 | | Vol. 24.36 – 20 November, 2023 |
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| Researchers investigated the influence of the tumor immune microenvironment and CAR design on the anti-glioma activity of B7-H3-specific CAR T cells.
[Cancer Research Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that the genetic disruption of SUV39H1, which encodes a histone-3, lysine-9 methyl-transferase, enhanced the early expansion, long-term persistence, and overall anti-tumor efficacy of human CAR T cells in leukemia and prostate cancer models.
[Cancer Discovery] |
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| An injectable supramolecular hydrogel system has been designed to load plasmid CAR with T cell specific CD2 promoter, which successfully achieved in situ fabrication and effective accumulation of CAR-T cells at the tumor site in humanized mice models.
[Advanced Materials] |
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| Studies revealed that six-transmembrane epithelial antigen of prostate-2 (STEAP2) was a prevalent prostate cancer antigen that displayed high, homogeneous cell surface expression across all stages of disease with limited distal normal tissue expression.
[Journal Of Clinical Investigation] |
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| The authors provided compelling evidence demonstrating the indispensable role of epithelial miRNAs in the regeneration of the intestine in mice subjected to 5-FU or irradiation-induced injury.
[ACS Nano] |
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| Scientists modified mRNA-lipid nanoparticles with the fusogenic coiled-coil peptides and demonstrated efficient mRNA delivery to difficult-to-transfect induced pluripotent stem-cell-derived cardiomyocytes.
[ACS Nano] |
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| The authors developed CAR T cells against multiple myeloma using a binder to targeting transmembrane activator and CAML interactor in mono and dual-specific formats with anti-B cell maturation antigen (BCMA).
[Nature Communications] |
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| Scientists identified paired box 6 (PAX6) as a critical regulator of beta cell survival. The human beta cell line EndoC-βH1, db/db mouse, and human islets displayed dampened insulin and incretin signalings and reduced beta cell survival, which were alleviated by PAX6 overexpression.
[EMBO Molecular Medicine] |
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| Investigators evaluated hematopoietic stem cell transplantation (HSCT), intravenous (IV) AAVrh10 gene therapy, and combination HSCT + IV AAVrh10 in the canine model of globoid cell leukodystrophy.
[Molecular Therapy] |
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| The authors focus on linking the efficacy and safety of CAR T cell therapy with tumor burden. Emerging clinical approaches to overcome these obstacles and more effectively incorporate this therapeutic strategy into the treatment paradigm of patients with solid malignant tumors are also described.
[JAMA Oncology] |
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| Professor Gail Risbridger and her research team from Monash University will receive $5 million in funding over 5 years for research to advance immunotherapy treatments for treating prostate cancer.
[NHMRC] |
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| In a world first, the UK medicines regulator has approved a therapy that uses the CRISPR–Cas9 gene-editing tool as a treatment. The approval by the Medicines and Healthcare Products Regulatory Agency (MHRA) follows promising results from clinical trials that tested a one-time treatment.
[Nature] |
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| December 2 – 6, 2023
Boston, Massachusetts, United States |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | German Cancer Research Center in the Helmholtz Association – Heideland, Germany |
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| | Chinese Academy of Sciences – Shenzhen, China |
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| | Masaryk University – Brno, Czech Republic |
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| | Armenian Bioinformatics Institute – Yerevan, Armenia |
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