 | | Vol. 25.02 – 22 January, 2024 |
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| The authors presented a prespecified exploratory analysis examining the association between pretreatment tumor characteristics and the efficacy of axi-cel versus standard of care.
[Nature Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators conducted a Phase I/II trial of cord blood-derived natural killer cells expressing anti-CD19 chimeric antigen receptor and interleukin-15 in 37 patients with CD19+ B cell malignancies.
[Nature Medicine] |
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| Researchers assessed the efficacy and safety of MultiStem when administered within 18 to 36 hours of ischemic stroke onset via the Treatment Evaluation of Acute Stroke Using Regenerative Cells (TREASURE) multicenter, double-blind, parallel-group, placebo-controlled Phase II/III randomized clinical trial.
[JAMA Neurology] |
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| Investigators established a cocktail of tissue-specific DNA methylation markers and used it to determine the concentration of circulating cell-free DNA molecules derived from the liver, skin, lungs, colon, and specific immune cells in 101 patients undergoing hematopoietic stem cell transplantation.
[Journal Of Clinical Investigation] |
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| Researchers investigated the potential of bone marrow-derived MSCs modified with X inactive specific transcript (XIST) lentiviral vector to modulate macrophage polarization and affect neural stem cell microenvironment reconstruction following spinal cord injury.
[Journal Of Tissue Engineering] |
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| Investigators conducted a thorough examination of essential stability attributes including vector titer, transduction efficiency, and potency for a series of clinical grade vector lots, each assessed at a minimum of 36 months following their date of manufacture.
[Molecular Therapy-Methods & Clinical Development] |
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| Scientists explored the potential role of adipose-derived stem cells and the potential mechanism associated with neutrophil extracellular traps in relieving acne vulgaris.
[Scientific Reports] |
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| By transplanting midbrain organoid cells into the striatum region of a 6-hydroxydopamine-lesioned Parkinson’s disease mouse model, researchers found that the transplanted cells survived and highly efficiently differentiated into dopaminergic neurons.
[Heliyon] |
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| Scientists evaluated the immunomodulatory effects of Good Manufacturing Practice (GMP)-compliant clinical grade MSCs obtained from four different sources on allogeneic peripheral blood mononuclear cells.
[Heliyon] |
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| Compared to stem cells, stem cell-derived exosomes possess numerous advantages, such as non-immunogenicity, non-infusion toxicity, easy access, effortless preservation, and freedom from tumorigenic potential and ethical issues.
[Signal Transduction And Targeted Therapy] |
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| Investigators discuss the major process parameters of autologous CAR-T cell manufacturing, as well as regulatory considerations and ongoing developments that will enable the next generation of CAR-T cell therapies.
[Journal Of Experimental Medicine] |
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| The authors provide an updated understanding of NK cell development, functions, and their applications in disease therapy. They explored the rationale for utilizing engineered NK cell therapies, such as CAR-NK cells, and discuss the differences between CAR-T and CAR-NK cells.
[Cell Death & Disease] |
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| The US Environmental Protection Agency (EPA) has abandoned a controversial plan to phase out all use of mammals to test the safety of chemicals by 2035.
[Science Insider] |
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| The Biomaterials Global Impact Award recognizes distinguished research and development accomplishments in the field of biomaterials. This year, the award will be shared by Professor Antonios Mikos of Rice University, and Dr. Ali Khademhosseini of Terasaki Institute for Biomedical Innovation.
[Biomaterials] |
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| February 23 – 26, 2024
Washington, DC, United States |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Albert-Ludwigs-University Freiburg – Freiburg im Breisgau, Germany |
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| | University of Alberta – Edmonton, Alberta, Canada |
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| | Roche – Penzberg, Germany |
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| | H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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