Top StoriesStory: Alzheimer’s Gene Therapy Hailed Article Story: Stem Cells from Brain Transformed to Produce Insulin at Stanford Article ScienceDonor Stem Cells Restore Sight Therapy which kickstarts repair could cut transplant need. Article Pulsating Ultrasound Enhances Gene Therapy for Tumors High-intensity focused ultrasound emitted in short pulses is a promising, non-invasive procedure for enhancing gene delivery to cancerous cells without destroying healthy tissue, according to a study in the May issue of the journal Radiology. Article Artificial Cornea Restores Vision A severe allergic reaction to a medication robbed Elma Phifer of her vision two decades ago when she was 39. The reaction scarred her corneas and reduced the ability of her eyes to soothe their damaged surfaces by remaining moist. Article Antibodies: Two Are Better Than One Cancer patients may one day benefit from treatment with mixtures of customized antibodies. In a study published recently in the Proceedings of the National Academy of Sciences (USA), a team of Weizmann Institute scientists have demonstrated how the right combination might form a web that destroys the cancer cell’s communication network, ultimately demobilizing the cell. Article Junior Scientist at Joslin Diabetes Center Earns Two Prestigious Career Development Grants to Study Stem Cells In addition to a highly competitive national grant, Amy Wagers, Ph.D., a young scientist at Joslin Diabetes Center, has received another prestigious career-development award. Together, these grants are providing seed money to advance her promising studies of how blood-forming “stem” cells develop, function and migrate — leading to more effective ways to treat diseases. Article ABSTRACT, REVIEWS, & SPECIAL REPORTS Cryopreservation Does Not Affect Proliferation and Multipotency of Murine Neural Precursor Cell Abstract Development of Humanized Antibodies as Cancer Therapeutics Abstract Serious Infections After Unrelated Donor Transplantation in 136 Children: Impact of Stem Cell Source Abstract Rapid and Complete Donor Chimerism After Unrelated Mismatched Cord Blood Transplantation in 5 Children with Beta-Thalassemia Major Abstract PolicyCalifornia Institute for Regenerative Medicine Media Advisory: Site Search Subcommittee to Visit Four Finalist Sites for Permanent Headquarters Article US Panel Calls for National Stem Cell Standards Guidelines would set common standards for embryonic stem cell research Article Designer Babies Lawful to Help Sick Siblings, UK Law Lords Decide The creation of “designer babies” to treat sick siblings is lawful, the Law Lords have ruled, upholding an earlier court decision. Article Massachusetts Senate Approves Stem Cell Bill The state Senate overwhelmingly backed a stem cell research bill Tuesday and sent it to the House, where it could be debated as early as next week. Article BusinessBUSINESS NEWS Agencourt Bioscience to Be Acquired by Beckman Coulter; Wholly-Owned Subsidiary to Continue to Focus on Genomic Services and Reagent Solutions Article BrainStorm Cell Therapeutics, Appoints Renowned Neurologists Prof. Warren Olanow and Prof. Andre Lozano to Scientific Advisory Board; Completes Formation of Scientific Advisory Board Article Genzyme Corporation Reports Interim Results From Pivotal Study Of Myozyme(R) Genzyme Corp. announced today that it has completed a planned analysis of interim data from its pivotal clinical trial of Myozyme(R) (alglucosidase alfa), which is being studied for the treatment of Pompe disease. Article Insmed Begins Trial With SomatoKine in Type A Extreme Insulin Resistance Insmed has initiated a Phase II clinical trial examining the therapeutic benefit of treating Type A Extreme Insulin Resistance with SomatoKine, the company’s proprietary once daily IGF-I therapy. Article The Immune Response Presents Encouraging Results for Remune The Immune Response has presented results from a Phase II clinical trial with Remune, the company’s lead HIV immune-based therapy. Article ImmunoGen, Inc. Announces Genentech Has Licensed Rights to Use ImmunoGen’s TAP Technology with Therapeutic Antibodies to a Second Target Article
