 | | Vol. 24.39 – 11 December, 2023 |
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| The authors performed allogeneic induced pluripotent stem cell-derived retinal organoid sheet transplantation in two subjects with advanced retinitis pigmentosa.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers designed a Y-shaped DNA nanostructure to deliver microRNA-122, which could induce the hepatic differentiation and maturation of human mesenchymal stem cells.
[ACS Nano ] |
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| To investigate leukemia-intrinsic CAR-T resistance mechanisms, scientists performed genome-wide CRISPR-Cas9 loss-of-function screens in an immunocompetent murine model of B cell acute lymphoblastic leukemia utilizing a modular guide RNA library.
[Nature Communications] |
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| Investigators developed an in vivo CAR T cell engineering platform to streamline production while using mRNA to induce transient, tunable CAR expression.
[Small] |
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| Researchers evaluated the in vivo safety and distribution of Klotho-enhanced urine-derived stem cells after intravenous administration in accordance with Good Laboratory Practice regulations.
[Stem Cell Research & Therapy] |
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| Scientists compared human umbilical cord-mesenchymal stem cell (hUC-MSC) in vivo engraftment efficacy and cytokine expression for both hUC-MSC sheets and cell suspensions.
[Stem Cell Research & Therapy] |
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| Investigators reported that plasmid encoding a trimeric spike protein with lipid nanoparticle delivery (pTS/LNP), similar to those in Moderna’s COVID-19 vaccine, induced more effective humoral responses than naked pTS or pTS delivered via electroporation.
[Molecular Therapy-Methods & Clinical Development] |
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| A novel strategy was demonstrated, that utilized the xenogeneic, decellularized goat small intestine as a patch for small intestine regeneration in cases of intestinal perforation.
[Tissue Barriers] |
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| Scientists investigated the therapeutic efficacy and evidence of cell migration of adipose-derived stem cells injected into the pericardial cavity in rat heart failure.
[ESC Heart Failure] |
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| Investigators outline the principles of CAR-T therapy and then highlight its limitations in the context of solid tumors. They focus on preclinical and clinical findings achieved in CAR-T-mediated targeting of different ovarian cancer-associated target antigens.
[Frontiers In Immunology] |
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| Bristol-Myers Squibb K.K. announced that the company has received manufacturing and marketing approval of the supplemental New Drug Application for an additional indication for Abecma®, a B cell maturation antigen-directed CAR T cell immunotherapy.
[Bristol-Myers Squibb K.K.] |
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| Three physician-scientists who have relocated to Buffalo, New York, to join Roswell Park Comprehensive Cancer Center will apply highly specialized transplantation and cell therapy expertise to both patient care and the development of New York State’s first cell therapy manufacturing and research hub.
[Roswell Park] |
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| January 22 – 25, 2024
Santa Fe, New Mexico, United States |
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| | International Iberian Nanotechnology Laboratory – Braga, Portugal |
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| | Cedars-Sinai Board – Anaheim, California, United States |
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| | Albert-Ludwigs-University Freiburg – Freiburg im Breisgau, Germany |
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| | Oslo University Hospital – Oslo, Norway |
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| | Weill Cornell Medicine – New York City, New York, United States |
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