 | | Vol. 25.05 – 12 February, 2024 |
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| Scientists systematically screened the effects of 71 mutations from T cell neoplasms on T cell signalling, cytokine production and in vivo persistence in tumors.
[Fractals-Complex Geometry Patterns And Scaling In Nature And Society] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | Researchers showed that the hMSCs encapsulated in the dynamic hydrogels exhibited increased TCA cycle activity, oxidative phosphorylation, and ATP biosynthesis via an E-cadherin- and AMPK-dependent mechanism.
[Advanced Materials] |
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| Investigators reported that allogeneic transplantation of genetically engineered, primary, hypoimmune, pseudo-islets resulted in their engraftment into a fully immunocompetent, diabetic non-human primate wherein they provided stable endocrine function.
[Cell Stem Cell] |
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| Researchers identified Tyrosinase Related Protein 1 as a CAR-T cell therapy target to treat patients with cutaneous and rare melanoma subtypes unresponsive to immune checkpoint blockade.
[Nature Communications] |
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| Scientists developed up to clinical readiness a new Hematopoietic Stem Cell (HSC) gene therapy approach for Mucopolysaccharidosis type II that benefitted from a novel highly effective transduction protocol.
[Molecular Therapy] |
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| Albumin-conjugated FLT3L (Alb-FLT3L) was generated and used to treat naïve C57BL/6 and OT1 mice for CD8 T cell response analysis. Syngeneic B16ova and E.G7ova mouse models were employed for adoptive cell transfer to evaluate the effects of Alb-FLT3L preconditioning of CD8 T cells on tumor progression.
[Journal Of Biomedical Science] |
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| The authors developed a cell membrane-targeting photosensitizer, TBzT-CNQi, which could generate 1O2, •OH, and O2•− via type I/II process to induce a high level of lipid peroxide for potent ferroptosis and photodynamic therapy.
[Advanced Healthcare Materials] |
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| Researchers found that a knock-in mouse with a missense S1P lyase (SPL) mutation mimicking human disease resulted in reduced SPL activity, increased S1P, increased TGF-β signaling, increased lung fibrosis, and higher mortality after injury compared to wild type.
[Journal Of Pathology] |
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| The effect of CSCs on CAR-T cell therapy was determined using in vitro and in vivo assays. Subsequently, Interleukin-24 (IL-24) was expressed along with CAR in T cells.
[British Journal Of Cancer] |
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| Scientists present an overview of the current developments of the 4D printing technology for tissue engineering and regenerative medicine, with a focus on approaches to achieve temporal changes of the shape of the printed constructs that would enable biofabrication of highly complex structures.
[Biofabrication] |
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| Despite recent advances in frontline therapy for diffuse large B-cell lymphoma (DLBCL), at least a third of those diagnosed still will require second or further lines for relapsed or refractory disease.
[Blood Cancer Journal] |
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| Following a slew of cell therapy biotech team-ups, AstraZeneca is taking manufacturing into its own hands. The British pharma announced it will plug $300 million into a new facility in Rockville, Maryland, to launch its cell therapy platforms in the US for cancer trials and future commercial supply.
[FiercePharma] |
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| The Calibr-Skaggs Institute for Innovative Medicines, the nonprofit drug development division of Scripps Research, announced that AbbVie has expanded its collaboration to further explore Calibr-Skaggs’ switchable CAR-T platform in solid tumor indications and autoimmune diseases.
[Scripps Research] |
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| March 13 – 15, 2024
Erlangen, Germany |
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Medical Technologist – Clinical Cell Therapy Lab | | BC Provincial Health Services Authority – Vancouver, British Columbia, Canada/p> |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Dana-Farber – Boston, Massachusetts, United States |
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| | The Jackson Lab – Farmington, Connecticut. United States |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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