion-derived soluble and cellular factors that differentially affected the cytotoxicity of CAR T cells.
[Cell Reports Methods] |
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| The microarray dataset GSE12884 was analyzed to identify the differentially expressed lncRNAs in adipose-derived mesenchymal stem cells under normoxia and hypoxia. The expression of the key genes was detected using qRT-PCR, western blot assay, and immunofluorescence staining.
[Journal Of Translational Medicine] |
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| After a comprehensive clinical characterization and cytokine profiling of patients enrolled in a Phase I clinical trial evaluating CD22 CAR T cells for B cell malignancies, investigators further analyzed samples from 10 patients with cytokine release syndrome for total IL-18, free IL-18, and IL-18BP.
[Blood Advances] |
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| The authors presented the development of a novel CAR-T cell therapy targeting B-cell activating factor receptor, a key regulator of B-cell proliferation and maturation. A new monoclonal antibody against BAFF-R was generated from a hybridoma clone and used to create a novel MC10029 CAR construct.
[Cancer Immunology Immunotherapy] |
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| Lipid nanoparticles were examined for ex vivo CAR-mRNA delivery and compared to electroporation (EP). LNP-CAR T cells showed a significantly prolonged efficacy in vitro in comparison to EP-CAR T cells as a result of extended CAR-mRNA persistence and CAR expression.
[Molecular Therapy-Methods & Clinical Development] |
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| To clarify the role of allogeneic hematopoietic stem-cell transplantation (HSCT) in the CAR T cell therapy era, researchers analyzed the clinical characteristics and outcomes of 52 patients treated with allo-HSCT with relapsed/refractory diffuse large B cell lymphoma.
[Scientific Reports] |
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| Investigators conducted a Phase Ib trial testing time-limited therapy with different immunotherapy doublets targeting 4-1BB, OX-40, and PD-L1 in combination with rituximab among patients with relapsed/refractory grade 1–3A follicular lymphoma.
[Annals Of Hematology] |
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| Recent advances in human-derived DNA-binding domains, and transcriptional activation domains paired with novel control modules responsive to clinically approved small molecules, have poised the synthetic transcription factorsF field to overcome hurdles.
[Trends In Biotechnology] |
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| Although many studies have helped to elucidate the signaling intermediates that mediate T cell activation, the molecules and pathways that keep naive T cells in check are less understood.
[Trends in Immunology] |
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| The Mass General Brigham Gene and Cell Therapy Institute conducting clinical trials and developing FDA-approved treatments, announced the six winners of its first annual Spark Grant program.
[Mass General Brigham] |
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| Patients describe a distinct before-and-after from gene therapy, but it’s less a lightning bolt than a slow dawning that begins by waking up one morning and realizing that their pain is gone.
[Bloomberg] |
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| November 26 – 29, 2023
Buxted Park, England, United Kingdom |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Berlin Institute of Health at Charit̩ РBerlin, Germany |
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| | Medical University of South Carolina – Charleston, South Carolina, United States |
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| | Technical University of Denmark – Copenhagen, Denmark |
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| | City of Hope – Duarte, California, United States |
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