Cell Therapy News Volume 6.19 | Apr 28 2005

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    Volume 6.19, April 28, 2005
         In this issue: Science | Policy | Business | NIH | CBER | Regulatory
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    Top Stories

    Story: Alzheimer’s Gene Therapy Hailed
    Article

    Story: Stem Cells from Brain Transformed to Produce Insulin at Stanford
    Article

    Science

    Donor Stem Cells Restore Sight
    Therapy which kickstarts repair could cut transplant need.
    Article

    Pulsating Ultrasound Enhances Gene Therapy for Tumors
    High-intensity focused ultrasound emitted in short pulses is a promising, non-invasive procedure for enhancing gene delivery to cancerous cells without destroying healthy tissue, according to a study in the May issue of the journal Radiology.
    Article

    Artificial Cornea Restores Vision
    A severe allergic reaction to a medication robbed Elma Phifer of her vision two decades ago when she was 39. The reaction scarred her corneas and reduced the ability of her eyes to soothe their damaged surfaces by remaining moist.
    Article

    Antibodies: Two Are Better Than One 
    Cancer patients may one day benefit from treatment with mixtures of customized antibodies. In a study published recently in the Proceedings of the National Academy of Sciences (USA), a team of Weizmann Institute scientists have demonstrated how the right combination might form a web that destroys the cancer cell’s communication network, ultimately demobilizing the cell. 
    Article

    Junior Scientist at Joslin Diabetes Center Earns Two Prestigious Career Development Grants to Study Stem Cells
    In addition to a highly competitive national grant, Amy Wagers, Ph.D., a young scientist at Joslin Diabetes Center, has received another prestigious career-development award. Together, these grants are providing seed money to advance her promising studies of how blood-forming “stem” cells develop, function and migrate — leading to more effective ways to treat diseases.
    Article

    ABSTRACT, REVIEWS, & SPECIAL REPORTS

    Cryopreservation Does Not Affect Proliferation and Multipotency of Murine Neural Precursor Cell
    Abstract

    Development of Humanized Antibodies as Cancer Therapeutics
    Abstract

    Serious Infections After Unrelated Donor Transplantation in 136 Children: Impact of Stem Cell Source
    Abstract

    Rapid and Complete Donor Chimerism After Unrelated Mismatched Cord Blood Transplantation in 5 Children with Beta-Thalassemia Major
    Abstract

    Policy

    California Institute for Regenerative Medicine Media Advisory: Site Search Subcommittee to Visit Four Finalist Sites for Permanent Headquarters
    Article

    US Panel Calls for National Stem Cell Standards
    Guidelines would set common standards for embryonic stem cell research
    Article

    Designer Babies Lawful to Help Sick Siblings, UK Law Lords Decide
    The creation of “designer babies” to treat sick siblings is lawful, the Law Lords have ruled, upholding an earlier court decision.
    Article

    Massachusetts Senate Approves Stem Cell Bill
    The state Senate overwhelmingly backed a stem cell research bill Tuesday and sent it to the House, where it could be debated as early as next week.
    Article

    Business

    BUSINESS NEWS

    Agencourt Bioscience to Be Acquired by Beckman Coulter; Wholly-Owned Subsidiary to Continue to Focus on Genomic Services and Reagent Solutions
    Article

    BrainStorm Cell Therapeutics, Appoints Renowned Neurologists Prof. Warren Olanow and Prof. Andre Lozano to Scientific Advisory Board; Completes Formation of Scientific Advisory Board
    Article

    Genzyme Corporation Reports Interim Results From Pivotal Study Of Myozyme(R)
    Genzyme Corp. announced today that it has completed a planned analysis of interim data from its pivotal clinical trial of Myozyme(R) (alglucosidase alfa), which is being studied for the treatment of Pompe disease.
    Article

    Insmed Begins Trial With SomatoKine in Type A Extreme Insulin Resistance
    Insmed has initiated a Phase II clinical trial examining the therapeutic benefit of treating Type A Extreme Insulin Resistance with SomatoKine, the company’s proprietary once daily IGF-I therapy.
    Article

    The Immune Response Presents Encouraging Results for Remune
    The Immune Response has presented results from a Phase II clinical trial with Remune, the company’s lead HIV immune-based therapy. 
    Article


    ImmunoGen, Inc. Announces Genentech Has Licensed Rights to Use ImmunoGen’s TAP Technology with Therapeutic Antibodies to a Second Target 
    Article

    U.S. BioDefense Confirms Provisional Patent Application for Matching Stem Cell and Other Biotechnology Transfer Opportunities
    Article

