The TriMark Molecular Diagnostics Conference 2008
October 6, 2008 | New York, New York
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The TriMark Stem Cell Conference 2008
October 20, 2008 | San Fransisco, California
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Recipe for Cell Reprogramming Adds Protein
A drug-like molecule called Wnt can be substituted for the cancer gene c-Myc, one of four genes added to adult cells to reprogram them to an embryonic-stem-cell-like state, according to Whitehead researchers.
Article
Putting MicroRNAs on the Stem Cell Map
Whitehead reasearchers have discovered how microRNAs fit into the map of embryonic stem cell circuitry. With this map, the scientists have moved one step closer to understanding how adult cells can be reprogrammed to an embryonic state and then to other types of cells, and to understanding the role of microRNAs in cancer and other diseases.
Article
SickKids Scientists Uncover the Key to Controlling How Stem Cells Develop
One of the biggest hurdles to overcome before the clinical use of embryonic stem cells is our current inability to effectively control the process of stem cell differentiation. This study provides a clear picture of how we might control the early steps of endoderm tissue differentiation.
Article
Non-Healing Bones Repaired in Clinical Trial Using Adult Stem Cells
The Royal Melbourne Hospital and Mesoblast Limited, jointly announced successful results from the long bone fracture repair clinical trial using Mesoblast’s proprietary adult stem cell technology.
Article
Argos Therapeutics’ Arcelis(TM) Personalized Immunotherapy Platform in HIV Achieves Primary Endpoint in Phase 1 Trial
Argos Therapeutics recently announced the presentation of positive immune response data from a Phase 1 clinical trial of AGS-004 in HIV-infected adults in combination with antiretroviral therapy.
Article
Aegera Therapeutics Initiates a Fifth Phase 1 and 2 Clinical Trial for AEG35156
Aegera Therapeutics Inc. is pleased to announce the dosing of the first patient in a fifth phase 1 and 2 clinical oncology study of AEG35156, a second generation antisense therapeutic targeting XIAP, a key member of the Inhibitor of Apoptosis protein family.
Article
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Directed Differentiation of Hippocampal Stem/Progenitor Cells in the Adult Brain
The researchers found that retrovirus-mediated overexpression of a single gene, the bHLH transcription factor Ascl1, redirected the fate of the proliferating adult hippocampal stem/progenitor progeny and lead to the exclusive generation of cells of the oligodendrocytic lineage at the expense of newborn neurons, demonstrating that AHPs in the adult mouse brain are not irrevocably specified in vivo.
Article
Potential of Stem Cell-Based Therapies for Liver Regeneration
The researchers constructed implantable bioartificial liver assist system with the stem cell derived hepatocytes as the seed cells by means of biofabrication, and explored effects of biochemical and mechanic characters on hepatic modality, structure and function.
Article
Human Embryonic Stem Cell-Derived Dopaminergic Neurons Reverse Functional Deficit in Parkinsonian Rats
In this paper, the researchers show that hESC-derived dopaminergic neurons survived a long-term transplantation to the neurotoxin 6-hydroxydopamine (6-OHDA) lesioned rat striatum, and in combination with those cells newly differentiated from their progenitors, contributed to locomotive function recovery at 5 months.
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