Cell Therapy News Volume 25.04 | Feb 5 2024

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    2024-02-05 | CTN 25.04


    Cell Therapy News by STEMCELL Technologies
    Vol. 25.04 – 5 February, 2024
    TOP STORY

    T Cell Lymphoma and Secondary Primary Malignancy Risk after Commercial CAR T Cell Therapy

    The T cell lymphoma (TCL) was diagnosed from a thoracic lymph node upon surgery for lung cancer. The TCL exhibited CD8+ cytotoxic phenotype and a JAK3 variant, while the CAR transgene was very low.
    [Nature Medicine]

    Abstract
    Gentle human T cell activation with ImmunoCultâ„¢
    PUBLICATIONSRanked by the impact factor of the journal

    Regulatory T Cells Suppress Myeloma-Specific Immunity during Autologous Stem Cell Mobilization and Transplantation

    Researchers demonstrated that patient mobilized stem cell grafts included high numbers of both effector CD8 T cells and immunosuppressive regulatory T cells.
    [Blood]

    Abstract

    Inhibition of CD38 Enzymatic Activity Enhances CAR-T Cell Immune-Therapeutic Efficacy by Repressing Glycolytic Metabolism

    By performing single-cell multi-omics data analysis on patient-derived CAR-T cells, scientists identified CD38 as a potential hallmark of exhausted CAR-T cells, which was positively correlated with exhaustion-related transcription factors and further confirmed with in vitro exhaustion models.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Efficacy and Safety of Autologous Tumor-Infiltrating Lymphocytes in Recurrent or Refractory Ovarian Cancer, Colorectal Cancer, and Pancreatic Ductal Adenocarcinoma

    Patients with treatment-refractory metastatic colorectal, pancreatic and ovarian cancers were eligible. Lymphodepleting chemotherapy was followed by infusion of ex vivo expanded tumor-infiltrating lymphocyte, manufactured at MD Anderson Cancer Center with IL-2 and agonistic stimulation of CD3 and 4-1BB.
    [Journal For Immunotherapy Of Cancer]

    Full Article

    Backbone Cationized Highly Branched Poly(β-Amino Ester)s as Enhanced Delivery Vectors in Non-Viral Gene Therapy

    By carefully adjusting the type, proportion, and backbone distribution of the added cationic groups, a series of highly effective highly branched poly(β-amino ester) gene delivery vectors were successfully constructed for cystic fibrosis disease gene therapy.
    [Journal Of Controlled Release]

    Full Article

    Engineering Dual-Responsive Prodrug-MOFs as Immunogenic Cell Death Initiator for Enhancing Cancer Immunotherapy

    A phosphate and hydrogen peroxide dual-responsive nanoplatform was reported, which was constructed by encapsulating disulfiram prodrug and modifying hyaluronic acid on copper doping metal–organic frameworks.
    [Advanced Healthcare Materials]

    Abstract

    Cell-Intrinsic PD-L1 Ablation Sustains Effector CD8+ T Cell Responses and Promotes Antitumor T Cell Therapy

    Programmed cell death protein 1 (PD-L1) ablation promoted antitumor immune responses and the maintenance of an effector-like state of therapeutic CD8+ T cells, while blockade of surface PD-L1 was unable to impact on their expansion and function.
    [Cell Reports]

    Full Article

    Dual Chimeric Antigen Receptor T Cells Targeting CD38 and SLAMF7 with Independent Signallng Demonstrate Preclinical Efficacy and Safety in Multiple Myeloma

    Investigators used CRISPR/Cas9 deletion of the CD38 gene in T cells and developed DCAR, a double CAR system targeting CD38 and CS1 through activation and co-stimulation receptors, respectively.
    [Cancer Immunology Immunotherapy]

    Abstract

    Machine Learning Combined with Single-Cell Analysis Reveals Predictive Capacity and Immunotherapy Response of T Cell Exhaustion-Associated lncRNAs in Uterine Corpus Endometrial Carcinoma

    Using transcriptome and single-cell sequencing data from The Cancer Genome Atlas and Gene Expression Omnibus databases, investigators employed co-expression analysis and univariate Cox regression to identify prognostic-associated lncRNAs associated with T cell exhaustion.
    [Cellular Signalling]

    Abstract
    Request a free wallchart on the roles of exosomes in the therapeutic effects imparted by mesenchymal stromal cells.
    REVIEWS

    Roles of Exosomes in Immunotherapy for Solid Cancers

    Scientists review the composition and sources of exosomes in the solid cancer immune microenvironment and further elaborate on the potential mechanisms and pathways by which exosomes influence immunotherapy for solid cancers.
    [Cell Death & Disease]

    Full Article

    Progress in Cardiac Tissue Engineering and Regeneration: Implications of Gelatin-Based Hybrid Scaffolds

    The authors review state-of-the-art gelatin/GelMA-based hybrid scaffolds currently applied for cardiac tissue engineering and regenerative therapy.
    [International Journal Of Biological Macromolecules]

    Abstract
    INDUSTRY AND POLICY NEWS

    Texas Medicaid Agrees to Fully Cover Gene Therapy for Afghan Refugees’ Infant

    After a months-long fight with Texas Medicaid over coverage of a gene therapy, Afghan refugees now have a chance to save their infant son. After initially balking, Texas officials have agreed to pay for the costly treatment, the boy’s family and his doctor told STAT.
    [STAT Newas]

    Editorial

    University of Florida Researchers Unlock New Frontiers in Brain Tumor Treatments

    As a physician-scientist and cancer researcher at the University of Florida, Dr. Duane Mitchell, is providing hope for patients in an area where there is often little: treatment for malignant brain tumors.
    [University of Florida]

    Press Release
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    JOB OPPORTUNITIES

    Regulatory Coordinator – Breast Oncology

    Dana-Farber – Boston, Massachusetts, United States

    Postdoctoral Associate – Cell & Molecular Biology

    The Jackson Lab – Farmington, Connecticut. United States

    Senior Process Engineer – CAR T Cells

    Cellistic – Mont-Saint-Guibert, Belgium

    Postdoctoral Scientists – New Immune Checkpoints and Immunotherapies

    Albert Einstein College of Medicine – New York, New York, United States

    Assistant Professor – Stem Cell Biology in Rare Diseases

    University of Alberta – Edmonton, Alberta, Canada

    > See All Jobs

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