    Update of Neurologix Phase I Clinical Trial of Gene Therapy for Parkinson’s Disease Presented at AANS Annual Meeting
    Article

    OncoGenex Announces In-Licensing, Development Plans for Cancer Therapeutic
    OncoGenex Technologies has in-licensed the rights to inhibitors of heat shock protein 27 (Hsp27) from The University of British Columbia.
    Article

    Pall Debuts Five New Products for Increased Drug Manufacturing Efficiency at INTERPHEX 2005
    Pall Corporation introduces five innovative technologies aimed at increasing drug manufacturing efficiency through customization and disposability at INTERPHEX 2005 today. The new technologies deliver a combination of benefits that help drug manufacturers enhance throughput and scalability, eliminate time-consuming steps, shorten processing times and reduce labor.
    Article

    Neoprobe Receives Cellular Therapy Technology Assessment; Positive Technology Review and Clinical Recommendations Received
    The Battelle report indicates that the ACT cell processing technology would be commercially feasible and reproducible with CIRA Bio’s implementation of the recommended Battelle process and procedure development initiatives.
    Article

    Seattle Genetics Announces Antibody-Drug Conjugate Collaboration with MedImmune
    Article

    ViRexx Receives U.S. Patent For Immunotherapeutic Compound ProstaRex
    ViRexx Medical Corp. a company focused on immunotherapy treatments for cancer and chronic hepatitis B and C and embolotherapy treatments for tumors, today announced that it has been granted U.S. Patent 6,881,405 entitled, “Immunotherapeutic Composition and Method for the Treatment of Prostate Cancer”.
    Article

    Vitro Files New Patent for Stem Cell Therapy of Diabetes
    Vitro Diagnostics, Inc. announced the filing of a new patent application with the United States Patent and Trademark Office regarding a procedure for the generation of beta islets from stem cells.
    Article

    MARKET REPORTS

    Malachite Management has joined forces with established and reputable authors and publishers to bring you the following market reports outlining the very latest in Cell Therapy, Gene Therapy, and Immunotherapeutic approaches to Cancer. 

    “Cell Therapy – Technologies, Markets, and Companies” is over 400 pages of the basic technologies, clinical applications, market analysis, and company profiles related to the cell therapy industry worldwide.
    For more information, including order forms, please see:

    Cell Therapy Report Summary
    Cell Therapy Sample Chapter
    Cell Therapy Table of Contents Vol. 1  Vol. 2
    Cell Therapy Order Form

    “Gene Therapy – Technologies, Markets, and Companies” is over 500 pages of the basic technologies, clinical applications, market analysis, and company profiles related to the gene therapy industry worldwide.
    For more information, including order forms, please see:

    Gene Therapy Report Summary
    Gene Therapy Table of Contents Vol. 1 Vol. 2
    Gene Therapy Order Form

    The Immunotherapy Reports cover the most recent developments in the immunotherapeutic approaches to cancer.

    A Shift in Cancer Immunotherapy Strategies?
    Immunotherapy Strategies Executive Summary
    Immunotherapy Strategies Table of Contents

    Future Perspectives in Cancer Immunotherapy
    Future Perspectives Executive Summary
    Future Perspectives Table of Contents

    Immunotherapy Reports Order Form

    NIH


    NATIONAL INSTITUTES OF HEALTH

    NIH Awards Funding to Biotech Firm for Heart Disease, Stem Cell Research
    Arteriocyte, the first spin-out company from the Center for Stem Cell and Regenerative Medicine, has received the first installment of its combined Phase I/II “fast track” Small Business Technology Transfer Award grant from the National Heart, Lung, and Blood Institute (NHLBI), one of the components of the National Institutes of Health (NIH).
    Link

    Amendments to RFA-AI-05-002 “Units for HIV/AIDS Clinical Trials Networks”
    Link

    Cell Biological Studies of Parkinson’s Disease (RFA-NS-06-001)
    Link

    Development of Disease Biomarkers (PA-05-098)
    Link

    CBER

    All new CBER information can be reached from the What’s New page

    Processing Methods for Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps) Public Meeting” to be held in Rockville, Maryland, June 22-23
    Link

    Cellular, Tissue and Gene Therapies Advisory Committee- Meeting
    Link

    Exceptions and Alternative Procedures Approved Under 21 CFR 640.120 – Update
    Link

    Variances for Collection of Blood and Blood Products from Patients with Hemochromatosis – Update
    Link

    Biological Product Deviation Reports – Annual Summary for Fiscal Year 2004
    Link

    Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventive Vaccine Clinical Trials-Draft Guidance for Industry
    Link

    Regulatory

    NEWS & UPDATES

    AUSTRALIA & NEW ZEALAND

    MEDSAFE

    Regulatory Information: Consultants
    Link

    Therapeutic Goods Administration Homepage
    Link

    For Country-Specific & International Regulatory Resources, Including Regulatory Agencies Such As the FDA, EMEA, & More Please Visit Our Regulatory Page. 

