 | | Vol. 24.37 – 27 November, 2023 |
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| Researchers conducting a Phase I/II, open-label, multicenter trial aimed at optimizing cell engraftment and reported interim, one-year outcomes in one study group that received two–threefold higher cell doses in devices with an optimized membrane perforation pattern.
[Nature Biotechnology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that the overexpression of eight immunomodulatory transgenes in mouse ESCs was sufficient to immunologically ‘cloak’ the cells as well as tissues derived from them, allowing their survival for months in outbred and allogeneic inbred recipients.
[Nature Biomedical Engineering] |
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| Scientists conducted a single-cell multi-omics analysis of transcriptional, clonal, and phenotypic profiles from pre- to one-month post-infusion of CAR+ and CAR− T cells from patients from a CARTELL study who received a donor-derived 4-1BB CAR product targeting CD19.
[Nature Communications] |
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| The authors undertook translational studies in human and mouse orthotopic liver transplantation to interrogate the significance of hepatocyte-specific Sirtuin 1 (SIRT1) in cold-stored donor livers and liver grafts after reperfusion.
[Cell Death & Disease] |
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| Researchers developed bifunctional fusion “degrader” proteins that bridge one or more target proteins and an E3 ligase complex to enforce target ubiquitination and degradation.
[Cell Chemical Biology] |
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| Investigators demonstrated that the application of autologous bone marrow mononuclear cells was well tolerated, and bone healing could be achieved.
[Stem Cells Translational Medicine] |
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| Scientists demonstrated that human CD33/CD123 bispecific CAR T cells were a promising cell-based approach to prevent acute myeloid leukemia and support clinical investigation.
[Molecular Therapy Oncolytics] |
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| Results indicated that CEA Cell Adhesion Molecule 5 (CEACAM5) was a marker that enriched functional human hematopoietic stem cells capable of long-term multi-lineage engraftment.
[iScience] |
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| Induced pluripotent stem cell (iPSC)-derived A2B5+ oligodendrocyte precursor cells were obtained from mouse embryonic fibroblasts and injected into the lesion sites of spinal cord contusion rats.
[Heliyon] |
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| The authors comprehensively evaluate the current state of methods for tracking stem cells, highlighting their strengths and weaknesses, and providing insights into their future potential.
[Stem Cell Reviews And Reports] |
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| Scientists review the ongoing developments with CAR T cells in the field of autoimmune disorders and further address safety and manufacturing aspects for CAR T cells including mRNA technologies and automation concepts for ensuring the future availability of safe and efficient CAR T cell products.
[RMD Open] |
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| Two researchers at the University of California (UC) San Diego received close to $10 million in grants from the California Institute of Regenerative Medicine, the agency announced.
[UC San Diego] |
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| December 16 – 20, 2023
Waikoloa Beach, Hawaii, United States |
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| | Oslo University Hospital – Oslo, Norway |
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| | Weill Cornell Medicine – New York City, New York, United States |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | Armenian Bioinformatics Institute – Yerevan, Armenia |
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| | Chinese Academy of Sciences – Shenzhen, China |
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Cancer Stem Cell News
Cell Therapy News
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Intestinal Cell News
Mammary Cell News
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