 | | Vol. 24.34 – 30 October, 2023 |
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| Scientists reported dose escalation results from the ongoing phase I/II BNT211-01 trial evaluating the safety and feasibility of CAR T cells targeting the Claudin 6 (CLDN6) with or without a CAR-T cell-amplifying RNA vaccine at two dose levels in relapsed/refractory CLDN6-positive solid tumors.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors evaluated the potential interference between the CD19-targeting monoclonal antibody tafasitamab and CART19 treatment in preclinical models.
[Blood] |
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| Investigators established a method for transplanting intestinal organoids into intestinal ischemia-reperfusion (I/R) mice. They found that transplantation improved mouse survival, promoted self-renewal of intestinal stem cells, and regulated the immune microenvironment after intestinal I/R.
[Nature Communications] |
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| Researchers developed hypoxia-responsive CAR-T cells by engineering the CAR to be under regulation of hypoxia responsive elements and selected the optimal structure, which could be activated in the tumor hypoxic microenvironment to induce CAR-T cells with high polyfunctionality.
[Cancer Research] |
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| The authors proposed a novel magnetic resonance imaging contrast agent formulation by encapsulating iron oxide nanoparticles in poly(lactic–co–glycolic acid) particles functionalized with a tissue adhesive polydopamine layer.
[Journal of Controlled Release] |
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| Researchers characterized the protein composition of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) using a proteomics approach and found that mitochondrial protein superoxide dismutase 2 (SOD2) was enriched in MSC-EVs.
[Molecular Therapy – Nucleic Acids] |
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| An organoid culture model was developed to regenerate articular cartilage by sequential treatment with BMP2 and BMP9 that paralleled induced joint regeneration at digit amputation wounds in vivo.
[Development] |
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| Investigators characterized the long-term fate and safety of human dorsal spinal γ-aminobutyric acid (GABA) neural progenitor cells (NPCs) in naïve rats over one year. All grafted NPCs had undergone differentiation, yielding mainly neurons and astrocytes.
[iScience] |
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| A chimeric human/mouse model of synovitis was created by surgically implanting severe combined immunodeficiency disease mice with a piece of human articular cartilage surrounded by synovial fibroblasts.
[Arthritis Research & Therapy] |
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| As the numbers of approved products and indications continue to grow, new strategies to increase cell-manufacturing capacity are urgently needed to ensure patient access. Distributed manufacturing at the point of care or at other local manufacturing sites would go a long way toward meeting the rising demand.
[Nature Biotechnology] |
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| The authors comprehensively analyze the engineering methods utilized for modifying donor cells and extracellular vesicles, with a focus on comparing the therapeutic potential between engineered and natural extracellular vesicles.
[iScience] |
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| At a recent BioAlberta event in Edmonton, the Alberta Cancer Foundation announced a major boost for the province’s cellular therapy program – a revolutionary treatment for cancer that has the potential to dramatically improve survival rates for hard-to-treat cancers.
[Financial Post] |
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| A nearly year-long clinical hold on Verve Therapeutics’ base editing therapy meant to treat a genetic form of high cholesterol has been lifted in the US, thanks to data from an ongoing human trial elsewhere in the world and some preclinical work that has allayed the FDA’s concerns.
[FierceBiotech] |
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| November 18 – 19, 2023
Montréal, Québec, Canada |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Turku – Turku, Finland |
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| | King’s College London – London, England, United Kingdom |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Notre Dame – Notre Dame, Indiana, United States |
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