U.S. BioDefense Confirms Provisional Patent Application for Matching Stem Cell and Other Biotechnology Transfer Opportunities Article Update of Neurologix Phase I Clinical Trial of Gene Therapy for Parkinson’s Disease Presented at AANS Annual Meeting Article OncoGenex Announces In-Licensing, Development Plans for Cancer Therapeutic OncoGenex Technologies has in-licensed the rights to inhibitors of heat shock protein 27 (Hsp27) from The University of British Columbia. Article Pall Debuts Five New Products for Increased Drug Manufacturing Efficiency at INTERPHEX 2005 Pall Corporation introduces five innovative technologies aimed at increasing drug manufacturing efficiency through customization and disposability at INTERPHEX 2005 today. The new technologies deliver a combination of benefits that help drug manufacturers enhance throughput and scalability, eliminate time-consuming steps, shorten processing times and reduce labor. Article Neoprobe Receives Cellular Therapy Technology Assessment; Positive Technology Review and Clinical Recommendations Received The Battelle report indicates that the ACT cell processing technology would be commercially feasible and reproducible with CIRA Bio’s implementation of the recommended Battelle process and procedure development initiatives. Article Seattle Genetics Announces Antibody-Drug Conjugate Collaboration with MedImmune Article ViRexx Receives U.S. Patent For Immunotherapeutic Compound ProstaRex ViRexx Medical Corp. a company focused on immunotherapy treatments for cancer and chronic hepatitis B and C and embolotherapy treatments for tumors, today announced that it has been granted U.S. Patent 6,881,405 entitled, “Immunotherapeutic Composition and Method for the Treatment of Prostate Cancer”. Article Vitro Files New Patent for Stem Cell Therapy of Diabetes Vitro Diagnostics, Inc. announced the filing of a new patent application with the United States Patent and Trademark Office regarding a procedure for the generation of beta islets from stem cells. Article MARKET REPORTS Malachite Management has joined forces with established and reputable authors and publishers to bring you the following market reports outlining the very latest in Cell Therapy, Gene Therapy, and Immunotherapeutic approaches to Cancer. “Cell Therapy – Technologies, Markets, and Companies” is over 400 pages of the basic technologies, clinical applications, market analysis, and company profiles related to the cell therapy industry worldwide. For more information, including order forms, please see: Cell Therapy Report Summary Cell Therapy Sample Chapter Cell Therapy Table of Contents Vol. 1 Vol. 2 Cell Therapy Order Form “Gene Therapy – Technologies, Markets, and Companies” is over 500 pages of the basic technologies, clinical applications, market analysis, and company profiles related to the gene therapy industry worldwide. For more information, including order forms, please see: Gene Therapy Report Summary Gene Therapy Table of Contents Vol. 1 Vol. 2 Gene Therapy Order Form The Immunotherapy Reports cover the most recent developments in the immunotherapeutic approaches to cancer. A Shift in Cancer Immunotherapy Strategies? Immunotherapy Strategies Executive Summary Immunotherapy Strategies Table of Contents Future Perspectives in Cancer Immunotherapy Future Perspectives Executive Summary Future Perspectives Table of Contents Immunotherapy Reports Order Form NIH NATIONAL INSTITUTES OF HEALTH
