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Adult Brain Neurons can Remodel Connections
Overturning a century of prevailing thought, scientists are finding that neurons in the adult brain can remodel their connections.
Article
Mammals can be Stimulated to Regrow Damaged Inner Retina Nerve Cells
The researchers pointed out the remarkable ability of cold-blooded vertebrates like fish to regenerate their retinas after damage. Birds, which are warm-blooded, have some limited ability to regenerate retinal nerve cells after exposure to nerve toxins.
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Not as Easy as it May Seem
Using adult stem cells to replace neurons lost because of brain damage and disease could be more difficult than previously thought because newly formed brain cells receive messages before they are capable of sending them.
Article
The Light Syringe
Scientists at the University of St Andrews have developed an innovative method allowing insoluble compounds such as genes and drugs to be injected into individual cells with the assistance of light.
Article
Seven Investigator-Initiated Clinical Studies Announced
Cytori announced today it has been informed that seven new investigator-initiated clinical studies in Japan using adipose-derived regenerative cells have been approved by local ethical committees.
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Ceregene Announces Clinical Data from Phase 2 Clinical Trial of CERE-120 for Parkinson’s Disease
Ceregene, Inc. recently reported clinical data from a double-blind, controlled Phase 2 trial of CERE-120 in 58 patients with advanced Parkinson’s disease.
Article
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
IGF-1–Overexpressing Mesenchymal Stem Cells Accelerate Bone Marrow Stem Cell Mobilization via Paracrine Activation of SDF-1{alpha}/CXCR4 Signaling to Promote Myocardial Repair
The researchers hypothesized that mesenchymal stem cells overexpressing insulin-like growth factor-1 showed improved survival and engraftment in the infarcted heart and promoted stem cell recruitment through paracrine release of stromal cell–derived factor (SDF)-1{alpha}.
Article
Generation of Cardiomyocytes from New Human Embryonic Stem Cell Lines Derived from Poor-quality Blastocysts
This study shows that hES cell lines can be obtained from poor-quality blastocysts with the same efficiency as that obtained from good- or intermediate-quality blastocysts.
Article
Epithelial Stem/Progenitor Cells in Lung Postnatal Growth, Maintenance, and Repair
To address how repair of different epithelial cell types in the lung are mediated, the researchers have developed genetic lineage-labeling techniques in the mouse.
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The Conditioned Media of Adipose Stromal Cells Protect Against Hypoxia-Ischemia-Induced Brain Damage in Neonatal Rats
This paper directly tested the ability of media collected from cultured adipose-derived stem cells to protect neurons in a rat model of brain hypoxic-ischemic injury.
Article
The Wnt Modulator sFRP2 Enhances Mesenchymal Stem Cell Engraftment, Granulation Tissue Formation and Myocardial Repair
Cell-based therapies, using multipotent mesenchymal stem cells for organ regeneration were studied comparing mesenchymal stem cells isolated from MRL/MpJ mice, known to demonstrate enhanced regenerative capacity, to those from C57BL/6 mice.
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