The TriMark Molecular Diagnostics Conference 2008
October 6, 2008 | New York, New York
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The TriMark Stem Cell Conference 2008
October 20, 2008 | San Fransisco, California
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Yale Researchers Discover Tiny Cellular Antennae Trigger Neural Stem Cells
Yale University scientists recently reported evidence suggesting that the tiny cilia found on brain cells of mammals, thought to be vestiges of a primeval past, actually play a critical role in relaying molecular signals that spur creation of neurons in an area of the brain involved in mood, learning and memory.
Article
Lab-Grown Tendons Gradually Fade to Bone
Tissue engineering can produce tendons, cartilage, and even bladders. But only now have researchers managed to make different tissues blend into one another, as they do naturally in the body.
Article
Mesoblast’s Stem Cells Regrow Knee Cartilage in Severe Post-Menopausal Osteoarthritis
Mesoblast Limited, recently announced successful preclinical trial results which showed that its proprietary adult stem cells regenerated and regrew damaged knee cartilage in post-menopausal osteoarthritis.
Article
Alnylam and Collaborators Publish New Pre-Clinical Research on RNAi-Mediated Silencing of PCSK9, a Genetically Validated Regulator of LDL Metabolism
The published, peer-reviewed data demonstrate for the first time that a chemically synthesized small interfering RNA (or siRNA, the molecules that mediate RNAi) targeting the gene proprotein convertase subtilisin/kexin type 9 (PCSK9) achieves acute and durable lowering of total cholesterol levels in both mice and rats, and LDL cholesterol levels in non-human primates.
Article
Pluristem’s PLX-MS Shows Potential Benefit in the Prevention of Multiple Sclerosis
Pluristem Therapeutics Inc. recently announced that the Company’s PLacental eXpanded cells have demonstrated in vivo efficacy in the prevention of Multiple Sclerosis. PLX cells are Pluristem’s placental-derived mesenchymal stromal cells that have been expanded in the Company’s proprietary PluriX(TM) 3-D bioreactor.
Article
ImmuneRegen(R) BioSciences Confirms Homspera(R) Advances Wound Healing in Topical Application
ImmuneRegen(R) BioSciences, Inc., recently announced that in a controlled study performed on Yorkshire pigs, its wound-healing drug candidate, Homspera(R), has accelerated the healing process of deep, dermal excisions.
Article
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Direct Intrabone Transplant of Unrelated Cord-Blood Cells in Acute Leukaemia: a Phase I/II Study
Cord-blood transplants are associated with delayed or failed engraftment in about 20% of adult patients. The aim of this phase I/II study was to establish the safety and efficacy of a new administration route (intrabone) for cord-blood cells, measured by the donor-derived neutrophil and platelet engraftment.
Article
Regulation of Self-Renewal and Pluripotency by Sox2 in Human Embryonic Stem Cells
To determine the role of Sox2 in maintaining hES cell pluripotency and self-renewal, the researchers used RNA interference to specifically knock down Sox2 gene expression. Reduction of Sox2 expression in hES cells results in loss of the undifferentiated stem cell state, as indicated by a change in cell morphology, altered stem cell marker expression, and increased expression of trophectoderm markers.
Article
Improved Efficiency and Pace of Generating Induced Pluripotent Stem Cells from Human Adult and Fetal Fibroblasts
The efficiency of generating human induced pluripotent stem cells is low, especially for postnatal human fibroblasts. The researcheres report here that adding SV40 large T antigen to either set of the four reprogramming genes previously used enhanced the efficiency by 23–70-fold from both human adult and fetal fibroblasts.
Article
Putative Dental Pulp Derived Stem/Stromal Cells Promote Proliferation and Differentiation of Endogenous Neural Cells in the Hippocampus of Mice
Until now, interest in dental pulp stem/stromal cell research has centered on mineralization and tooth repair. Beginning a new paradigm in dental pulp stem/stromal cell research, researchers grafted undifferentiated, untreated dental pulp stem/stromal cells into the hippocampus of immune-suppressed mice.
Article
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