 | | Vol. 24.35 – 6 November, 2023 |
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| Scientists developed a ceria nanoparticle-immobilized mesenchymal stem cell nanovesicle hybrid system to address multiple factors in rheumatoid arthritis.
[Nature Nanotechnology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators systematically engineered new CD3 CARs, each containing only one of the CD3 intracellular domains. CARs containing CD3δ, CD3ε, or CD3γ cytoplasmic tails outperformed the conventional ζ CAR T cells in vivo.
[Nature Immunology] |
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| Researchers determined whether competition with mouse satellite cells (SCs) prevented skeletal muscle progenitor cell engraftment into the SC niche and thus generated an SC ablation mouse compatible with human engraftment.
[Nature Cell Biology] |
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| Scientists demonstrated that long-term cryopreserved cord blood retained similar numbers of hematopoietic stem and progenitor cells compared with fresh and recently cryopreserved cord blood units.
[Cell Reports Medicine] |
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| Researchers successfully engineered CD4+ T cells into Foxp3-T cells that transiently exhibited an immunosuppressive phenotype and functionally suppressed the proliferation of effector T cells
[Nano Letters] |
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| The authors evaluated the anti-fibrotic properties of extracellular vesicles (EVs) derived from human induced pluripotent stem cells (hiPSCs) that were cultured under various oxygen concentrations.
[BMC Medicine] |
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| Investigators determined whether the engraftment of old organs could induce senescence in younger recipients,thus promoting age-related pathologies.
[American Journal Of Transplantation] |
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| Scientists performed pancreatic progenitor differentiation with and without AKT/P70 inhibitor AT7867 and characterized the resulting cells at protein and transcript level in vitro and in vivo upon transplantation into diabetic mice.
[Stem Cell Reports] |
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| Researchers developed a surgery-induced tumor metastasis model in immunocompetent mice to investigate the efficacy of CAR-T cell therapy in preventing metastasis and local recurrence.
[Human Gene Therapy] |
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| The author re-evaluates current data and suggests potential pathways towards greater success, drawing lessons from the few successful trials testing CAR T cells in patients with solid tumors and the clinical experience with tumor-infiltrating lymphocytes.
[Nature Reviews Clinical Oncology] |
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| Scientists highlight recent advancements in smart nanoparticles, including polymeric nanoparticles, dendrimers, micelles, liposomes, protein nanoparticles, cell membrane nanoparticles, and more.
[Signal Transduction and Targeted Therapy] |
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| Kyverna Therapeutics announced the signing of a multi-year research funding agreement with Charité to investigate the impact of B- and plasma cell-targeting therapies – including CAR T cells – on the immunologic profile and clinical outcomes of patients with systemic autoimmune diseases.
[Kyverna Therapeutics] |
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| November 28 – 30, 2023
San Francisco, California, United States |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Turku – Turku, Finland |
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| | Cedars-Sinai – Los Angeles, California, United States |
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