 | | Vol. 25.03 – 29 January, 2024 |
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| Scientists demonstrated that the assembled RNA-OG-peptide nanovaccines induced dendritic cell maturation, reduced tumor-mediated immunosuppression, and mobilized tumor-specific CD8+ T cell responses at the tumor site.
[ACS Nano] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors conceived a series of lipid nanoparticles to reprogram adipose stem cells with durable protein secretion capacity for enhanced tissue engineering and regeneration.
[Nature Communications] |
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| Researchers showed that urokinase plasminogen activator receptor-positive senescent cells accumulated during aging and that they could be safely targeted with senolytic CAR T cells.
[Nature Aging] |
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| Investigators developed functional 3D spheroids using mesenchymal stem cells with 2D hetero-nanostructures composed of single-stranded DNA binding carbon nanotubes and gelatin-bind black phosphorus nanosheets.
[Advanced Healthcare Materials] |
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| Scientists explored the feasibility of non-invasively monitoring intracavernous injection of adipose tissue-derived stem cells in rat and miniature pig corpus cavernosum using in vivo magnetic resonance imaging.
[Scientific Reports] |
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| Scientists examined the effect of residual bacteria on the outcome of pulp regeneration in mature teeth with apical periodontitis in dogs.
[Current Stem Cell Research & Therapy] |
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| Researchers developed an implantable device that could be prevascularized to enable vascularization of tissues in small rodents, and tested its application on the vascularization of embryonic kidneys.
[Tissue Engineering Part C-Methods] |
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| αβT/B-depleted peripheral blood stem cells were infused following conditioning consisting of fludarabine, cyclophosphamide, anti-thymocyte globulin, rituximab, and thoraco-abdominal irradiation.
[Hematology] |
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| The authors discuss concerns, specifically how cell tropism and tissue distribution of mRNA and lipid nanoparticles can lead to toxicity, and their possible reactogenicity.
[Nature Reviews Drug Discovery] |
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| Agents designed to engage the antitumour activities of other immune cells, including natural killer cells and myeloid cells, are showing promise and have the potential to treat a broader range of cancers.
[Nature Reviews Immunology] |
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| Investigators highlight emerging classes of RNA-based technologies that hold potential for osteoarthritis therapies, including small interfering RNA for gene silencing, microRNA and anti-microRNA for multi-gene regulation, mRNA for gene supplementation, and RNA-guided gene-editing platforms.
[Nature Reviews Rheumatology] |
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| Bristol Myers Squibb announced the Committee for Medicinal Products for Human Use (CHMP) has recommended marketing authorization approval of Abecma® for the treatment of adult patients with relapsed and refractory multiple myeloma who have received at least two prior therapies.
[Bristol Myers Squibb] |
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| The US FDA has issued a new warning about the possible risk of secondary cancers in cancer patients who have been treated with a form of immunotherapy called chimeric antigen receptor T-cell, or CAR-T cell, therapy.
[CNN] |
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| March 3 – 8, 2023
Ventura, California, United States |
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| | Cellistic – Mont-Saint-Guibert, Belgium |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Albert-Ludwigs-University Freiburg – Freiburg im Breisgau, Germany |
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| | University of Alberta – Edmonton, Alberta, Canada |
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| | Roche – Penzberg, Germany |
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