    Meetings

    These meetings have been added to the calendar this week:

    SPECIAL Session at ISCT 2005: Development and Commercialization of Cell and Gene Therapy Products for Startup Companies
    May 5 at 2:00 – 3:30 in Ballroom C of the Vancouver Convention Center.
    Moderator:  Dr. Scott Burger, Ph.D.

    Speakers:
    Dr. Lorne Taichman, M.D., Ph.D. 
    Professor, Health Sciences Center, Stony Brook University, NY
    Consultant, Corporate Office of Science and Technology, Johnson & Johnson
    Approaching Big Pharma: A View from the Other Side of the Table

    Dr. Scott Burger, M.D.
    Principal, Advanced Cell & Gene Therapy, LLC, Chapel Hill, NC
    Land Mines on the Road to Cell Therapy

    Dr. Herbert Bresler, Ph.D.
    Chief Scientist, Health & Life sciences, Battelle, Columbus, OH
    The Closed Assembly Line: If Henry Ford Worked on Cell Therapy

    CHI’s Stem Cell Research: A Technology with the Promise to Contribute to All of Medicine. Cambridge, MA 
    August 29-31
    Link

    To View an Up-to-Date List of Cell Therapy-Related Meetings, Please Visit Our Meetings Page

    Journals

    To View a List of Cell Therapy-Related Journals, Please Visit Our Journals Page

    Careers

    JOB POSTINGS IN CELL THERAPY NEWS ARE FREE!
    For information on posting an opportunity email: info@connexoncreative.com

    Acting President
    San Diego, California (California Institute of Regenerative Medicine)

    Biologist (LMTB/DCGT/OCTGT)
    Bethsada, Maryland (CBER)

    Cell Therapy Specialist 
    Hackensack, New Jersey (Progenitor Cell Therapy, LLC)

    Cell Therapy Supervisor 
    New York, New York (New York Blood Center)

    Cell Therapy Technologist 
    New York, New York (New York Blood Center)

    Cellular Production Lead Technician
    Seattle, Washington (Fred Hutchinson Cancer Research Center)

    Clinical Laboratory Scientist
    Los Angeles, California (Cedars-Sinai Medical Center)

    Consultant– (AABB)

    Director of Cell Therapy
    New York, New York (New York Blood Center)

    Director of Research Programs 
    Toronto, Ontario (Ontario Genomics Institute)

    Faculty Positions in Stem Cell Research 
    Ottawa, Ontario (Ottawa Health Research Institute)

    Lab Technician 
    Sunrise, Florida (Bioheart Inc.)

    Laboratory Manager 
    Hackensack, New Jersey (Progenitor Cell Therapy, LLC)

    Marketing Manager 
    Denver, Colorado (Gambro BCT)

    Medical Laboratory Technologist (Stem Cell)
    Roswell Park Cancer Institute (Buffalo, New York) Post Doctoral or Engineer Positions 
    Toronto, Ontario (Centre for Computational Biology Hospital for Sick Children)

    Program Leader: Cell Biology (Professor/Associate Professor) NEW!
    Melbourne, Australia (Peter MacCallum Cancer Centre)

    Quality Assurance Associate
    Hackensack, New Jersey (Progenitor Cell Therapy, LLC)

    Quality Assurance Director 
    Hackensack, New Jersey (Progenitor Cell Therapy, LLC)

    Senior Hospital Scientist 
    Sydney, Australia (Australian Stem Cell Facility Sydney Children’s Hospital)

    Senior Scientist 
    Brussels, Belgium (Beta-Cell NV)

    Scientific/Technical Officer,Stem Cell Transplant Laboratory/Haematology 
    Sydney, Australia (SWAPS, Liverpool Hospital)

    Scientist, Bacteriology
    Potters Bar, Hertfordshire, England (National Institute for Biological Standards and Control)

    Stem Cell Specialist
    Philadelphia, PennsylvaniaA (Children’s Hospital of Philadelphia)

    Supervising Medical Laboratory Technologist (Quality Assurance)
    Buffalo, New York (Roswell Park Cancer Institute)

