 | | Vol. 24.38 – 4 December, 2023 |
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| Investigators showed that replacement of the extracellular domains of heterodimeric cytokine receptors in T cells with two leucine zipper motifs provided optimal Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling.
[Nature Biomedical Engineering] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors presented the clinicogenomic characterization of a CARTITUDE-4 patient who developed a CAR+ T cell lymphoma post cilta-cel. Diagnostic and staging workup included biopsy analyses and FDG-PET scan.
[blood] |
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| Scientists reported the analysis of one year of data from the first cohort of 15 patients enrolled in an open-label, first-in-human, dose-escalation Phase I study to determine the feasibility, safety, and tolerability of the transplantation of allogeneic neural stem cells for the treatment of secondary progressive multiple sclerosis.
[Cell Stem Cell] |
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| Researchers demonstrated that EpCAM–CAR-T cells costimulated by Dectin-1 exhibited robust antitumor activity without adverse effects in xenograft mouse models and EpCAM-humanized mice.
[Science Advances] |
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| Scientists described an approach using platelet-optimized lipid nanoparticles containing mRNA to enable exogenous protein expression in human and rat platelets.
[Science Advances] |
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| Researchers presented a protocol that enabled efficient generation, expansion, and biobanking of pediatric brain cancer organoids.
[EMBO Molecular Medicine] |
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| Investigators performed targeted DNA sequencing of 457 hematopoietic stem cell grafts collected for autologous stem cell transplantation in myeloma patients and correlated their findings with high-dimensional longitudinal clinical and laboratory data.
[Haematologica] |
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| Researchers identified cathepsin E (Ctse) as the most differentially expressed gene between CD8+ T cells of B6 and B6.SJL and demonstrated that the differences reported between these two mouse strains were not due to CTSE.
[Lab Animal] |
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| Investigators demonstrated that invariant NKT (iNKT) cells could be efficiently expanded using modified cytokines combination from peripheral blood mononuclear cells.
[iScience] |
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| The authors provide an overview of current preclinical approaches in that lipid nanoparticle surface modification was leveraged for cell and tissue targeting by conjugating aptamers, antibodies, and peptides among others.
[The Journal of Gene Medicine] |
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| The FDA has received reports of T cell malignancies, including chimeric antigen receptor CAR-positive lymphoma, in patients who received treatment with BCMA- or CD19-directed autologous CAR T cell immunotherapies.
[FDA] |
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| January 16 – 19, 2024
San Diego, California, United States & Virtual |
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| | Albert-Ludwigs-University Freiburg – Freiburg im Breisgau, Germany |
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| | Oslo University Hospital – Oslo, Norway |
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| | Weill Cornell Medicine – New York City, New York, United States |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | Armenian Bioinformatics Institute – Yerevan, Armenia |
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