NIH Awards Funding to Biotech Firm for Heart Disease, Stem Cell Research Arteriocyte, the first spin-out company from the Center for Stem Cell and Regenerative Medicine, has received the first installment of its combined Phase I/II “fast track” Small Business Technology Transfer Award grant from the National Heart, Lung, and Blood Institute (NHLBI), one of the components of the National Institutes of Health (NIH). Link Amendments to RFA-AI-05-002 “Units for HIV/AIDS Clinical Trials Networks” Link Cell Biological Studies of Parkinson’s Disease (RFA-NS-06-001) Link Development of Disease Biomarkers (PA-05-098) Link CBERAll new CBER information can be reached from the What’s New page Processing Methods for Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps) Public Meeting” to be held in Rockville, Maryland, June 22-23 Link Cellular, Tissue and Gene Therapies Advisory Committee- Meeting Link Exceptions and Alternative Procedures Approved Under 21 CFR 640.120 – Update Link Variances for Collection of Blood and Blood Products from Patients with Hemochromatosis – Update Link Biological Product Deviation Reports – Annual Summary for Fiscal Year 2004 Link Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventive Vaccine Clinical Trials-Draft Guidance for Industry Link RegulatoryNEWS & UPDATES AUSTRALIA & NEW ZEALAND MEDSAFE Regulatory Information: Consultants Link Therapeutic Goods Administration Homepage Link For Country-Specific & International Regulatory Resources, Including Regulatory Agencies Such As the FDA, EMEA, & More Please Visit Our Regulatory Page. MeetingsThese meetings have been added to the calendar this week: SPECIAL Session at ISCT 2005: Development and Commercialization of Cell and Gene Therapy Products for Startup Companies May 5 at 2:00 – 3:30 in Ballroom C of the Vancouver Convention Center. Moderator: Dr. Scott Burger, Ph.D. Speakers: Dr. Lorne Taichman, M.D., Ph.D. Professor, Health Sciences Center, Stony Brook University, NY Consultant, Corporate Office of Science and Technology, Johnson & Johnson Approaching Big Pharma: A View from the Other Side of the Table Dr. Scott Burger, M.D. Principal, Advanced Cell & Gene Therapy, LLC, Chapel Hill, NC Land Mines on the Road to Cell Therapy Dr. Herbert Bresler, Ph.D. Chief Scientist, Health & Life sciences, Battelle, Columbus, OH The Closed Assembly Line: If Henry Ford Worked on Cell Therapy CHI’s Stem Cell Research: A Technology with the Promise to Contribute to All of Medicine. Cambridge, MA August 29-31 Link To View an Up-to-Date List of Cell Therapy-Related Meetings, Please Visit Our Meetings Page JournalsTo View a List of Cell Therapy-Related Journals, Please Visit Our Journals Page CareersJOB POSTINGS IN CELL THERAPY NEWS ARE FREE! For information on posting an opportunity email: info@connexoncreative.com
Acting President San Diego, California (California Institute of Regenerative Medicine) Biologist (LMTB/DCGT/OCTGT) Bethsada, Maryland (CBER) Cell Therapy Specialist Hackensack, New Jersey (Progenitor Cell Therapy, LLC) Cell Therapy Supervisor New York, New York (New York Blood Center) Cell Therapy Technologist New York, New York (New York Blood Center) Cellular Production Lead Technician Seattle, Washington (Fred Hutchinson Cancer Research Center) Clinical Laboratory Scientist Los Angeles, California (Cedars-Sinai Medical Center) Consultant– (AABB) Director of Cell Therapy New York, New York (New York Blood Center) Director of Research Programs Toronto, Ontario (Ontario Genomics Institute) Faculty Positions in Stem Cell Research Ottawa, Ontario (Ottawa Health Research Institute) Lab Technician Sunrise, Florida (Bioheart Inc.) Laboratory Manager Hackensack, New Jersey (Progenitor Cell Therapy, LLC) Marketing Manager Denver, Colorado (Gambro BCT) Medical Laboratory Technologist (Stem Cell) Roswell Park Cancer Institute (Buffalo, New York) Post Doctoral or Engineer Positions Toronto, Ontario (Centre for Computational Biology Hospital for Sick Children) Program Leader: Cell Biology (Professor/Associate Professor) NEW! Melbourne, Australia (Peter MacCallum Cancer Centre) Quality Assurance Associate Hackensack, New Jersey (Progenitor Cell Therapy, LLC) Quality Assurance Director Hackensack, New Jersey (Progenitor Cell Therapy, LLC) Senior Hospital Scientist Sydney, Australia (Australian Stem Cell Facility Sydney Children’s Hospital) Senior Scientist Brussels, Belgium (Beta-Cell NV) Scientific/Technical Officer,Stem Cell Transplant Laboratory/Haematology Sydney, Australia (SWAPS, Liverpool Hospital) Scientist, Bacteriology Potters Bar, Hertfordshire, England (National Institute for Biological Standards and Control) Stem Cell Specialist Philadelphia, PennsylvaniaA (Children’s Hospital of Philadelphia) Supervising Medical Laboratory Technologist (Quality Assurance) Buffalo, New York (Roswell Park Cancer Institute) Supervising Medical Laboratory Technologist (HLA, Stem Cell, Therapeutic Apheresis) Buffalo, New York (Roswell Park Cancer Institute) Supervisor Cellular Activities New York, New York (Memorial Sloan-Kettering Cancer Center) Technical Sales Representative Vancouver, BritishC (StemCell Technologies)