    Supervising Medical Laboratory Technologist (HLA, Stem Cell, Therapeutic Apheresis) 
    Buffalo, New York (Roswell Park Cancer Institute)

    Supervisor Cellular Activities 
    New York, New York (Memorial Sloan-Kettering Cancer Center)

    Technical Sales Representative 
    Vancouver, BritishC (StemCell Technologies)

    Therapy Scientist
    (Therapeutic Aphaeresis and Cell Therapy)
    Denver, Colorado (Gambro BCT)

    ISCT

    International Society for Cellular Therapy
    www.celltherapy.org

    Upcoming Meetings & Conferences:

    2005 Cell Therapy Audioconference Series

    May 3-4, 2005 Current Good Tissue Practice. Vancouver, BC
    Workshop Chairs: Janice Davis-Sproul, MAS, MT (ASCP) SBB (John Hopkins University) & John McMannis, PhD (MD Anderson Cancer Center)
    Email

    May 4-7th, 2005 11th Annual ISCT Meeting. Vancouver, BC
    Program Themes Include: Tissue Engineering, Mesenchymal Stem Cells, Immunotherapy, & Hematopoietic Stem Cells
    Email

    May 4-7th, 2005 Applications of Flow Cytometry in Marrow and Stem Cell Transplantation. Vancouver, BC
    Email

    Profiled Journal

     


     

    Join ISCT ($130) and receive the journal as a benefit of membership
    http://www.celltherapy.org/mem_app.htm

    Current Volume: Volume 7, Number 2 / May 2005

    Table of Contents:

    Selective allodepletion  p. 101
    M Cavazzana-Calvo, I André-Schmutz
     
    Improving immune reconstitution while preventing GvHD in allogeneic stem cell transplantation  p. 102
    I André-Schmutz, L Dal Cortivo, A Fischer, M Cavazzana-Calvo
     
    Selective depletion strategies in allogeneic stem cell transplantation  p. 109
    S Mielke, SR Solomon, AJ Barrett
     
    Add-back of allodepleted donor T cells to improve immune reconstitution after haplo-identical stem cell transplantation  p. 116
    PJ Amrolia, G Mucioli-Casadei, H Huls, HE Heslop, J Schindler, P Veys, E Vitetta, MK Brenner
     
    Selective elimination of alloreactivity from immunotherapeutic T cells by photodynamic cell purging and memory T-cell sorting  p. 126
    NT Le, BJ Chen, NJ Chao
     
    Elimination of alloreactive T cells using photodynamic therapy  p. 134
    R Sidi Boumédine, DC Roy
     
    Modulation of GvHD by suicide-gene transduced donor T lymphocytes: clinical applications in mismatched transplantation  p. 144
    F Ciceri, C Bonini, C Gallo-Stampino, C Bordignon
     
    Improving the ex vivo retroviral-mediated suicide-gene transfer process in T lymphocytes to preserve immune function  p. 150
    E Robinet, B Fehse, S Ebeling, D Sauce, C Ferrand, P Tiberghien
     
    Utilizing regulatory T cells to control alloreactivity  p. 158
    E Hauben, R Bacchetta, MG Roncarolo
     
    Therapeutic potential of CD4+ CD25+ regulatory T cells in allogeneic transplantation  p. 166
    JL Cohen, BL Salomon
     
    Methods for isolating circulating epithelial cells and criteria for their classification as carcinoma cells  p. 171
    T Fehm, EF Solomayer, S Meng, T Tucker, N Lane, J Wang, G Gebauer
     
    Pigpen is a cellular binding protein of therapeutic oligonucleotides  p. 186
    Z Zhang, HJ Schluesener
     
    Effect of prostaglandin E2, lipopolysaccharide, IFN-? and cytokines on the generation and function of fast-DC  p. 195
    L Alldawi, M Takahashi, M Narita, F Ayres, N Tsukada, Y Osman, T Furukawa, Y Aizawa

    Cytotherapy publishes original research, reviews, meeting reports, special focus issues and letters in the general field of cell therapy. The scope of the journal includes basic and applied research with hematopoietic and non-hematopoietic stem cells , immune cells, and antigen-presenting cells. Therapeutic topics within the scope of Cytotherapy include ex-vivo and in-vivo aspects of gene therapy, immunotherapy, stem cell transplantation and tissue regeneration. Cytotherapy particularly welcomes
    contributions from researchers, clinicians, technicians and individuals involved in regulatory aspects of cell therapy.
    www.cytotherapy.com


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