 | | Vol. 25.01 – 13 January, 2024 |
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| Researchers designed FCRL5-directed CAR-T cells and assessed their cytotoxicity in vitro using a co-culture system and in vivo using multiple myeloma (MM) cell-derived xenograft models, specifically focusing on MM with gain of chromosome 1q21.
[Signal Transduction And Targeted Therapy] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators conducted a phase I trial of CAR T-EGFRvIII cells administered concomitantly with the anti-PD1 monoclonal antibody pembrolizumab in patients with newly diagnosed, EGFRvIII+ glioblastoma.
[Nature Cancer] |
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| To achieve eradication of solid tumors, the authors examined how many neoantigens need to be targeted with how many TCRs by which type of T cells. Unmanipulated, naturally expressed neoantigens were targeted with adoptively transferred TCR-engineered autologous T cells.
[Clinical Cancer Research] |
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| Scientists demonstrated, for the first time, that TNNT2-4Fpolycistronic-NIL gene therapy induced cardiomyocyte cell cycle re-entry in chronic ischemic heart failure and improved left ventricular function and that this salubrious effect was sustained for at least four months.
[Cardiovascular Research] |
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| Researchers performed a comprehensive flow cytometry analysis of 27 relapsed/refractory multiple myeloma patients treated with Idecabtagene vicleucel to assess the expansion capacity, persistence and effects on bystander cells of B cell maturation antigen-targeting CAR T cells.
[Leukemia] |
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| Investigators used RNA sequencing to assess whether the recently invented membrane-anchored and tumor-targeted IL-12-armed T cells, which bind cell-surface vimentin on tumor cells, could destroy cancer-associated fibroblasts to disrupt the extracellular matrix.
[Journal For Immunotherapy Of Cancer] |
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| The authors compared various nanoparticle coatings to enhance surface engineering for more effective nanomedicines.
[ACS Applied Materials & Interfaces] |
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| Scientists analyzed outcomes of 378 patients undergoing first llogeneic haematopoietic cell transplantation between 2006–2017 for t-MN arising secondary to lymphoma treatment.
[Bone Marrow Transplantation] |
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| Researchers investigated the potential of carbon-ion radiotherapy and isoeffective doses of X-ray radiotherapy to mediate tumor growth inhibition and survival in murine colon adenocarcinoma models in conjunction with neoantigen-specific liposome-formulated mRNA vaccines.
[Radiation Oncology] |
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| Compared to stem cells, stem cell-derived exosomes possess numerous advantages, such as non-immunogenicity, non-infusion toxicity, easy access, effortless preservation, and freedom from tumorigenic potential and ethical issues.
[Signal Transduction And Targeted Therapy] |
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| Investigators provide a forward-looking perspective on the field of RNA medical products and the potential long-term innovations and policy shifts enabled by this revolutionary and game-changing technological platform.
[NPJ Genomic Medicine] |
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| Goldman Sachs Asset Management has wrapped up fundraising for the first fund in its Life Sciences investment venture, securing $650 million in equity commitments.
[BiopharmaDive] |
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| February 21 – 24, 2024
San Antonio, Texas, United States |
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| | Roche – Penzberg, Germany |
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| | Sanofi – Cambridge, Massachusetts, United States |
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| | H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| | Michigan State University – East Lansing, Michigan, United States |
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| | Cedars-Sinai Board – Anaheim, California, United States |
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