Therapy Scientist (Therapeutic Aphaeresis and Cell Therapy) Denver, Colorado (Gambro BCT) ISCTInternational Society for Cellular Therapy www.celltherapy.org Upcoming Meetings & Conferences: 2005 Cell Therapy Audioconference Series
May 3-4, 2005 Current Good Tissue Practice. Vancouver, BC Workshop Chairs: Janice Davis-Sproul, MAS, MT (ASCP) SBB (John Hopkins University) & John McMannis, PhD (MD Anderson Cancer Center) Email May 4-7th, 2005 11th Annual ISCT Meeting. Vancouver, BC Program Themes Include: Tissue Engineering, Mesenchymal Stem Cells, Immunotherapy, & Hematopoietic Stem Cells Email May 4-7th, 2005 Applications of Flow Cytometry in Marrow and Stem Cell Transplantation. Vancouver, BC Email Profiled Journal
Join ISCT ($130) and receive the journal as a benefit of membership http://www.celltherapy.org/mem_app.htm
Current Volume: Volume 7, Number 2 / May 2005 Table of Contents: Selective allodepletion p. 101 M Cavazzana-Calvo, I André-Schmutz Improving immune reconstitution while preventing GvHD in allogeneic stem cell transplantation p. 102 I André-Schmutz, L Dal Cortivo, A Fischer, M Cavazzana-Calvo Selective depletion strategies in allogeneic stem cell transplantation p. 109 S Mielke, SR Solomon, AJ Barrett Add-back of allodepleted donor T cells to improve immune reconstitution after haplo-identical stem cell transplantation p. 116 PJ Amrolia, G Mucioli-Casadei, H Huls, HE Heslop, J Schindler, P Veys, E Vitetta, MK Brenner Selective elimination of alloreactivity from immunotherapeutic T cells by photodynamic cell purging and memory T-cell sorting p. 126 NT Le, BJ Chen, NJ Chao Elimination of alloreactive T cells using photodynamic therapy p. 134 R Sidi Boumédine, DC Roy Modulation of GvHD by suicide-gene transduced donor T lymphocytes: clinical applications in mismatched transplantation p. 144 F Ciceri, C Bonini, C Gallo-Stampino, C Bordignon Improving the ex vivo retroviral-mediated suicide-gene transfer process in T lymphocytes to preserve immune function p. 150 E Robinet, B Fehse, S Ebeling, D Sauce, C Ferrand, P Tiberghien Utilizing regulatory T cells to control alloreactivity p. 158 E Hauben, R Bacchetta, MG Roncarolo Therapeutic potential of CD4+ CD25+ regulatory T cells in allogeneic transplantation p. 166 JL Cohen, BL Salomon Methods for isolating circulating epithelial cells and criteria for their classification as carcinoma cells p. 171 T Fehm, EF Solomayer, S Meng, T Tucker, N Lane, J Wang, G Gebauer Pigpen is a cellular binding protein of therapeutic oligonucleotides p. 186 Z Zhang, HJ Schluesener Effect of prostaglandin E2, lipopolysaccharide, IFN-? and cytokines on the generation and function of fast-DC p. 195 L Alldawi, M Takahashi, M Narita, F Ayres, N Tsukada, Y Osman, T Furukawa, Y Aizawa Cytotherapy publishes original research, reviews, meeting reports, special focus issues and letters in the general field of cell therapy. The scope of the journal includes basic and applied research with hematopoietic and non-hematopoietic stem cells , immune cells, and antigen-presenting cells. Therapeutic topics within the scope of Cytotherapy include ex-vivo and in-vivo aspects of gene therapy, immunotherapy, stem cell transplantation and tissue regeneration. Cytotherapy particularly welcomes contributions from researchers, clinicians, technicians and individuals involved in regulatory aspects of cell therapy. www.cytotherapy.com
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