Cord Blood News Volume 10.18 | May 10 2018

TOP STORY

CXCL12/CXCR4 Signaling Enhances Human PSC-Derived Hematopoietic Progenitor Function and Overcomes Early In Vivo Transplantation Failure

The authors revealed that networks involving CXCR4 should be targeted to generate putative hematopoietic stem cells with in vivo function from human pluripotent stem cells. [Stem Cell Reports] Full Article | Graphical Abstract

(Ranked by impact factor of the journal)

Leukemic Alterations of IKZF1 Prime Stemness and Malignancy Programs in Human Lymphocytes

Scientists uncovered upregulated stem cell program in leukemic lymphoblasts of patients with IKZF1 alterations by analyzing the archived gene-expression profiling datasets. They then used a frequent IKZF1 deletion, IK6, as a model via transduction into human primitive hematopoietic cells, followed by xenotransplantation in mice. [Cell Death Dis] Full Article

Identifying MicroRNA Determinants of Human Myelopoiesis

Investigators characterized the miRNA profile of human CD34⁺CD38⁺ myeloid progenitor cells, and mature monocytes and granulocytes isolated from cord blood using TaqMan Low Density Arrays. [Sci Rep] Full Article

Osmotic Modulation of Chromatin Impacts on Efficiency and Kinetics of Cell Fate Modulation

Hyposmotic modulation constitutes an alternative route to manipulate cell fate decisions. This technology was tested in model protocols of induced pluripotency and transdifferentiation in cells growing in suspension and adherent to substrates, CD34⁺ umbilical-cord-blood, fibroblasts and B-cells. [Sci Rep] Full Article

Foxp3 Expression in Induced T Regulatory Cells Derived from Human Umbilical Cord Blood vs. Adult Peripheral Blood

Investigators examined Foxp3 expression and regulation comparing human-induced Treg (iTreg) differentiated from umbilical cord blood (UCB) vs. adult blood (AB) naive CD4⁺ T-cells. Foxp3 expression was higher in UCB vs. AB-derived iTreg, and was sustained during 21-day expansion in vitro. [Bone Marrow Transplant] Abstract

Angiogenic Potential of Spheroids from Umbilical Cord and Adipose-Derived Multipotent Mesenchymal Stromal Cells within Fibrin Gel

Analysis of tubule growth rate, length, and branching showed that the differentiated ADSCs had higher angiogenic potential than the differentiated hUC MMSCs. [Biomed Mater] Abstract

Mesenchymal Stem Cells Drive Paclitaxel Resistance in ErbB2/ErbB3-Coexpressing Breast Cancer Cells via Paracrine of Neuregulin 1

Scientists explored the possible role of MSCs in regulating the paclitaxel-sensitivity of ErbB2/ErbB3-coexpressing breast cancer cells. They showed that human umbilical cord-derived MSCs express significantly higher level of neuregulin-1 as compared with ErbB2/ErbB3-coexpressing breast cancer cells themselves. [Biochem Biophys Res Commun] Abstract

Homing Genes Expression in Fucosyltransferase VI-Treated Umbilical Cord Blood CD133⁺ Cells which Expanded on Protein-Coated Nanoscaffolds

Fibronectin-collagen-selectin-protein-coated poly l-lactic acid scaffolds provided optimal conditions for viability of fucosyltransferase-VI-treated CD133⁺ cells, and clonogenicity with the goal of improving homing following umbilical cord blood-derived hematopoietic stem cells transplantation. [Mol Biotechnol] Abstract

Hematopoietic Stem Cell Transplantation for Adult Sickle Cell Disease in the Era of Universal Donor Availability

Ongoing investigations using matched umbilical cord units, unrelated matched donor, and related haploidentical donors, promises to make hematopoietic cell transplantation (HCT) a viable option for nearly all eligible patients with sickle cell disease (SCD). The authors focus on the recent data for HCT for patients with adult SCD with particular emphasis on donor sources and availability as illustrated by a case presentation exhibiting real world issues. [Bone Marrow Transplant] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Creative Medical Technology Holdings Files Patent on Anti-Aging Technology Using AmnioStem Stem Cells

Creative Medical Technology Holdings announced filing of patent application number 62663912 covering the use of its AmnioStem^™ stem cells as a means of reducing/reversing natural aging. [Creative Medical Technology (PR Newswire Association, LLC.)] Press Release

Daiichi Sankyo Announces Single Agent Quizartinib Significantly Prolongs Overall Survival Compared with Chemotherapy in Patients with Relapsed/Refractory AML with FLT3-ITD Mutations (QuANTUM-R Study)

Daiichi Sankyo Company, Limited announced that the pivotal QuANTUM-R Phase III study of single agent quizartinib met its primary endpoint of significantly prolonging overall survival compared to salvage chemotherapy in patients with relapsed/refractory acute myeloid leukemia (AML) with FLT3-ITD mutations after first-line treatment with or without hematopoietic stem cell transplantation. [Daiichi Sankyo Company, Limited] Press Release

Kalytera Announces Issuance of Second Patent Covering the Use of CBD in Graft versus Host Disease

Kalytera Therapeutics, Inc. announced that the U.S. Patent and Trademark Office issued U.S. Patent No. 9,956,182 with claims covering the use of cannabidiol (CBD) for the prevention and treatment of acute and chronic forms of graft versus host disease. [Kalytera Therapeutics, Inc.] Press Release

FDA Seeks Permanent Injunctions against Two Stem Cell Clinics

The FDA, in two complaints filed in federal court, is seeking permanent injunctions to stop two stem cell clinics from marketing stem cell products without FDA approval and for significant deviations from current good manufacturing practice requirements. [U.S. Food and Drug Administration] Press Release

Australian Budget Delivers for Science Facilities and Medical Research

The government will push to invest almost Aus$1.9 billion (US$1.4 billion) over the next 12 years in shared research infrastructure — such as microscopes, supercomputers, a marine observing system and telescopes used in myriad disciplines, from nanotechnology to oceanography. Medical research will receive an increase of $1.3 billion, to be spent on various programs and initiatives over 10 years that improve health and boost the medical industry, including $500 million for a genomics and precision-medicine initiative. [Nature News] Editorial

Animal Tests Surge under New U.S. Chemical Safety Law

The cause of the increase isn’t clear. But the new law imposes stricter requirements on a broader array of chemicals than its predecessor, including both new products and ones already on the market, and experts say Environmental Protection Agency staff may be trying to comply by gathering more test data from companies. [ScienceInsider] Editorial

NEW American Association of Blood Banks (AABB) 2018
October 13-16, 2018
Boston, Massachusetts, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Research Scholar – Hematologic Malignancies (Washington University School of Medicine)

Postdoctoral Position – Leukemia (Oslo Universitetssykehus HF)

Postdoctoral Fellow – B-Cell Lymphoma (University of Texas Health Science Center)

Postdoctoral Fellow – Hematopoiesis and Leukemia (University of Pennsylvania)

Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center)

Postdoctoral Fellow – Molecular and Translational Cancer Biology (Thomas Jefferson University)

Postdoctoral Position – Hematology (Yale Cancer Center)

Bioinformatics Research Scientist – Brain Tumors and Leukemia (St. Jude Children’s Research Hospital)

Pathology Faculty Tenure Track – Leukemia and Hematopoiesis (University of Virginia)

Postdoctoral Scholar – Hematology (Huntsman Cancer Institute)

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