 | | Vol. 25.06 – 26 February, 2024 |
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| The authors developed multiplexed effector guide arrays, a platform for programmable and scalable regulation of the T cell transcriptome using the RNA-guided, RNA-targeting activity of CRISPR-Cas13d.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists explored the impact of protein corona on extracellular vesicles (EVs) derived from two culturing conditions in which specific proteins acquired from media were simultaneously adsorbed on the EV surface.
[Nature Nanotechnology] |
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| Investigators enhanced CAR-T cell potency by knocking out CD39, CD73, or adenosine receptor 2a but observed only modest effects. In contrast, overexpression of adenosine (Ado) deaminase, which metabolized Ado to inosine (INO), induced stemness and enhanced CAR-T functionality.
[Cancer Cell] |
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| Researchers undertook a comprehensive preclinical study comparing the therapeutic potential of T cells either expressing second-generation anti-B cell maturation antigen (BCMA) CARs or secreting BCMAxCD3 T cell engagers in a T cell–limiting experimental setting.
[Science Translational Medicine] |
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| The authors demonstrated specificity redirection by rational design using structure-guided computational biology to generate a TRBC2-specific antibody.
[Nature Communications] |
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| The authors showed that CAR T-cells engaging TP53-deficient leukemia cells exhibited a prolonged interaction time, upregulated exhaustion markers, and were inefficient to control acute myeloid leukemia (AML) cell outgrowth in vitro and in vivo compared to TP53 wild-type cells.
[EMBO Molecular Medicine] |
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| Researchers employed a well-established reporter cell system to demonstrate high potency of inhibitory signaling domain CAR constructs harboring BTLA-derived signaling domains.
[Molecular Therapy] |
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| Scientists demonstrated the power of using machine learning to analyze a single-cell, spatial, and highly multiplexed proteomic dataset from human pancreatic cancer and reveal underlying biological mechanisms that may contribute to clinical outcome.
[Cancer Immunology Research] |
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| Investigators developed a tough poly(vinyl alcohol) (PVA)-based hydrogel using a facile physical crosslinking method, comprising of PVA, tannic acid, and hydroxyapatite.
[International Journal Of Biological Macromolecules] |
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| The authors systematically evaluated the influence of age and brain region on survival, migration, and differentiation of transplant-derived cells.
[Scientific Reports] |
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| Gene therapy, a relatively nascent advanced approach, holds promise as a potential treatment for cancer, particularly glioblastoma multiforme. It possesses the potential to address the limitations of previous treatments and even newer advanced therapies like mAbs, owing to its distinct properties.
[Heliyon] |
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| Investigators examine current engineering approaches to control transcription in mammalian cells with an emphasis on systems that can be selectively activated in response to extracellular signals.
[SLAS Technology] |
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| A gene therapy technique developed by an Italian team has allowed an 11-year-old boy with a rare form of congenital deafness to hear for the first time.
[Nature Italy] |
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| Nearly four decades after its first conception, the first TIL therapy, an immunotherapy that harvests cancer-fighting immune cells from the patient’s own body, received accelerated approval from the FDA for advanced melanoma.
[STAT News] |
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| Lineage Cell Therapeutics, Inc. announced the clearance, by the FDA, of its Investigational New Drug amendment for OPC1, an investigational allogeneic oligodendrocyte progenitor cell transplant for the treatment of spinal cord injury.
[Lineage Cell Therapeutics, Inc.] |
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| April 4 – 5, 2024
Cincinnati, Ohio, United States |
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| | King’s College Hospital – London, England, United Kingdom |
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| | University of Barcelona – Barcelona, Catalonia, Spain |
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| | UC Davis – Davis, California, United States |
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| | BC Provincial Health Services Authority – Vancouver, British Columbia, Canada |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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