Cord Blood News Volume 10.07 | Feb 22 2018

TOP STORY

Mouse and Human HSPC Immobilization in Liquid Culture by CD43 or CD44-Antibody Coating

Scientists tested antibody coating for reducing hematopoietic stem and progenitor cell (HSPC) motility in vitro. Anti-CD43 and -CD44 antibody coating reduced cell motility of mouse and human HSPCs in a concentration dependent manner. Human umbilical cord hematopoietic CD34⁺ cell survival, proliferation and differentiation was not affected by either coating. [Blood] Abstract

(Ranked by impact factor of the journal)

Nano-Loaded Human Umbilical Cord Mesenchymal Stem Cells as Targeted Carriers of Doxorubicin for Breast Cancer Therapy

Investigators constructed human umbilical cord derived mesenchymal stem cells carrying transferrin-inspired-nanoparticles that contain doxorubicin to achieve enhanced anti-tumor efficacy and made an evaluation. [Artif Cells Nanomed Biotechnol] Abstract

Cord Blood Buffy Coat DNA Methylation Is Comparable to Whole Cord Blood Methylation

The authors evaluated differences in cell composition and DNA methylation between cord blood buffy coat and whole cord blood samples. Cord blood DNA methylation was measured with the Infinium EPIC BeadChip in eight individuals, each contributing buffy coat and whole blood samples. [Epigenetics] Abstract

Effects of Prophylactic Foscarnet on HHV-6 Reactivation and HHV-6 Encephalitis in Cord Blood Transplant Recipients: A Prospective Multicenter Trial with a Historical Control Group

Cord blood transplantation (CBT) is a distinct risk factor for human herpesvirus-6 (HHV-6) reactivation and HHV-6 encephalitis. In a prospective multicenter trial, scientists investigated the effects of prophylactic foscarnet on the occurrence of HHV-6 reactivation, HHV-6 encephalitis, and acute graft-versus-host disease in CBT recipients. [Biol Blood Marrow Transplant] Abstract

Effects of Umbilical Cord Blood Cells, and Subtypes, to Reduce Neuroinflammation following Perinatal Hypoxic-Ischemic Brain Injury

Investigators examined whether human umbilical cord blood (UCB), or specific UCB cell types, could reduce peripheral and cerebral inflammation, and promote brain repair, when given early after perinatal hypoxic-ischemic brain injury. [J Neuroinflammation] Full Article

Porcine Wharton’s Jelly Cells Distribute throughout the Body after Intraperitoneal Injection

Scientists showed that porcine Wharton’s jelly cells distribute widely to the organs in immunocompetent allogeneic hosts after IP administration. They may distribute through the lymphatics initially, and a prominent site of incorporation is the mucosa of the gastrointestinal tract. In that location they could function in the niche of endogenous stem cells and provide secretory products to cells in the tissue damaged by intestinal disease. [Stem Cell Res Ther] Full Article

Treating Childhood Traumatic Brain Injury with Autologous Stem Cell Therapy

Scientists discuss the use of umbilical cord blood cells and bone marrow stromal cells for acute and chronic treatment of experimental neonatal traumatic brain injury. [Expert Opin Biol Ther] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Amgen Announces FDA Advisory Committee Meeting to Review Potential New Use Of BLINCYTO^® (Blinatumomab)

Amgen announced that the Oncologic Drugs Advisory Committee of the FDA will review data supporting the BLINCYTO^® supplemental Biologics License Application for the treatment of patients with minimal residual disease-positive B-cell precursor acute lymphoblastic leukemia. [Amgen] Press Release

Cancer Research UK to Invest £45 Million in Clinical Trials

Cancer Research UK announced that £45 million will be invested into its network of clinical trials units across the UK, one of the charity’s largest investments in clinical research to date. [Cancer Research UK] Press Release

Pitt, UPMC Announce $200 Million Immunotherapy Investment, Creation of Innovation Facility

The University of Pittsburgh (Pitt) and University of Pittsburgh Medical Center (UPMC) announced plans to establish the new UPMC Immune Transplant and Therapy Center, with much of its activity planned within an eight-story innovation hub—all part of a concerted effort to harness the power of the human immune system to treat and cure a wide range of diseases. [The University of Pittsburgh Medical Center] Press Release

Half of Canada’s Government Scientists Still Feel Muzzled

More than half of government scientists in Canada—53%—do not feel they can speak freely to the media about their work, even after Prime Minister Justin Trudeau’s government eased restrictions on what they can say publicly, according to a survey released by a union that represents more than 16,000 federal scientists. [ScienceInsider] Editorial

Indonesian Scientists Hamstrung by Year-Long Funding Delay

Indonesian scientists expecting to receive hundreds of thousands of dollars for research are stuck in limbo because the country’s first dedicated science-funding agency is struggling to raise enough money. [Nature News] Editorial

Italian Election Leaves Science Out in the Cold

As campaigning ahead of Italy’s national election enters its final weeks, researchers in the country fear that budget cuts and declining interest in science will only continue — whatever the outcome of the vote. [Nature News] Editorial

NEW Development Meeting – From Stem Cells to Human Development
September 23-26, 2018
Surrey, United Kingdom

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow & Scientist – Acute Myeloid Leukemia (Institute of Hematology)

Postdoctoral Fellowship – Functional Genomics of Human Hematopoiesis (Boston Children’s Hospital)

Postdoctoral Fellowship – Leukemia (Lund University)

Postdoctoral Fellow Positions – Hematopoietic Stem Cell Biology (Nationwide Childrens Hospital and Ohio State University)

Postdoctoral Research Associate – Hematopoiesis (University of North Dakota)

Postdoctoral Scholar – Leukemia (University of Southern California)

Postdoctoral Research Fellow – Fanconi Anemia (Cincinnati Children’s Hospital Medical Center)

Scientific Manager – Cell Engineering Lab (Genentech, Inc.)

Research Fellow – Pediatric Cancer and Zebrafish Models (Massachusetts General Hospital)

Postdoctoral Scientists and Research Technologists – Hematopoiesis and Leukemogenesis (City of Hope)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Cord Blood News? Click here to submit!

Comments or suggestions? Submit your feedback here.