 | | Vol. 25.14 – 22 April, 2024 |
| |
|
|
| Researchers determined the combination effects of IL-21 in T cell therapy against HCC and investigate optimized strategies to utilize the effect of IL-21 signal in T cell therapy.
[Signal Transduction And Targeted Therapy] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists designed bispecific BC19 CAR T cells targeting BCMA/CD19 and evaluated antimyeloma activity in vitro and in vivo. Preclinical results indicated that BC19 CAR specifically recognized target antigens, and BC19 CAR T cells mediate selective killing of BCMA or CD19-positive cancer cells.
[Nature Communications] |
|
|
|
| Investigators engineered a Cellular Trojan Horse, named MetaCell, which used live neutrophils to stably internalize thermosensitive liposomal bimetallic Fe-Cu MOFs. MetaCell could instigate cuproptosis and ferroptosis, thereby enhancing treatment efficacy.
[Science Advances] |
|
|
|
| Investigators reported that homozygous deletion of ubiquitin-specific protease 8 (Usp8) in intestinal epithelial cells (IEC) led to architectural changes in the colonic epithelium and shortens mouse lifespan accompanied by increased IEC death and signs of lipid peroxidation.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
|
|
|
| The authors conducted a Phase I clinical trial to investigate the application of autologous lymphocyte infusion and anti-SLAMF7 monoclonal antibody, elotuzumab, after autologous stem cell transplantation in patients with newly diagnosed multiple myeloma previously treated with induction therapy.
[Journal For Immunotherapy Of Cancer] |
|
|
|
| The authors developed G47Δ-mIL2 using the flip-flop herpes simplex virus BAC system to deliver IL-2 locally within the tumor microenvironment (TME). They then tested its efficacy in orthotopic mouse GBM models and evaluated immune profiles in the treated tumors and spleens by flow cytometry and immunohistochemistry.
[Journal For Immunotherapy Of Cancer] |
|
|
|
| Researchers reported a novel subunit vaccine delivery platform constructed via in situ free radical polymerization of C7A (2-(Hexamethyleneimino) ethyl methacrylate) and acrylamide around the surface of individual protein antigens.
[Journal Of Controlled Release] |
|
|
|
| Scientists designed and characterized a novel bispecific antibody based on the IgG-(L)-ScFv format, which targeted L1CAM and CD3 simultaneously.
[Biomedicine & Pharmacotherapy] |
|
|
|
| 14 chordoma samples from patients attending Xuanwu Hospital Capital Medical University were subjected to single-cell RNA sequencing. Target molecules were identified on chordoma cells and cancer metastasis-related signaling pathways characterised.
[Journal Of Orthopaedic Translation] |
|
|
|
|
| Regulatory T cells are crucial for maintaining tolerance against self or nonself antigens. Of importance, Tregs also play an important role in dampening immune responses to AAV gene therapy, including tolerance induction to the transgene product.
[Human Gene Therapy] |
|
|
|
| The authors provide an overview of the new advances of CAR-T cells in the cure of multiple myeloma (MM), and look at the progress of the clinical use of CAR-T cells in MM to try to provide a reference for their clinical use when managing MM.
[Heliyon] |
|
|
|
|
| Congratulations to Dr. Lindsay Zhou on receiving the Perinatal Research Society Mont Liggins Award and the Cerebral Palsy Alliance Award from the Perinatal Society of Australia and New Zealand for his research on cord blood cell therapy.
[Monash University] |
|
|
|
| French-Canadian scientist Michel Sadelain was awarded an “Oscars of Science” prize in Los Angeles for his research into genetically modifying immune cells to fight cancer.
[Barron’s] |
|
|
|
|
| May 23 – 24, 2024
Berlin, Germany |
|
|
|
|
|
| | AstraZeneca – Cambridge, England, United Kingdom |
|
|
|
| | Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| | University of Oregon – Eugene, Oregon, United States |
|
|
|
| | Monash University – Melbourne, Victoria, Australia |
|
|
|
| | Virginia Commonwealth University – Richmond, Virginia, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
